几家代表性医院检验科现开展检验项目课件

几家代表性医院

检验科现开展检验项目几家代表性医院检验科现开展检验项目课件第1页JohnsHopkinsMedicalLaboratories项目介绍华西医院检验科项目介绍协和医院检验科项目介绍中山达安基因项目介绍肿瘤个体化用药惯用项目介绍我思索几家代表性医院检验科现开展检验项目课件第2页JohnsHopkinsMedicalLaboratories600NorthWolfeStreetMeyerB-130Baltimore,MD21287-7070Phone410-955-2405Fax410-614-0455几家代表性医院检验科现开展检验项目课件第3页JHMLServices

BloodDisorders&SpecialCoagulation临检和凝血ClinicalChemistry生化Cytokine细胞因子HIVSpecialtyServicesHIV筛查Immunology免疫MedicalMicrobiology医学微生物MolecularPathology&Cytogenetics分子病理和细胞基因NeoplasticHematopathology&FlowCytometry血液病理和流式细胞仪TransfusionMedicine血库几家代表性医院检验科现开展检验项目课件第4页CardiovascularPanel心血管项目组合

Testabnormalitiesinthispanelcorrelatewithanincreasedriskofcardiovasculardisorders.

FactorVIIActivity

FibrinogenActivity

Homocysteine(specialcollection)

Lipoprotein(a)

PlasminogenActivatorInhibitor-1(PAI-1)

ProthrombinFragment1.2

TissuePlasminogenActivatorAntigen几家代表性医院检验科现开展检验项目课件第5页CirculatingAnticoagulantandLupusAnticoagulant循环抗凝和狼疮抗凝

Abasicscreeningpanelforfactordeficienciesandthedetectionofinhibitors.

APTT

MixingStudies(APTT)

MixingStudies(PT)

PT(ProthrombinTime)

PlateletNeutralization

d-RVVT,withconfirm

Anti-cardiolipenAntibody,IgG,IgM,IgA

Anti-B2GP1antibodies,IgG,IgM,IgA几家代表性医院检验科现开展检验项目课件第6页AbnormalPTand/orAPTTEvaluation普通凝血检验

Thispanelisusedtoevaluatethecauseofanabnormalprotimeoractivatedpartialthromboplastintime.

APTT

APTTMixingStudies

Hepzyme(Testforheparincontamination)

PT(ProthrombinTime)

PT(ProthrombinTime)MixingStudies

PlateletNeutralization几家代表性医院检验科现开展检验项目课件第7页DDAVPChallenge血管加压素耐受性ThepanelisusedtoevaluatetheresponseofmildhemophiliaandvonWillebranddiseasepatientstoDDAVP.

FactorVIIIActivity

RistocetinCoFactorassay

WFAntigen

HEME-8(pre-post)几家代表性医院检验科现开展检验项目课件第8页DICScreenDIC筛查

TheDICscreenisusefulinthediagnosisandfollow-upofdisseminatedintravascularcoagulation.

APTT

D-dimer(Quantitative)

Fibrinogen

ProthrombinTime几家代表性医院检验科现开展检验项目课件第9页ExtrinsicPathwayPanel外凝血通路组合Panelusedtoevaluateandidentifythecauseofanabnormalprothrombintime.

FactorVIIActivity

FactorXActivity

FactorVActivity

FactorIIActivity几家代表性医院检验科现开展检验项目课件第10页IntrinsicPathwayPanel内凝血通路组合Panelcanbeusedtoevaluateandidentifythecauseofanabnormalactivatedpartialthromboplastintime.

FactorXIIActivity

FactorXIActivity

FactorIXActivity

FactorVIIIActivity几家代表性医院检验科现开展检验项目课件第11页FibrinolysisPanel纤维蛋白溶解组合

Thefibrinolysispanelmaybeusedtomonitorordiagnoseacquiredorcongenitalabnormalitiesofthefibrinolyticsystem.

alpha-2-Antiplasmin

D-dimerQuantitative

FibrinogenDegradationProducts

PlasminogenActivatorInhibitor-1(PAI-1)

PlasminogenActivity

TissuePlasminogenActivatorAntigen几家代表性医院检验科现开展检验项目课件第12页LupusAnticoagulant(AntiphospholipidScreen)狼疮抗凝(抗磷脂筛查

Abasicscreeningpanelforthedetectionoflupus-likeinhibitors.TheprofilemayalsobeusedforpatientswithanunexplainedprolongedprothrombintimeorAPTT.

