TAK-041-NBI-1065846-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemETAK-041Cat.No.:HY-132228CASNo.:1929519-13-0Synonyms:NBI-1065846分⼦式:C₁₈H₁₅F₃N₄O₃分⼦量:392.33作⽤靶点:GPR139作⽤通路:GPCR/GProtein;NeuronalSignaling储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:100mg/mL(254.89mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.5489mL12.7444mL25.4887mL5mM0.5098mL2.5489mL5.0977mL10mM0.2549mL1.2744mL2.5489mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>90%cornoil1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemESolubility:≥2.5mg/mL(6.37mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性TAK-041⼀种有效和选择性的GPR139激动剂，EC50为22nM。TAK-041具有研究精神分裂症性症状的潜⼒。体内研究TAK-041(0.03-3mg/kg;P.o.)improvessocialbehaviorinBALB/cmice[1].AnimalModel:BALB/cmice[1]Dosage:0.03,0.3,and3mg/kgAdministration:P.o.Result:Dose-dependentlyimprovedthesocialbehaviorofBALB/cmice.REFERENCES[1].ReichardHA,etal.DiscoveryofTAK-041:aPotentandSelectiveGPR139AgonistExploredfortheTreatmentofNegativeSymptomsAssociatedwithSchizophrenia[publishedonlineaheadofprint,2021Jul14].JMedChem.2021;10.1021/acs.jmedchem.1c00820.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-5895