Olopatadine-hydrochloride-ALO4943A-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEOlopatadine hydrochlorideCat. No.: HY-B0426ACAS No.: 140462-76-6Synonyms: ALO4943A; KW4679分式: CHClNO分量: 373.87作靶点: Histamine Receptor作通路: GPCR/G Protein; Immunology/Inflammation; NeuronalSignaling储存式: Powder -20C 3 years4C 2 yea

2、rsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 50 mg/mL (133.74 mM; Need ultrasonic)H2O : 6.67 mg/mL (17.84 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.6747 mL 13.3736 mL 26.7473 mL5 mM 0.5349 mL 2.6747 mL 5.3495 mL10 mM 0.2675 mL 1.3374 mL 2.6747 mL请根据产品在不同溶剂中的溶

3、解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (6.69 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD

4、in saline)1/2 Master of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.5 mg/mL (6.69 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (6.69 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Olopatadine 盐酸盐(ALO4943A)组胺受体阻断剂，可作于过敏性结膜炎。REFERENCES1. Tamura, T., et al., Effect of olo

5、patadine and other histamine H1 receptor antagonists on the skin inflammation induced by repeatedtopical application of oxazolone in mice. Pharmacology, 2005. 75(1): p. 45-52.2. Ohmori, K., et al., Pharmacological, pharmacokinetic and clinical properties of olopatadine hydrochloride, a new antialler

6、gic drug. Jpn JPharmacol, 2002. 88(4): p. 379-97.3. Yanni, J.M., et al., The in vitro and in vivo ocular pharmacology of olopatadine (AL-4943A), an effective anti-allergic/antihistaminic agent.J Ocul Pharmacol Ther, 1996. 12(4): p. 389-400.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-8