BRD-K98645985-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEBRD-K98645985Cat.No.:HY-114268CASNo.:1357647-78-9分⼦式:C₃₃H₄₃N₅O₄分⼦量:573.73作⽤靶点:HIV作⽤通路:Anti-infection储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:250mg/mL(435.75mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.7430mL8.7149mL17.4298mL5mM0.3486mL1.7430mL3.4860mL10mM0.1743mL0.8715mL1.7430mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.08mg/mL(3.63mM);Clearsolution1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:2.08mg/mL(3.63mM);Suspendedsolution;Needultrasonic3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.08mg/mL(3.63mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性BRD-K98645985⼀种BAF(mammalianSWI/SNF)转录阻遏的抑制剂，EC50为~2.37µM。BRD-K98645985结合ARID1A特异的BAF复合物，防⽌核⼩体定位，并有效逆转HIV-1潜伏期，并且⽆T细胞毒性。IC50&TargetBAFtranscriptionalrepressionHIV-12.37μM(EC50)体外研究BRD-K98645985(30µM;18hours)treatmentshowsa5-foldincreaseinBmi1,2.6-foldincreaseinRing1,and3.3-folddecreaseinFgf4[1].BRD-K98645985treatmentshowsaconcentrationdependentlatencyreversalinJ-LatT-celllinemodels.BRD-K98645985canbecombinedwithotherLRAstoimprovereservoirtargeting[1].户使⽤本产品发表的科研⽂献•Nature.2022Jul;607(7917):135-141.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].MarianCA,etal.SmallMoleculeTargetingofSpecificBAF(mSWI/SNF)ComplexesforHIVLatencyReversal.CellChemBiol.2018Dec20;25(12):1443-1455.e14.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel: