Vafidemstat-ORY-2001-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEVafidemstatCat.No.:HY-112623CASNo.:1357362-02-7Synonyms:ORY-2001分⼦式:C₁₉H₂₀N₄O₂分⼦量:336.39作⽤靶点:HistoneDemethylase;MonoamineOxidase作⽤通路:Epigenetics;NeuronalSignaling储存⽅式:Powder-20°C3yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:50mg/mL(148.64mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.9727mL14.8637mL29.7274mL5mM0.5945mL2.9727mL5.9455mL10mM0.2973mL1.4864mL2.9727mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:5mg/mL(14.86mM);Suspendedsolution;Needultrasonic1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:5mg/mL(14.86mM);Suspendedsolution;Needultrasonic3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥5mg/mL(14.86mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性Vafidemstat(ORY-2001)⼀种有效的，具有⼝服活性的，可透过⾎脑屏障的，双重的赖氨酸特异性组蛋⽩去甲化酶(LSD1)/MAO-B抑制剂[1]。IC50&TargetLSD1/MAO-B[1]体外研究Vafidemstat(ORY-2001),adualLSD1/MAO-Binhibitor,isanovelepigeneticagentforthetreatmentofneurodegenerativediseases.LSD1isaproteinthatparticipatesintranscriptionregulationcomplexes;itsmodulationcanbeusedtotweaktranscriptionalimbalancesinneurodegenerativediseaseandredressneuroinflammationandcognitivedeficit[1].Vafidemstat(ORY-2001)canbeusedinthetreatmentofAlzheimer'sdisease[2].REFERENCES[1].ORYZONpresentsdataonthePhaseItrialwithORY-2001atthe13thInternationalConferenceonAlzheimer’sandParkinson’sdiseases[2].ORYZONReportsFinancialResultsandCorporateUpdateforthe1stHalfEndedJune30,2018.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel