Synaptamide-Dehydroepiandrosteron-DHEA-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemESynaptamideCat.No.:HY-100197CASNo.:162758-94-3Synonyms:Dehydroepiandrosteron(DHEA);Docosahexaenoylethanolamide分⼦式:C₂₄H₃₇NO₂分⼦量:371.56作⽤靶点:CannabinoidReceptor作⽤通路:GPCR/GProtein;NeuronalSignaling储存⽅式:Solution,-20°C,2years*Insolvent:-80°C,6months;-20°C,1month(2years)溶解性数据体外实验Ethanol:25mg/mL(67.28mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.6914mL13.4568mL26.9136mL5mM0.5383mL2.6914mL5.3827mL10mM0.2691mL1.3457mL2.6914mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性Synaptamide(Dehydroepiandrosteron;DHEA)⼀种内性代谢物，Anandamide的结构类似物。Synaptamide与⼤⿇素-1和2(CB1和CB2)⼤⿇素受体结合并具有抗炎特性。Synaptamide第⼀个粘附G蛋⽩偶联受体(aGPCR)的⼩分⼦内性配体。体外研究Synaptamide(Dehydroepiandrosteron;DHEA)isaweakagonistatbothCB1andCB2receptors[2].1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE体内研究Synaptamide(10mg/kg;subcutaneously;dailyfor7days)promotescognitiverecoveryinratssubjectedtomildtraumaticbraininjury(mTBI)[1].Synaptamide(2-10mg/kg;adultmaleC57BL/6Jmice)reducedthelevelsofnociceptiveandinflammatorypain-relatedbehaviourover60minintheintraplantarformaldehydeassayviabothintraperitonealandlocalintraplantaradministration[2].AnimalModel:MaleWistarrats;260ꢀ±ꢀ20g,age3months;mTBImodel)[1]Dosage:10mg/kgAdministration:Subcutaneously;dailyfor7daysResult:ReversedthemTBI-inducedcognitivedeficits.户使⽤本产品发表的科研⽂献•EcotoxicolEnvironSaf.2021Feb25;214:112005.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].KimHY,etal.Synaptamide,endocannabinoid-likederivativeofdocosahexaenoicacidwithcannabinoid-independentfunction.ProstaglandinsLeukotEssentFattyAcids.2013Jan;88(1):121-5.[2].RashidMA,etal.N-Docosahexaenoylethanolamineisapotentneurogenicfactorforneuralstemcelldifferentiation.JNeurochem.2013Jun;125(6):869-84.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.