Pseudoginsenoside-F11-Ginsenoside-A1-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEPseudoginsenoside F11Cat. No.: HY-N0541CAS No.: 69884-00-0Synonyms: Ginsenoside A1分式: CHO分量: 801.01作靶点: Others作通路: Others储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 100 mg/mL (124.84 mM

2、; Need ultrasonic)H2O : 0.67 mg/mL (0.84 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.2484 mL 6.2421 mL 12.4842 mL5 mM 0.2497 mL 1.2484 mL 2.4968 mL10 mM 0.1248 mL 0.6242 mL 1.2484 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加

3、助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.75 mg/mL (3.43 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.75 mg/mL (3.43 mM); Clear solution1/2 Master of Sma

4、ll Molecules 您边的抑制剂师www.MedChemE3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.75 mg/mL (3.43 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Pseudoginsenoside F11 (Ginsenoside A1)西洋参的组成成分，能够抵抗由莨菪碱、吗啡、脱氧黄碱诱导的学习记忆能缺失。体外研究 Biochemical experiments revealed that Pseudoginsenoside F11 (Ginsenoside A1) could

5、inhibit diprenorphine(DIP) binding with an IC50 of 6.1 M and reduced the binding potency of morphine in Chinese hamster ovary(CHO)- cells 1.体内研究 One in vivo model of cisplatin-induced acute renal failure was performed. The results showed thatpretreatment with Pseudoginsenoside Pseudoginsenoside F11

6、(Ginsenoside A1) reduced cisplatin-elevatedblood urea nitrogen and creatinine levels, as well as ameliorated the histophathological damage 1. Wetested the effects of Pseudoginsenoside Pseudoginsenoside F11 (Ginsenoside A1) on morphine-induceddevelopment of behavioral sensitization and alterations in

7、 glutamate levels in the medial prefrontal cortex(mPFC) in freely moving mice by using in vivo microdialysis. As the results shown, PseudoginsenosidePseudoginsenoside F11 (Ginsenoside A1) antagonized the development of behavioral sensitization anddecrease of glutamate in the mPFC induced by morphine

8、 3.REFERENCES1. Wang H, et al. The pseudoginsenoside F11 ameliorates cisplatin-induced nephrotoxicity without compromising its anti-tumor activity invivo. Scientific Reports 2014, 4:49862. Li Zhu, et al. Pseudoginsenoside-F11 attenuates morphine-induced signalling in Chinese hamster ovary- cells. Ne

9、uroreport, 25 May2001 - Volume 12 - Issue 7 - pp 1453-14563. Yue Hao, et al. Pseudoginsenoside-F11 decreases morphine-induced behavioral sensitization and extracellular glutamate levels in themedial prefrontal cortex in mice. Pharmacology Biochemistry and BehaviorVolume 86, Issue 4, April 2007, Pages 660666McePdfHeightCaution: Product has not been fully validated for medi