Encequidar-mesylate-hydrochloride-HM30181-mesylate-hydrochloride-DataSheet-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEEncequidarmesylatehydrochlorideCat.No.:HY-13646CCASNo.:2097125-58-9Synonyms:HM30181mesylatehydrochloride;HM30181Amesylatehydrochloride分⼦式:C₃₉H₄₂N₆O₁₁S分⼦量:802.85作⽤靶点:P-glycoprotein作⽤通路:MembraneTransporter/IonChannel储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Encequidar(HM30181)mesylatehydrochloride⼀种有效的、选择性的P-糖蛋⽩(MDR1)抑制剂。Encequidarmesylatehydrochloride提⾼紫杉醇(HY-B0015)在⼩⿏肿瘤模型中的抗肿瘤功效。户使⽤本产品发表的科研⽂献•NatCommun.2021Jan12;12(1):312.•CritRevAnalChem.2021Mar10;1-15.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].BauerF,etal.InteractionofHM30181withP-glycoproteinatthemurineblood-brainbarrierassessedwithpositronemissiontomography.EurJPharmacol.2012Dec5;696(1-3):18-27.[2].KimTE,etal.EffectsofHM30181,aP-glycoproteininhibitor,onthepharmacokineticsandpharmacodynamicsofloperamideinhealthyvolunteers.BrJClinPharmacol.2014Sep;78(3):556-64.[3].McCawZR,etal.AssessingtheClinicalUtilityofOralPaclitaxelPlusEncequidarVersusIntravenousPaclitaxelinPatientsWithMetastaticBreastCancer.JClinOncol.2023Feb20;41(6):1323.McePdfHeight1/1MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemECaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:02