Guanosine-5-diphosphate-disodium-salt-GDP-disodium-salt-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEGuanosine5'-diphosphatedisodiumsaltCat.No.:HY-113066ACASNo.:7415-69-2Synonyms:GDPdisodiumsalt分⼦式:C₁₀H₁₃N₅Na₂O₁₁P₂分⼦量:487.16作⽤靶点:EndogenousMetabolite;PotassiumChannel作⽤通路:MetabolicEnzyme/Protease;MembraneTransporter/IonChannel储存⽅式:-20°C,sealedstorage,awayfrommoisture*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoisture)溶解性数据体外实验H2O:125mg/mL(256.59mM;Needultrasonic)DMSO:<1mg/mL(ultrasonic;warming;heatto80°C)(insolubleorslightlysoluble)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.0527mL10.2636mL20.5271mL5mM0.4105mL2.0527mL4.1054mL10mM0.2053mL1.0264mL2.0527mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoisture)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE1.请依序添加每种溶剂：PBSSolubility:100mg/mL(205.27mM);Clearsolution;NeedultrasonicBIOLOGICALACTIVITY⽣物活性Guanosine5'-diphosphate(GDP)disodiumsalt⼀种核苷⼆磷酸，可激活5'-三磷酸腺苷敏感的K+通道。Guanosine5'-diphosphatedisodiumsalt⼀种潜在的铁动员剂，可阻断铁调素-铁转运蛋⽩(hepcidin-ferroportin)相互作⽤并调节IL-6/stat-3通路。Guanosine5'-diphosphatedisodiumsalt可⽤于炎症研究，如炎症性贫⾎(AI)。IC50&TargetHumanEndogenousMetabolite户使⽤本产品发表的科研⽂献•IntJMolSci.2022Oct27;23(21):13058.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].SKajioka,etal.Guanosinediphosphateactivatesanadenosine5'-triphosphate-sensitiveK+channelintherabbitportalvein.JPhysiol.1991Dec;444:397-418.[2].AngmoS,etal.IdentificationofGuanosine5'-diphosphateasPotentialIronMobilizer:PreventingtheHepcidin-FerroportinInteractionandModulatingtheInterleukin-6/Stat-3Pathway.SciRep.2017Jan5;7:40097.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel