Ifenprodil-tartrate-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEIfenprodiltartrateCat.No.:HY-12882ACASNo.:23210-58-4分⼦式:C₂₁H₂₇NO₂.₁/₂C₄H₆O₆分⼦量:400.49作⽤靶点:iGluR;PotassiumChannel作⽤通路:MembraneTransporter/IonChannel;NeuronalSignaling储存⽅式:4°C,sealedstorage,awayfrommoisture*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoisture)溶解性数据体外实验DMSO:≥500mg/mL(1248.47mM)H2O:5mg/mL(12.48mM;Needultrasonic)*"≥"meanssoluble,butsaturationunknown.MassSolvent1mg5mg10mgConcentration制备储备液1mM2.4969mL12.4847mL24.9694mL5mM0.4994mL2.4969mL4.9939mL10mM0.2497mL1.2485mL2.4969mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoisture)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：0.5%CMC-Na/salinewaterSolubility:12.22mg/mL(30.51mM);Suspendedsolution;Needultrasonic1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE2.请依序添加每种溶剂：1%DMSO>>99%salineSolubility:≥1mg/mL(2.50mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性Ifenprodiltartrate典型的⾮竞争性NMDA受体拮抗剂。Ifenprodiltartrate对NR1A/NR2B受体亲和⼒(IC50=0.34μM)NR1A/NR2A受体的400倍(IC50=146μM)。Ifenprodiltartrate抑制GIRK(Kir3)，通过基底GIRK活性减少内向电流。Ifenprodiltartrate有潜能⽤做脑⾎管舒张试剂。IC50&TargetIC50:0.34μM(NR1A/NR2Breceptor);146μM(NR1A/NR2Areceptor)[1]体外研究Gprotein-activatedinwardlyrectifyingK+channels(GIRK)[1].户使⽤本产品发表的科研⽂献•Chemosphere.2019Aug;229:618-630.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].WilliamsK,etal.IfenprodildiscriminatessubtypesoftheN-methyl-D-aspartatereceptor:selectivityandmechanismsatrecombinantheteromericreceptors.MolPharmacol.1993Oct;44(4):851-9.[2].KobayashiT,etal.InhibitionofGprotein-activatedinwardlyrectifyingK+channelsbyifenprodil.Neuropsychopharmacology.2006Mar;31(3):516-24.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly