sn-Glycero-3-phosphocholine-Choline-Alfoscerate-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEsn-Glycero-3-phosphocholineCat. No.: HY-17552CAS No.: 28319-77-9Synonyms: Choline Alfoscerate; Alpha-GPC; L-GPC分式: CHNOP分量: 257.22作靶点: AChE; Endogenous Metabolite作通路: Neuronal Signaling; Metabolic Enzyme/Protease储存式: 4C, stored

2、under nitrogen* In solvent : -80C, 6 months; -20C, 1 month (stored undernitrogen)溶解性数据体外实验 H2O : 500 mg/mL (1943.86 mM; Need ultrasonic)DMSO : 125 mg/mL (485.97 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.8877 mL 19.4386 mL 38.8772 mL5 mM 0.7775 mL

3、 3.8877 mL 7.7754 mL10 mM 0.3888 mL 1.9439 mL 3.8877 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/

4、mL (8.09 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (8.09 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (8.09 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 sn-Glycero-3-phospho

5、choline (Choline Alfoscerate)脑磷脂物合成的前体，可提胆碱在神经组织中的物利度。sn-Glycero-3-phosphocholine (Choline Alfoscerate) 对认知功能有显著响，具有良好的安全性和耐受性，对阿尔茨海默病和痴呆症的治疗有效 1 2。IC50 & Target Human Endogenous Metabolite体内研究 Treatment with sn-Glycero-3-phosphocholine (Choline Alfoscerate) (250 mg/kg; i.m.; daily for 3 weeks) afte

6、rseizure can improve seizure-induced cognitive impairment 2.sn-Glycero-3-phosphocholine (Choline Alfoscerate) increases the release of acetylcholine in rathippocampus, facilitates learning and memory in experimental animals, improves brain transductionmechanisms and decreases age-dependent structura

7、l changes occurring in rat brain areas involved inlearning and memory 3.Animal Model: Sprague-Dawley male rats 2Dosage: 250 mg/kgAdministration: Intramuscular injection; starting at 3 weeks after seizure and continuing daily for 3 weeksResult: Improve seizure-induced cognitive impairment.REFERENCES1

8、. Traini E, et al. Choline alphoscerate (alpha-glyceryl-phosphoryl-choline) an old choline- containing phospholipidwith a still interestingprofile as cognition enhancing agent. Curr Alzheimer Res. 2013 Dec;10(10):1070-9.2. Lee SH, et al. Late treatment with choline alfoscerate (l-alpha glycerylphosp

9、horylcholine, -GPC) increases hippocampal neurogenesisand provides protection against seizure-induced neuronal death and cognitive impairment. Brain Res. 2017 Jan 1;1654(Pt A):66-76.3. Traini E, et al. Choline alphoscerate (alpha-glyceryl-phosphoryl-choline) an old choline- containing phospholipidwith a still interestingprofile as cognition enhancing agent. Curr Alzheimer Res. 2013 Dec;10(10):1070-9.McePdfHeightCaution: Product has not been fully validated for