TXNIP-IN-1-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemETXNIP-IN-1Cat.No.:HY-115688CASNo.:1268955-50-5分⼦式:C₁₂H₁₂N₂O₄分⼦量:248.23作⽤靶点:Others作⽤通路:Others储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:50mg/mL(201.43mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM4.0285mL20.1426mL40.2852mL5mM0.8057mL4.0285mL8.0570mL10mM0.4029mL2.0143mL4.0285mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.5mg/mL(10.07mM);Clearsolution1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.5mg/mL(10.07mM);Clearsolution3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(10.07mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性TXNIP-IN-1⼀种硫氧还蛋⽩-硫氧还蛋⽩相互作⽤蛋⽩(TXNIP-TRX)复合物抑制剂，详细信息请参考专利⽂献US20200085800A1中的化合物1。TXNIP-IN-1可⽤于TXNIP-TRX复合物相关代谢紊乱(糖尿病)、⼼⾎管疾病或炎症疾病的研究[1]。IC50&TargetTXNIP-TRXcomplex[1]体外研究TXNIP-IN-1bockshighglucose(HGinduced)TXNIP-TRXcomplexformation[1].TXNIP-IN-1(1.25-5μM)reducesHG-inducedexpressionofTNFinmonocytes[1].TXNIP-IN-1(1.25-5μM;72hours)inhibitsTXNIPmRNAexpressioninTHP1cells[1].TXNIP-IN-1(0.3-10μM;72hours)inhibitsTXNIPmRNAexpressioninmurineRAWmacrophages[1].TXNIP-IN-1(5-20μM;72hours)decreasesTXNIPbutnotTNF-alphamRNAlevelsinMIN6cells[1].TXNIP-IN-1(0.62-5μM;72hours)affectsTXNIPandTNF-alphamRNAexpressioninhumanpancreas1.1B4betacells[1].TXNIP-IN-1(5μM;16-72hours)inhibitsc-TRXinteractioninTHP1cellsculturedin25mMglucose[1].TXNIP-IN-1targetsTXNIPmRNAinhumanpancreaticislets[1].户使⽤本产品发表的科研⽂献•Diseases.2021Dec14;9(4):91.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].RamaNatarajan,etal.Txnip-trxcomplexinhibitorsandmethodsofusingthesame.US20200085800A1.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchu