CCMI - α7 nAChR PAM - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemECCMICat. No.: HY-12150CAS No.: 917837-54-8分式: CHClNO分量: 388.25作靶点: nAChR作通路: Membrane Transporter/Ion Channel; Neuronal Signaling储存式: -20C, sealed storage, away from moisture* In solvent : -80C, 6 months; -20C, 1 month (sealedst

2、orage, away from moisture)溶解性数据体外实验 DMSO : 100 mg/mL (257.57 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.5757 mL 12.8783 mL 25.7566 mL5 mM 0.5151 mL 2.5757 mL 5.1513 mL10 mM 0.2576 mL 1.2878 mL 2.5757 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶

3、解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 0.83 mg/mL (2.14 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 0.83 mg/mL (2.14 mM); Clear solutionBIOLOGICA

4、L ACTIVITY1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE物活性 CCMI种有效、选择性的 7 nAChR 正向别构调节剂，不是通过正性结合位点与 7 nAChR 结合并使其激活，能有效正向调节 7 nAChR 上激动剂诱导的电流。CCMI 在神经系统认知功能紊乱疾病中具有潜在疗效1。IC50 & Target 7 nAChR 1体外研究 CCMI (Compound 6) is a potent and selective 7 nAChR-positive allosteric modulator, does not bind to

5、 oractivate 7 nAChRs via the orthosteric site, and causes significant positive modulation of agonist-inducedcurrents at 7 nAChRs 1.REFERENCES1. Ng HJ, et al. Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators. Proc Natl Acad Sci U SA. 2007 May 8;104(19):8059-64. Epub 2007 Apr 30.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 02