K-7174-dihydrochloride-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEK-7174 dihydrochlorideCat. No.: HY-12743ACAS No.: 191089-60-8分式: CHClNO分量: 641.67作靶点: Others作通路: Others储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 H2O : 15 mg/mL (23.38 mM; Need ultrasonic and

2、 warming)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.5584 mL 7.7922 mL 15.5843 mL5 mM 0.3117 mL 1.5584 mL 3.1169 mL10 mM 0.1558 mL 0.7792 mL 1.5584 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 K-7174盐酸盐是细胞粘附抑制剂，能抑制VCAM-1的表达量。REFERENCES1. Umetani M, et al. A novel cel

3、l adhesion inhibitor, K-7174, reduces the endothelial VCAM-1 induction by inflammatory cytokines, actingthrough the regulation of GATA. Biochem Biophys Res Commun. 2000 Jun 7;272(2):370-4.2. Imagawa S, et al. A GATA-specific inhibitor (K-7174) rescues anemia induced by IL-1beta, TNF-alpha, or L-NMMA

4、. FASEB J. 20031/2 Master of Small Molecules 您边的抑制剂师www.MedChemESep;17(12):1742-4.3. Shimada T, et al. Unexpected blockade of adipocyte differentiation by K-7174: implication for endoplasmic reticulum stress. BiochemBiophys Res Commun. 2007 Nov 16;363(2):355-60.4. Kikuchi J, et al. The novel orally

5、active proteasome inhibitor K-7174 exerts anti-myeloma activity in vitro and in vivo by down-regulatingthe expression of class I histone deacetylases. J Biol Chem. 2013 Aug 30;288(35):25593-602.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-5895