AnticardiolipinAntibody(ELISA)

APTTandMixingStudies

D-RVVT(DiluteRussellViperVenom)andMixingStudies

PT(ProthrombinTime)andMixingStudies

PlateletNeutralizationTestifevidenceforaninhibitor几家代表性医院检验科现开展检验项目课件第13页PlateletFunctionPanel血小板功效组合

Panelusedtoidentifyplateletfunctionproblems.

PFA-100

BleedingTime

ClotRetraction

PlateletAggregation

PlateletSecretion(ATPrelease)

Flowcytometrystudiesifindicated

ProthrombinConsumptionTest几家代表性医院检验科现开展检验项目课件第14页ThromboticRiskPanel血栓风险组合

Thethromboticriskpanelisacomprehensivegroupoftestsforevaluatingpatientswithhypercoagulablestates.

ActivatedProteinCResistanceandFactorVLeiden

AntithrombinIIIActivity

DiluteRussell'sViperVenom(D-RVVT)

FibrinogenActivity,FibrinogenAntigen

Homocysteine(specialcollection)

Lipoprotein(a)

LupusAnticoagulantScreen

PlasminogenActivatorInhibitor1(PAI-1)

PlasminogenActivity

CActivity

ProteinCAntigen

ProteinSActivityProteinSAntigenTotal

ThrombinTime

TissuePlasminogenActivatorAntigen

ProthrombinGeneMutation几家代表性医院检验科现开展检验项目课件第15页ThromboticRiskScreen血栓风险筛检Agroupofbasictestsusedtoscreenpatientsforonlythemostcommoncausesofthrombosis.

ActivatedProteinCResistance

AntithrombinIIIActivity

D-RVVT

Homocysteine(specialcollection)

ProteinCActivity

ProteinSActivity几家代表性医院检验科现开展检验项目课件第16页vonWillebrandPanel血管性血友病因子

ThispanelisfortheevaluationofsuspectedvonWillebranddisease.

APTT

FactorVIIIActivity

RistocetinCofactor

vWFAntigen

vWFMultimersasneeded几家代表性医院检验科现开展检验项目课件第17页MarkersofHyper-Coagulation高凝状态标志物Prothrombinfragment1,2

Plasmap-Selectin

Thromboxane

Beta-Thromboglobulin

PF4MiscellaneousBleedingDisorders各种出血紊乱FactorXIIIActivity几家代表性医院检验科现开展检验项目课件第18页ProteinTests特种蛋白

CryoglobulinScreenwithreflextoimmunofixationelectrophoresisforpositivesCSFIgGIndexbynephelometryCSFIgG(IgG/TotalProteinas%)Electrophoresis,Protein,serumElectrophoresis,Protein,serumwithimmunoglobulinquantitationsandimmunofixationelectrophoresisElectrophoresis,Protein,24-hoururineorrandomurine:includestotalproteinElectrophoresis,Protein,24-hoururineorrandomurine:includestotalprotein,immunoglobulinquantitationsandimmunofixationelectrophoresisElectrophoresis,BenceJonesProtein,24-hoururineorrandomurineincludestotalproteinandimmunofixationelectrophoresisHaptoglobinbynephelometryIgA,SerumbynephelometryIgG,SerumbynephelometryIgM,SerumbynephelometryPrealbuminbynephelometry几家代表性医院检验科现开展检验项目课件第19页AutoimmuneDiseaseTests本身免疫

ANAScreenwithreflextotiterandpatternforpositivesbyIFAC3bynephelometryC4bynephelometryCyclicCitrullinatedPeptide(CCP)IgGbyEIAdsDNAScreenwithreflextotiterforpositivesbyIFAJo-1antibodybyEIAMitochondrialantibodywithreflextotiterforpositivesbyIFA几家代表性医院检验科现开展检验项目课件第20页RheumatoidFactorbynephelometrySclerodermaantibody(Scl-70)byEIASjogren’santibody(SS-A)byEIASjogren’santibody(SS-B)byEIASmantibodybyEIARNPantibodybyEIASmoothMuscleantibodywithreflextotiterforpositivesbyIFA几家代表性医院检验科现开展检验项目课件第21页InfectiousDiseaseSerologyTests各种传染病细菌学检验

Anti-StreptolysinObynephelometryCMVIgGbyEIACMVIgMbyMEIAEBVIgG(EA,VCA,EBNA)byEIAEBVIgMbyIFAHelicobacterpyloriIgGbyEIAHSVIgGbyEIAHSVIgMbyEIALymeDiseasebyEIAwithreflextoWesternBlotforpositiveandequivocalresults几家代表性医院检验科现开展检验项目课件第22页MononucleosisScreenbyagglutinationMumpsIgGbyEIARubellaIgGbyMEIARubeolaIgG(measles)byEIASyphilisSerologybyRPRwithreflextotiterandFTAifpositiveToxoplasmaIgGbyMEIAToxoplasmaIgMbyMEIAVZV(Varicellazoster)IgGbyEIAVDRLbymicroflocculationWestNileIgMbyEIA几家代表性医院检验科现开展检验项目课件第23页HIV-1p24AntigenTesting(DirectandICD)QualitativeandQuantitativeHIV-1PlasmaandPBMCCultureTestQualitativeDNAPCRTestingQuantitativeHIV-1RNATesting几家代表性医院检验科现开展检验项目课件第24页MolecularDiagnosticsLaboratory

Weprovideamultitudeofclinicaltestingforleukemia,lymphoma,solidtumors,colorectalcancerpredisposition,andhematologicmutations.Leukemia白血病RFLP-Thistestisperformedonbonemarrowtransplant(BMT)patientsandtheirdonorsbeforeBMTtoidentifyaninformativeprobe,andthenafterBMTonthepatienttomonitorthestatusofthegraft.

IgHPCR-ThistestidentifiesB-cellclonalityinleukemiaandlymphoma.

TCR-GammaPCR-ThistestidentifiesT-cellclonalityinleukemiaandlymphoma.

BCR-ABLRT-PCR-Thistestidentifiesthet(9:22)BCR/ablgenetranslocation(Philadelphiachromosome)presentinmorethan99%ofCMLandfrequentlyinall.几家代表性医院检验科现开展检验项目课件第25页Lymphoma淋巴瘤BCL2/IgHPCR-Thistestidentifiesthet(14:18)BCL2/IgHgenetranslocation(majorandminorbreakpointregions)seeninfollicularlymphomaandlargecelllymphoma.Specialtytests特殊检验APCI1307K-ThistestidentifiesthehereditarypredispositionforcolorectalcancerintheAshkenaziJewishpopulation.几家代表性医院检验科现开展检验项目课件第26页Leukemia白血病FlowCytometry(PhenotypicCharacterization,ResidualDiseaseDetection)

MorphologyConsultations--BloodandMarrow

Cytogenetics(incollaborationwiththeCytogeneticsLaboratory)

MolecularDiagnostics(incollaborationwiththeMolecularDiagnosticsLaboratory)Lymphoma淋巴瘤FlowCytometry(PhenotypicCharacterization,Staging,ResidualDiseaseDetection,FineNeedleAspirates)

MorphologyConsultations--LymphNodeandotherTissueBiopsies

Immunohistochemistry

Moleculardiagnostics(incollaborationwiththeMolecularDiagnosticLaboratory)SpecialtyTests特殊检验CD34Counting

PNH(ParoxysmalNocturnalHemoglobinuria)Diagnosis阵发性睡眠性血红蛋白尿几家代表性医院检验科现开展检验项目课件第27页Bacteriology细菌MolecularMicrobiology分子微生物Mycobacteriology结核菌Mycology真菌Parasitology寄生虫Virology病毒几家代表性医院检验科现开展检验项目课件第28页SpecialPathogenDetectionActinomycesspp.:Culture;PCRBordetellapertussis:Culture;

PCRLegionellapneumophila:Culture;Directfluorescentantibody;PCRMycoplasmapneumoniae:PCRMycoplasmahominis/Ureaplasmaurealyticum:CultureBartonellaspp.:Culture;PCRChlamydiapneumoniae:PCRChlamydiatrachomatis:Culture;PCREhrlichia/Anaplasma:PCRBorreliaburgdorferi:Culture;PCRNeisseriagonorrheae:Culture;PCR几家代表性医院检验科现开展检验项目课件第29页BacterialIdentification

Gas-liquidchromatographyofglucosemetabolicendproductsforanaerobeidentification.Cellwallfattyacidanalysisforspeciationofnon-fermentingoruncommonisolates.16SribosomalRNAgenesequenceanalysisforidentification.ToxinTestingStaphylococcusaureusPanton-ValentineleukocidinShiga-liketoxins1and2Clostridiumdifficiletoxinbyantigenandcytotoxicmethods几家代表性医院检验科现开展检验项目课件第30页AntibioticSusceptibilityTestingandMonitoringAgardilutionsusceptibilitytesting(MIC)Antibioticbacteriocidaldetermination(MIC/MBC)Antibioticserumactivity(Schlichtertest-MID/MBD)AntibioticsynergytestingAntibioticserumleveldeterminationsMoleculardeterminationofantibioticresistancegenesMethicillinresistance(mecA)Vancomycinresistance(vanA;vanB;vanC)MolecularEpidemiologyPulsed-fieldgelelectrophoresis(PFGE)Restrictionfragment-lengthpolymorphisms(RFLP)几家代表性医院检验科现开展检验项目课件第31页Epstein-Barrvirus(EBV)detectionandquantificationbyPCR

ParvovirusB19PCRdetectionBKvirusdetectionandquantificationbyPCRJCvirusdetectionbyPCRCytomegalovirus(CMV)PCRdetectionVaricella-Zostervirus(VZV)PCRdetectionHepatitisCvirus(HCV)quantificationbyPCRHCVgenotypeidentificationbydirectsequencingHepatitisBvirusquantificationbyPCR几家代表性医院检验科现开展检验项目课件第32页AdenovirusdetectionbyPCREnterovirusdetectionbyPCRHighRiskHPVdetection(HC-2,Digene)EhrlichiachaffeensisandAnaplasmaphagocytophila(HGEagent)PCRdetectionAtypicalpneumoniapathogendetectionbyPCR(Mycoplasmapneumoniae,Legionellapneumophila,Chlamydiapneumoniae)

Bacterialidentificationby16SribosomalRNAgenesequencingMolecularepidemiologybyPFGEorRFLPStaphylococcusenterotoxinandTSST-1geneandShiga-liketoxingeneidentificationbyPCRBordetellapertussisPCRDetection几家代表性医院检验科现开展检验项目课件第33页几家代表性医院检验科现开展检验项目课件第34页几家代表性医院检验科现开展检验项目课件第35页MycobacteriologyMycobacteriaspeciesidentificationandsusceptibilitytesting,especiallyforpatientswithmultiplyresistantpathogens,isbeyondtheroutinetestingavailableinmosthospitallaboratories.

TheJohnsHopkinsHospitalMycobacteriologyLaboratoryoffersthefollowingtesting:Culture/smearSpeciationMycobacterialbloodcultureRoutinesusceptibilitytestingforM.tuberculosis

Susceptibilitytestingforselectnon-specificmycobacteriauponrequestPCRforM.tuberculosisfromsmearpositiverespiratory(only)specimens

几家代表性医院检验科现开展检验项目课件第36页MycologyMostclinicallaboratoriescanonlyidentifycommonfungi,buttheHospital'sdiversepatientbasegivestheMicrobiologyLaboratoryexperiencetestingforspeciationofunusualorganismsand

forperformingyeastinvitrosusceptibilitytesting.

Fungalidentification(yeast,dimorphics,filamentous)真菌判定Cryptococcusantigendetection(隐球菌抗原检测）Fungalculture（真菌培养）Directmicroscopicexamination（直接镜检）KOHCalcofluorwhite（荧光染色，用于判别孢子虫)Giemsa几家代表性医院检验科现开展检验项目课件第37页Yeastinvitrosusceptibilitytesting酵母菌体外药敏试验AmphotericinB二性霉素BItraconazole伊曲康唑Voriconazole伏立康唑Fluconazole弗康唑5-fluorocytosine5-弗胞嘧啶Caspofungin卡波芬净几家代表性医院检验科现开展检验项目课件第38页Parasitology

TheMicrobiologyLaboratoryhasextensiveexperiencediagnosingproblemsininternationalpopulationsexposedtounfamiliarparasites,cancerpatientswhoareimmune-suppressed,andHIV-infectedpatientswhoarepronetodevelopunusualinfections.Malariaandotherbloodparasitesdetectionandidentification疟原虫和其它血寄生虫判别CryptosporidiumandIsosporaidentification隐孢子虫Microsporidiumssp.identification小孢子虫Pneumocystiscariniiidentification卡氏肺囊虫Giardialambliaidentification肠兰伯式鞭毛虫

几家代表性医院检验科现开展检验项目课件第39页VirologyTheVirologyLaboratorywithintheDivisionofMedicalMicrobiologyusesmanydifferentcelllinesforculture,appliesnewmethodologiesforrapidandearlyidentificationofpathogenicviruses,andperformsviralsusceptibilitydeterminationsrarelyperformedinotherlaboratories.Respiratoryvirus(respiratorysyncytialvirus(RSV),influenzaA,influenzaB,parainfluenzaviruses1-3,adenovirus)rapidantigendetectionandculture呼吸道病毒Herpessimplexculture单纯疱疹

Cytomegalovirus(CMV)culture巨细胞病毒

Cytomegalovirus(CMV)culture--earlyantigenCytomegalovirus(CMV)quantificationbyPCR几家代表性医院检验科现开展检验项目课件第40页Varicella-Zostervirus(VZV)culture水痘-带状疱疹病毒Enterovirusculture肠道病毒Adenovirusculture腺病毒OtherViralcultures其它病毒Viralsusceptibility病毒药敏MolecularVirology(seeMolecularMicrobiology)分子病毒学几家代表性医院检验科现开展检验项目课件第41页

华西医院检验科独特项目几家代表性医院检验科现开展检验项目课件第42页游离脂肪酸（Freefattyacids,FFA）

3-甲氧基-4羟基苦杏仁酸（Vanillylmandelicacid,VMA）

抗酒石酸酸性磷酸酶（Tartrateresistantacidphosphatase-5b,TRAP-5b）

人巨细胞病毒载量（HCMVviralload）

沙眼衣原体DNA（CT-DNA）

淋球菌DNA（NG-DNA）

疱疹病毒I、IIDNA（HSVI&II-DNA）

几家代表性医院检验科现开展检验项目课件第43页HLA抗体特异性试验 （PRA）

HLA抗体筛查试验(HLAI、IIantibodyscreeningtest)

HLA抗原DNA分型（HLAantigendetection）

几家代表性医院检验科现开展检验项目课件第44页解脲支原体DNA（UU-DNA）

B细胞（CD19CD5）

转铁蛋白

(Transferrin，TRF)

骨特异性碱性磷酸酶（β-ALP）

T细胞亚群(CD3,CD4,CD8)

α1抗胰蛋白酶(Alpha1-antitrypsin,AAT)

α1酸性糖蛋(Alpha1AcidGlycoprotein)(AAG)

γ干扰素（IFNγ）

几家代表性医院检验科现开展检验项目课件第45页免疫固定电泳（ImmunofixationElectrophoresis,IFE）可溶性白细胞介素2受体（sIL-2R）

可溶性细胞凋亡因子配体（sFasL）

可溶性细胞凋亡因子（sFas）

可溶性细胞间粘附分子1（sICAM-1）可溶性细胞间粘附分子3（sICAM-3）

可溶性血管粘附分子1（sVCAM-1）

几家代表性医院检验科现开展检验项目课件第46页尿轻链定量（κλ）循环免疫复合物（circulatingimmunecomplex,CIC）

抗凝血酶3(AntithrombinⅢ,AT3)

新碟呤（Neopterin）白细胞介素-2（IL-2）4,6,8,10,12,13结合珠蛋白(Haptoglobin，HPT)

自然杀伤细胞（NaturalKillerCells,NK）

几家代表性医院检验科现开展检验项目课件第47页血管内皮生长因子（VEGF）肝纤PCⅢCⅣLNHAMAOFN

ALA*δ-氨基-γ酮戊酸（δ-aminolevulinicacid,ALA）亮氨酰氨基肽酶（leucineaminopeptidase，LAP）

冷球蛋白（cryoglobulinscryo）

酸性磷酸酶（acidphosphatase，ACP）

几家代表性医院检验科现开展检验项目课件第48页磷脂（phospholipid，PL）

VWF胶原结合分析（vWFcollogenbindingassay

）

vWF抗原测定(vWFantigendetermination)

X因子活性测定(factorXactivitydetermination

Ⅱ因子活性测定(factorIIactivitydetermination

几家代表性医院检验科现开展检验项目课件第49页Ⅶ因子活性测定(factorVIIactivitydetermination)

Ⅷ因子活性测定(factorVIIIactivitydetermination)Ⅸ因子活性测定(factorIXactivitydetermination)

抗碱血红蛋白(Alkali-resistanthemoglobin)

血红蛋白电泳和HbA2测定（hemoglobinelectrophoresisandmensurationforHbA2）

几家代表性医院检验科现开展检验项目课件第50页高铁血红蛋白还原试验(methemoglobinreductiontest)

几家代表性医院检验科现开展检验项目课件第51页

北京协和医院检验科项目几家代表性医院检验科现开展检验项目课件第52页达安基因目录几家代表性医院检验科现开展检验项目课件第53页美国每年医学试验室检验70-100亿个标本其中TCT2.4亿，组织病理6千万个大于97%癌症经过组织活检确诊，而不是肿瘤标志物，中华医学会检验分会肿瘤标志物委员会和美国NIH都有文件明确指出：肿瘤标志物不能用于肿瘤普查几家代表性医院检验科现开展检验项目课件第54页国家发改委已明确表示今后医疗付费模式是按病种付费医疗机构与医保部门讨价还价是临床路径临床路径实施结果是今后大组合和与诊疗关系不大项目必定萎缩几家代表性医院检验科现开展检验项目课件第55页IOM汇报每年医疗事故：科罗拉多州和犹他州44000例死亡，纽约州98000例死亡每年医疗事故造成死亡人数，超出车祸（44000），乳腺癌（43000）和艾滋病（17000）总和经济损失美元170-290亿几家代表性医院检验科现开展检验项目课件第56页质量确保是基础，包含设备/试剂HepatitisBsurfaceantigenmutantdetectiononfourimmunoassayanalysers.ARCHITECTi

AXSYM

Elecesys

Vitros

Mutantdetection12/1212/127/126/12Turn-aroundtime30m30m20m38mCalibtationstability28d23d28d28dCostperreportable(us)2.192.381.941.88ThefivediscordantmutantswerePro142-Ser+Gly145-Arg;Gly145-ARG;Asp144-Ala+Gly145-Arg;Thr126-Ser+Gly145-Arg;Pro142-Leu+Gly145-ArgS.L.Saw,etal.NationalUniversityHospitalSingapor几家代表性医院检验科现开展检验项目课件第57页个体化医疗关键---分子诊疗分子诊疗较传统诊疗能够更早诊疗疾病几家代表性医院检验科现开展检验项目课件第58页分子诊疗

蛋白水平免疫组化流式细胞学免疫荧光/电镜核酸水平遗传学原位杂交PCRMicroarray测序几家代表性医院检验科现开展检验项目课件第59页当今有明确应用有乳腺癌：FISH查HER2/NEU淋巴瘤：IgM和T细胞受体基因重排遗传性非息肉性结肠癌：肺癌：EGFR脑瘤：1p/19q丢失转移相关肉瘤PCR诊疗微卫星不稳定性几家代表性医院检验科现开展检验项目课件第60页传统检测DNA策略遗传学（筛查，screening)大插入/缺失，扩增，易位几家代表性医院检验科现开展检验项目课件第61页原位杂交（选择，selection)大插入/缺失，扩增，易位几家代表性医院检验科现开展检验项目课件第62页基于PCR方法突变，小插入/缺失，重复改变，大插入/缺失，扩增，易位几家代表性医院检验科现开展检验项目课件第63页新DNA检测策略微阵列（选择，selection)不能发觉未知基因几家代表性医院检验科现开展检验项目课件第64页测序（筛查，screening)不适合发觉插入/缺失，扩增，易位几家代表性医院检验科现开展检验项目课件第65页遗传检测类型诊疗性检验携带者检验预测性检验产前检测和植入前检验分子靶点：DNA突变，基因组改变，多态性几家代表性医院检验科现开展检验项目课件第66页范例FactorVLeiden/凝血酶原（诊疗）囊性纤维化病（诊疗，携带者，产前）脊髓型肌萎缩诊疗（产前）、携带者，连锁老年性痴呆：微管相关蛋白tau(MAPT)突变分析UGT1A1多态性分析（遗传药理学）几家代表性医院检验科现开展检验项目课件第67页血液学应用诊疗微小残留预后移植前评定和分期（详见WHO肿瘤分类）几家代表性医院检验科现开展检验项目课件第68页CDA基因多态性预测胞嘧啶核苷类似物治疗效果及毒性JAK2突变慢性骨髓增殖性疾病（MPD）主要诊疗指标BCR-ABL融合基因经干扰素、伊马替尼治疗，评价CML预后PML-RARA融合基因经全反式维甲酸及三氧化二砷等治疗后，评价APL预后AML1-ETO融合基因AML患者预后评价TEL-AML1融合基因预测ALL治疗和预后几家代表性医