生理学教学课件：内分泌

lovehormoneoxytocinVincentduVigneaud(May18,1901–December11,1978)wasanAmericanbiochemist.HewonaNobelPrizeinChemistryin1955fortheisolation,structuralidentification,andtotalsynthesisofthecyclicpeptide,oxytocin

Prof.Dr.UrsFischbacher-Director自闭症

Oxytocin

enhancesbrainfunctionin

children

with

autism.ProcNatlAcadSciUSA.2013Dec24;110(52):20953-8魔术How

magic

changesourexpectationsabout

autismPsycholSci.2010Oct;21(10):1487-93.$59.95

OxytocinincreasesgenerosityinhumansZakPJ,StantonAA,AhmadiS.PLoSOne.2007Nov7;2(11):e1128.OxytocinincreasestheinfluenceofpublicserviceadvertisementsLinPY,GrewalNS,MorinC,JohnsonWD,ZakPJ.PLoSOne.2013;8(2):e56934.Journal2012IFScience231.2Nature136.3Natureneuroscience215.5Naturereviewneuroscience130.4Naturereviewurology14.4Neuron314.7PNAS310.3Journalofneuroscience57.1CurbingfearbyaxonaloxytocinreleaseinamygdalaNeuron2012Prader-Willisyndrome

Oxytocin

inhibits

food

and

fluid

intake

in

ratsPhysiolBehav.1990Dec;48(6):825-30Alterations

inthe

hypothalamicparaventricularnucleus

andits

oxytocin

neurons

(putativesatietycells)inPrader-Willisyndrome:astudyoffivecasesJClinEndocrinolMetab.1995Feb;80(2):573-9DeconstructionofaneuralcircuitforhungerNature2012TheadventuresofPinocchioAngelman'ssyndromeOxytocinMakesAttachedMenStayAwayfromOtherWomen

2012JournalofneuroscienceOxytocin

enhances

brain

reward

system

responses

in

men

viewing

the

face

oftheir

female

partner.ProcNatlAcadSciUSA.2013Dec10;110(50):20308-13.2012-10-26DoesSingingPromoteWell-Being?AnEmpiricalStudyofProfessionalandAmateurSingersduringaSingingLessonGrapeC,SandgrenM,HanssonLO,EricsonM,TheorellT.IntegrPhysiolBehavSci.2003Jan-Mar;38(1):65-74.ILoveyoumorethanIcansayWowwowyeayeaIloveyoumorethanIcansayI'llloveyoutwiceasmuchtomorrowWowILoveyoumorethanIcansayOhdon'tyouknowIneedyousoOhtellmepleaseIgottaknowDoyoumeantomakemecryAmIjustanotherguyWowwowyeayeaImissyoueverysingledayWhymustmylifebefilledwithsorrowWowImissyoumorethanIcansayWowwowyeayeaIloveyoumorethanIcansayWhymustmylifebefilledwithsorrowWowIloveyoumorethanIcansay1423Oxytocinandthelife-spanofmaleratsBodanszkyM,EngelSL.Nature.1966May14;210(5037):751.NNaturemedicine2007:exercise-inducedVGFexpressionwhichisbeneficialHypertension2012:aerobicexercisedecreasebloodNeuropsychopharmacology1999:exerciseincreaseBDNF

yogurtSerendipityPeterAgre

Born30January1949(age

65)

Northfield,Minnesota,USANationalityUnitedStatesFieldsChemistryAlmamaterAugsburgCollege,JohnsHopkinsSchoolofMedicine,CaseWesternReserveUniversityKnown

forAquaporinsNotableawardsNobelPrizeinChemistry,2003Veryniceperson,knownforhumanityandhumilityD-gradeMicrobialSymbiontsAccelerateWoundHealingviatheNeuropeptideHormoneOxytocinPoutahidisT,KearneySM,LevkovichT,QiP,VarianBJ,LakritzJR,IbrahimYM,ChatzigiagkosA,AlmEJ,ErdmanSE.PLoSOne.2013Oct30;8(10)gutmicrobe-brain-immuneaxisOxytocicplantcyclotidesastemplatesforpeptideGprotein-coupledreceptorliganddesignPNAS.2013Nov18.中医里有类似的药吗?

Castor

oil

induces

laxation

and

uterus

contraction

via

ricinoleic

acid

activating

prostaglandin

EP3receptorsProcNatlAcadSciUSA.2012Jun5;109(23):9179-84.中国最早的医学书籍是哪本,你知道吗?<<Eberspapyrus>>Peripheral(hormonal)actionsLetdownreflexUterinecontractionSocialbehaviorandwouldhealingTherelationshipbetweenoxytocinandhumansexualresponseAutis