AG1024-Tyrphostin-AG-1024-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEAG1024Cat. No.: HY-10253CAS No.: 65678-07-1Synonyms: Tyrphostin AG 1024分式: CHBrNO分量: 305.17作靶点: IGF-1R; Autophagy作通路: Protein Tyrosine Kinase/RTK; Autophagy储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解

2、性数据体外实验 DMSO : 50 mg/mL (163.84 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.2769 mL 16.3843 mL 32.7686 mL5 mM 0.6554 mL 3.2769 mL 6.5537 mL10 mM 0.3277 mL 1.6384 mL 3.2769 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前

3、请先配制澄的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (8.19 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 AG-1024 (Tyrphostin)能抑制IGF-1R

4、磷酸化，IC50为7 M，对IR的IC50则为57 M。户使本产品发表的科研献 Biomed Pharmacother. 2017 Nov;95:1346-1358.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Prrizas M, et al. Specific inhibition of insulin-like growth factor-1 and insulin receptor tyrosine kinase activity and biological function bytyrph

5、ostins. Endocrinology. 1997 Apr;138(4):1427-33.2. Wen B, et al. Tyrphostin AG 1024 modulates radiosensitivity in human breast cancer cells. Br J Cancer. 2001 Dec 14;85(12):2017-21.3. von Willebrand M, et al. The tyrphostin AG1024 accelerates the degradation of phosphorylated forms of retinoblastoma

6、protein (pRb)and restores pRb tumor suppressive function in melanoma cells. Cancer Res. 2003 Mar 15;63(6):1420-9.4. Deutsch E, et al. Tyrosine kinase inhibitor AG1024 exerts antileukaemic effects on STI571-resistant Bcr-Abl expressing cells anddecreases AKT phosphorylation. Br J Cancer. 2004 Nov 1;91(9):1735-41.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 4