Antibacterial-agent-121-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEAntibacterialagent121Cat.No.:HY-151354CASNo.:474099-18-8分⼦式:C₁₈H₂₂N₂O₃S分⼦量:346.44作⽤靶点:Bacterial作⽤通路:Anti-infection储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Antibacterialagent121(Compound10)⼀种抗剂。Antibacterialagent121具有抗霉和抗炎的活性，可⽤于肺结核相关研究。体外研究Antibacterialagent121(0.2-200µM;24h)inhibitsM.tuberculosisH37Rvgrowthinbacterialculture[1].Antibacterialagent121(0-200µM;24h)inhibitsNOproductioninLPS-stimulatedRAW264.7cellcultureswithanIC50valueof4.1µM[1].Antibacterialagent121(6.25-200µM,24h)inhibitsTNF-αandIL-1βproductioninLPS-stimulatedmacrophages[1].Antibacterialagent121(25-100µM,4d)inhibitsM.tuberculosisM299withanMIC50valueof24.8µM[1].CellViabilityAssay[1]CellLine:M.tuberculosisH37RvConcentration:0.2-200µMIncubationTime:24hoursResult:InhibitedMtbH37RvgrowthwithMIC50of8.6µM.CellViabilityAssay[1]CellLine:RAW264.7macrophagesandJ774A.1macrophagesConcentration:6.25-200µM1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEIncubationTime:24hoursResult:ShowedIC50valuesof15.3µMand28.4µMforTNF-αandIL-1βproduction,respectively.REFERENCES[1].SandersonDiasCalixto,etal.Antimycobacterialandanti-inflammatoryactivitiesofthioureaderivativesfocusingontreatmentapproachesforseverepulmonarytuberculosis.BioorgMedChem.2022Jan1;53:116506.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58955