ChaerConneciveissuerooer固有结缔组织

CONNECTIVETISSUEPROPERGeneralhistologyIntroduction&CellTissueEpitheliumConnectivetissueConnectivetissueproperCartilage&boneBloodMuscletissueNervetissueSpecialhistologyOrgan&systemThecirculatorysystemTheimmunesystemTherespiratorysystemDigestivetractDigestiveglandsTheendocrinesystemTheurinarysystemThemalereproductivesystemThefemalereproductivesystemINTRODUCTIONConnectiveTissue(CT)GeneralFeaturesFewercells,moreextracellularmatrixNopolarityRichinbloodvesslesFunctions:connection,support,protection,INTRODUCTIONCToriginatesfromthemesenchyme,anembryonictissueformedbymesenchymalcellsandamorphousmatrix无定形基质.MesenchymalcellINTRODUCTIONCT（inwidesense）CTproper（innarrowsense）CartilageBoneBloodLooseCTDenseCTAdiposetissueReticulartissueLOOSECONNECTIVETISSUELooseConnectiveTissue(LCT)–Areolar蜂窝TissueFeatures:moretypesofcellsandfewerfibersLOOSECONNECTIVETISSUELooseConnectiveTissueconsistsofCells:fibroblast成纤维细胞,plasmacell浆细胞,macrophage巨噬细胞,mastcell肥大细胞,fatcell,undifferentiatedmesenchymalcell,leukocyte['lʊkə,saɪt]白细胞.ExtracellularmatrixFiber:collagenousfiber,elasticfiber,reticularfiberGroundsubstanceLCTCELLCell:建：undifferentiatedmesenchymalcell成：fibroblast巨：macrophage大：mastcell白：leukocyte浆：plasmacell肪：fatcellDescribethestructureofacellLMShapeNucleus细胞核:nucleolus核仁Cytoplasm细胞质EMOrganelles[,ɔːgə'nel细胞器Granules[grænju:ls]颗粒FibroblastThemostcommoncellsinLCTLM:FlatwithprocessesNucleus:large,palestained着着色浅,withprominentnucleolus核仁仁明显Cytoplasm:slightlybasophilic[,besə‘‘fɪlɪk嗜嗜碱性EM:richinrER,freeribosomes'raɪɪbəsom]andGol.FUNCTION:synthesizefibersandmatrixLCTCELLFIBROBLASTFibroblast(HE)LCTCELLFIBROBLASTFibroblast(TEM)LCTCELLFIBROBLASTFibrocyte:aninactivestatus静静止状态态offibroblastwhichcandevelopintofibroblastforrepairingFibrocyteFibroblastLCTCELLPLASMACELLPlasmaCell※※DerivedfromBlymphocyteLM:ovoidorroundinshape.Roundeccentrically-locatednucleuswithwheel-arrangedheterochromatin.Cytoplasmisabundantandintenselybasophilic.EM:richinrER,freeribosomesandGol.Function:synthesizeandsecrete分分泌immunoglobulins[,ɪmjəno‘glɑbjələn](antibodies),takingpartinhumoralimmunity[ɪ'mjuːːnɪtɪ]体液免疫疫.PlasmaCell（TEM））Macrophage巨噬DerivedfrommonocyteinbloodLM：Shape:irregularwithshortprocessesNucleus:small,darklystainedCytoplasm:acidophilic,withgranules巨噬颗颗粒ofvarioussizesEM:numerousmicrovilli,richinlysosomes,phagosomes,phagocyticvacuoleandresidualbodyFunction:Chemotaxis；Phagocytosis吞噬作用用Secretion；；ImmunereactionLCTCELLMACROPHAGEMacrophageHistocyte:macrophageinLCTMacrophage(TEM)MacrophageMacrophageMastCellDistributedaroundvesselsStructure:Large,roundorovoidNucleus:smallandpale-stainedCytoplasm:filledwithnumerouscoarsemetachromatic易染性granules.Function:thegranulescontainheparin肝素,histamine组组胺andeosinophilchemotacticfactors嗜嗜酸性趋趋化因子子,andthecytoplasmcontainsleukotriene白三三烯,takingpartinallergicreactions过过敏发应应.LCTCELLMASTCELLMastCellMastCell(TEM)LCTCELLFATCELLFatCell(Adipocyte)StructureLarge,roundorpolygonalEccentric,flattenednucleusAthinrimofcytoplasmAlargelipiddropletFunction:synthesizeandstorefatWhiteadiposetissueHELCTCELLUndifferentiatedMesenchymalCellStructure:similartofibrocyteFunction:withdifferentiatingpotentialLeukocytesNeutrophil,eosinophilandlymphocyteLCTFIBERFiber:synthesizedbyfibroblastCollagenous[kə'lædʒənəs]fiber胶原纤纤维ElasticfiberReticularfiberLCTFIBERCOLLAGENOUSFIBERCollagenous[kə'lædʒənəs]Fiber(Whitefiber)LM:Thick、AcidophilicEM:parallel-arrangedcollagenousfibrils胶原原原纤维Collagenousfibril:Withperiodiccrossstriation周周期性性横纹纹at64nmintervalComponent成分分:typeⅠⅠandⅢⅢcollagensMechanicalProperty:greattensilestrengthCollagenousFiberElasticFiberCollagenousFiber（MuscleTendonHE））CollagenousFibril(EM)LCTFIBERELASTICFIBERElasticFiber(yellowfiber)LM:ThinSlightred(HE),purple(aldehydefuchsin)orbrown(orcein)EM:Elastin+MicrofibrilMechanicalProperty:greatelasticityMolecularbasisofelasticityCollagenousFiberElasticFiberLargeArteryLCTFIBERRETICULARFIBERReticularFiberLM:Thin；；BranchtoformnetworksArgyrophilfiber(silverstaining)；；PAS(+)EM:Component:typeⅢⅢcollagen64nmcrossstriationsDistribution:ReticulartissueConnectingportion,e.g.reticularlaminaReticularFiber←（LymphNode，，silverstaining）←←LCTGROUNDSUBSTANCEGroundSubstanceAmorphouscolloidalsubstanceConsistsofGlycosaminoglycan糖糖胺胺多多糖糖Proteoglycan蛋蛋白白多多糖糖Multiadhesiveglycoprotein多多黏黏多多糖糖Tissuefluid组组织织液液LCTGROUNDSUBSTANCEGLYCOSAMINOGLYCANGlycosaminoglycans(GAGs)SulfatedChondroitinsulfateA,C硫硫酸酸软软骨骨素素Keratansulfate硫硫酸酸角角质质素素Heparansulfate硫硫酸酸乙乙酰酰肝肝素素Dermatansulfate硫硫酸酸皮皮肤肤素素NonsulfatedHyaluronicacid(hyaluronan)透明明质质酸酸LCTGROUNDSUBSTANCEPROTEOGLYCANProteoglycanA.Proteoglycansubunit1Coreprotein4GAGsTesttubebrushlikeCoreproteinGAGsLCTGROUNDSUBSTANCEPROTEOGLYCANProteoglycanB.ProteoglycanaggregateCoreproteinHyaluronicacid透透明质质酸ProteoglycansubunitLinkprotein连连接蛋蛋白ProteoglycansubunitCollagenousfibrilMolecularsieveLCTGROUNDSUBSTANCEMULTIADHESIVEGLYCOPROTEINMultiadhesiveGlycoprotein多多黏多糖糖Fibronectin,FN纤纤维粘粘连蛋白白Laminin,LN层层粘粘连蛋白白Chondronectin,ChN软软骨骨粘连蛋蛋白LCTGROUNDSUBSTANCETISSUEFLUIDTissueFluidDENSECONNECTIVETISSUEDenseConnectiveTissue(DCT)Features:fewercells,morefibersFunction:connectionandsupportingThreetypesDenseregularconnectivetissueDenseirregularconnectivetissueElastictissue※※DistributionDCTDENSEREGULARCONNECTIVETISSUEDenseregularconnectivetissueStructure:Parallel-arrangedcollagenousfibersTendoncells:specialfibroblastwithwing-likeprocessesDistribution:TendonsLigamentsDenseregularconnectivetissue,H&ETC:nucleioftendoncellDCTDENSEIRREGULARCONNECTIVETISSUEDenseirregularconnectivetissueStructureFibersarearrangedinbundleswithoutadefiniteorientation.FibroblastLessgroundsubstanceDistribution:dermis,scleraandcapsuleofsomeorgansDenseirregularconnectivetissue(dermis)H&EDCTELASTICTISSUEElastictissueElasticfibersarearrangedinbundlesorformamembraneDistribution:nuchalligament,ligamentumflavumandlargearteryLargearteryADIPOSETISSUEAdiposetissueComposedoffatcells,separatedbyLCT2types:WhiteadiposetissueBrownadiposetissueADIPOSETISSUEWhiteadiposetissueDistribution:subcutaneoustissueUnilocularfatcell:alargelipiddroplet,eccentric,flattenednucleus,arimofcytoplasmFunction:energystorageWhiteadiposetissueHEADIPOSETISSUEBrownadiposetissueDistribution:newbornandhibernatinganimalsMultilocularfatcell:numerouslipiddroplet,roundnucleusinthecenterFunction:Heatproduction(thermogenesis)ADIPOSETISSUERETICULARTISSUEReticulartissueDistribution:hemopoietictissueandlymphatictissueReticularcell：Reticularfiber:GroundsubstanceProvideflexiblesupportandpredominatesinthevertebralcolumn’sligamentaflavaandthesuspensoryligmengofthepenis.SchematicdiagramofreticulartissueMacrophageLymphocyteReticularfiberReticularcellReticulartissue(lymphnode)silverstaining1reticularcell2reticularfiber3lymphocyte同步练习习一、填空空1.浆细细胞超微微结构特特点是，，细胞质质内含有有大量____________和____________,发发达的的_______________。。2．巨噬噬细胞的的功能主主要是_____________、_______________和和____________。粗面内质质网游离核糖糖体高尔基复复合体吞噬作用用抗原提呈呈作用分泌功能能同步练习习一、填空空3．成纤纤维细胞胞具有产产生_______和和________的的功能。。当成纤纤维细胞胞功能处处于静止止状态时称______细细胞。4.肥肥大细胞胞释放的的_________和_________可使细支支气管平平滑肌收收缩及毛毛细血管管扩张,________具具有抗凝凝血作用用。纤维纤维基质组胺白三烯肝素同步练习二、单项项选择1．巨噬细细胞的前身身是（））A.间充质质细胞B.网网状细胞C.内内皮细胞D.单单核细胞E.淋巴巴细胞2.疏松松结缔组织织中具有吞吞噬作用的的细胞是()A.成纤维维细胞B.巨巨噬细胞C.浆细胞D.肥肥大细胞E.脂肪肪细胞DB同步练习二、单项项选择3.关于于浆细胞的的描述，哪哪一项是错错误的()A.胞质嗜嗜碱性B.细细胞核常偏偏位C.核核旁有一浅浅染区D.参与细细胞免疫E.粗面面内质网丰丰富4．成纤维维细胞的电电镜结构特特点是()A.有大量量的溶酶体体B.有有大量的脂脂滴C.有有丰富的线线粒体D.有膜包包颗粒E.有丰富富的粗面内内质网、游游离核糖体体和发达的高尔基基复合体DE同步练习三、判断1. 成纤纤维细胞和和纤维细胞胞是处于不不同功能状状态的同一一种细胞，，能相互转转化。2. 结缔缔组织中的的成纤维细细胞和网状状细胞均可可产生纤维维。浆细胞的功功能是合成成和分泌免免疫球蛋白白(抗体)。4．浆细胞胞卵圆形,核圆偏偏居细胞一一侧,胞胞质嗜酸性性,电镜下下可见大量量平行排列列的粗面内内质网和发发达的高尔尔基复合体体。正确正确正确错误9、静夜四无邻邻，荒居旧业业贫。。12月-2212月-22Tuesday,December20,202210、雨中黄叶叶树，灯下下白头人。。。17:06:4217:06:4217:0612/20/20225:06:42PM11、以我我独沈沈久，，愧君君相见见频。。。12月月-2217:06:4217:06Dec-2220-Dec-2212、故人江海海别，几度度隔山川。。。17:06:4217:06:4217:06Tuesday,December20,202213、乍见翻疑疑梦，相悲悲各问年。。。12月-2212月-2217:06:4217:06:42December20,202214、他乡生生白发，，旧国见见青山。。。20十十二月20225:06:42下午午17:06:4212月-2215、比不不了得得就不不比，，得不不到的的就不不要。。。。。十二月月225:06下下午午12月月-2217:06December20,202216、行动动出成成果，，工作作出财财富。。。2022/12/2017:06:4217:06:4220December202217、做前前，能能够环环视四四周；；做时时，你你只能能或者者最好好沿着着以脚脚为起起点的的射线线向前前。。。5:06:42下下午5:06下下午午17:06:4212月月-229、没有有失败败，只只有暂暂时停停止成成功！！。12月月-2212月月-22Tuesday,December20,202210、很多多事情情努力力了未未必有有结果果，但但是不不努力力却什什么改改变也也没有有。。。17:06:4217:06:4217:0612/20/20225:06:42PM11、成成功功就就是是日日复复一一日日那那一一点点点点小小小小努努力力的的积积累累。。。。12月月-2217:06:4217:06Dec-2220-Dec-2212、世间间成事事，不不求其其绝对对圆满满，留留一份份不足足，可可得无无限完完美。。。17:06:4217:06:4217:06Tuesday,December20,202213、不知知香积积寺，，数里里入云云峰。。。12月月-2212月月-2217:06:4217:06:42December20,202214、意志坚坚强的人人能把世世界放在在手中像像泥块一一样任意意揉捏。。20十十二月20225:06:42下午午17:06:4212月-2215、楚塞三三湘接，，荆门九九派通。。。。十二月225:06下午午12