SGC3027-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemESGC3027Cat.No.:HY-112445CASNo.:2624313-13-7分⼦式:C₄₁H₄₇ClN₆O₆S分⼦量:787.37作⽤靶点:HistoneMethyltransferase作⽤通路:Epigenetics储存⽅式:Powder-20°C3yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:250mg/mL(317.51mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.2701mL6.3503mL12.7005mL5mM0.2540mL1.2701mL2.5401mL10mM0.1270mL0.6350mL1.2701mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性SGC3027⼀种组蛋⽩甲转移酶抑制剂[1]。SGC3027第⼀个有效，选择性，具有细胞活性的PRMT7化学探针[2]。IC50&TargetPRMT7[1][2]体外研究SGC3027isapro-drugofSGC8158whichreleasestheactivecomponentuponreductioninthecellby1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEreductases.IncellularassaysusingC2C12cells,SGC3027inhibitsthemethylationofHSP70withIC50=1.3μM[2].户使⽤本产品发表的科研⽂献•MolCell.2021Aug5;81(15):3171-3186.e8.•NatCommun.2021Mar29;12(1):1946.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].CermakovaK,etal.Next-GenerationDrugsandProbesforChromatinBiology:FromTargetedProteinDegradationtoPhaseSeparation.Molecules.2018Aug6;23(8).pii:E1958.[2].SGC3027forPRMT7.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax: