Phycocyanobilin-DataSheet-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEPhycocyanobilinCat.No.:HY-130750CASNo.:20298-86-6分⼦式:C₃₃H₃₈N₄O₆分⼦量:586.68作⽤靶点:ReactiveOxygenSpecies作⽤通路:Immunology/Inflammation;MetabolicEnzyme/Protease;NF-κB储存⽅式:4°C,protectfromlight*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light)溶解性数据体外实验DMSO:<1mg/mL(ultrasonic;heatto60°C)(insolubleorslightlysoluble)请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(protectfromlight)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性Phycocyanobilin⼀种具有⼝服活性的抗氧化剂(reactiveoxygenspecies)，⼀种有效的活性氧除剂。Phycocyanobilin可⽤于阿尔茨海默病的研究。体外研究Phycocyanobilin(100μM;0-250min)inhibitstheperoxidationofmethyllinoleateandproducesaprolongedinductionperiod[1].Phycocyanobilin(1mM;0-300min)suppressestheoxidationoftheliposomes[1].体内研究Phycocyanobilin(15mg/kg;p.o.;indietfor2weeks)showsantioxidanteffectsintype2diabetesmice[3].AnimalModel:MaleC57BL/KsJdb/dbmice,arodentmodelfortype2diabetes[3]Dosage:15mg/kgAdministration:Indietfor2weeks1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEResult:Significantlydecreasedbloodglucoselevels.Normalizedtheincreasesinurinary8-OHdGand8-epi-PGF2αlevels,renaloxidativestressmarkersevaluatedbyrenal8-OHdGstainingandDHEstaining,Nox4mRNA,andproteinexpression,aswellasthemRNAlevelsofotherNAD(P)Hoxidasecomponents,inflammatorymarkersandHO-1.REFERENCES[1].HirataT,etal.AntioxidantactivitiesofphycocyanobilinpreparedfromSpirulinaplatensis.JournalofAppliedPhycology,2000,12:435-439.[2].MatamorosBP,etal.NutraceuticalandtherapeuticpotentialofPhycocyanobilinfortreatingAlzheimer'sdisease.JBiosci.2021;46:42.[3].ZhengJ,etal.PhycocyaninandphycocyanobilinfromSpirulinaplatensisprotectagainstdiabeticnephropathybyinhibitingoxidativestress.AmJPhysiolRegulIntegrCompPhysiol.2013Jan15;304(2):R110-20.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Te