Oroxylin-A-Baicalein-6-methyl-ether-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEOroxylin ACat. No.: HY-N0560CAS No.: 480-11-5Synonyms: Baicalein 6-methyl ether; 6-Methoxybaicalein分式: CHO分量: 284.26作靶点: HIF/HIF Prolyl-Hydroxylase; Autophagy作通路: Metabolic Enzyme/Protease; Autophagy储存式: Powder -20C 3 years4C 2

2、yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 32 mg/mL (112.57 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.5179 mL 17.5895 mL 35.1791 mL5 mM 0.7036 mL 3.5179 mL 7.0358 mL10 mM 0.3518 mL 1.7590 mL 3.5179 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请

3、注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (7.32 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL AC

4、TIVITY物活性 千层纸素 (Oroxylin A)种有活性的 酮类化合物，具有较强的抗癌作。户使本产品发表的科研献 Cancers (Basel). 2019 Mar 12;11(3). pii: E353.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Zhao K, et al. Oroxylin A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation

5、tostabilize p53 and inhibit glycolysis in wt-p53 cancer cells. J Hematol Oncol. 2015 Apr 23;8:41./pubmed/259029142. Dai Q, et al. Oroxylin A regulates glucose metabolism in response to hypoxic stress with the involvement of Hypoxia-inducible factor-1 inhuman hepatoma HepG2 cells. Mol Carcinog. 2015

6、Aug 10.3. Wei L, et al. Oroxylin A inhibits glycolysis-dependent proliferation of human breast cancer via promoting SIRT3-mediated SOD2transcription and HIF1 destabilization. Cell Death Dis. 2015 Apr 9McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820