Furafylline - Cytochrome P450 抑制剂 - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEFurafyllineCat. No.: HY-107204CAS No.: 80288-49-9分式: CHNO分量: 260.25作靶点: Cytochrome P450作通路: Metabolic Enzyme/Protease储存式: Powder -20C 3 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 12.5 mg/mL (48.03 mM; Need ultraso

2、nic)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.17 mg/mL (8.34 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.17 mg/mL (8.34 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE物活性 Furafylline种有效且有选择性的细胞素 P450IA2 抑制剂，其 IC50 值为 0.07 M。I

3、C50 & Target IC50: 0.07 M (human cytochrome P450IA2) 1体内研究 Furafylline is a potent and selective inhibitor of human cytochrome P450IA2 with an IC50 of 0.07 M inkinase experiment. Furafylline is a methylxanthine derivative that is introduced as a long-acting replacementfor theophylline in the treatme

4、nt of asthma. Administration of Furafylline is associated with an elevation inplasma levels of caffeine, due to inhibition of caffeine oxidation, a reaction catalysed by one or morehydrocarbon-inducible isoenzymes of P450. Furafylline has either very little or no effect on humanmonooxygenase activit

5、ies catalysed by other isoenzymes of P450, including P4501ID1, P4501IC, P450IIIA1.REFERENCES1. Sesardic D, et al. Furafylline is a potent and selective inhibitor of cytochrome P450IA2 in man. Br J Clin Pharmacol. 1990 Jun;29(6):651-63.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-58