Esomeprazole-magnesium-S-Omeprazole-magnesium-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEEsomeprazole magnesiumCat. No.: HY-B1446CAS No.: 161973-10-0Synonyms: (S)-Omeprazole magnesium; (-)-Omeprazole magnesium分式: CHMgNOS分量: 713.12作靶点: Proton Pump作通路: Membrane Transporter/Ion Channel储存式: Powder -20C 3 years4C 2 years

2、In solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 125 mg/mL (175.29 mM)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (2.92 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)1/2 Master of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.08 mg/mL (2.92 mM); Clear s

3、olution3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (2.92 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Esomeprazole magnesium种 H+, K+-ATPase 抑制剂，能够有效于上肠道疾病的研究。IC50 & Target H+, K+-ATPase 1体外研究 Esomeprazole magnesium is an inhibitor of H+, K+-ATPase 1.体内研究 Esomeprazole magnesium (0.5, 5, 50

4、 mg/kg/day, p.o.) produces increased gastric total antioxidant capacity,decreases gastric lipid peroxide levels, significantly increases superoxide dismutase levels, but shows noobvious effect on colonic lipid peroxide levels in mice 1.PROTOCOLAnimal Mice 1Administration 1 In this 10-day supplementa

5、tion experiment, mice (n = 10/group) receive the following: 1) as a control group,only the vehicle for dissolution of Esomeprazole (PEG-400) given orally once daily by gastric gavage; 2)Esomeprazole 0.5 mg/kg in an equivalent volume of PEG-400 given orally once daily by gastric lavage; 3)Esomeprazol

6、e 5 mg/kg in an equivalent volume of PEG-400 given orally once daily by gastric lavage; and 4)Esomeprazole 50 mg/kg in an equivalent volume of PEG-400 given orally once daily by gastric lavage 1.MCE has not independently confirmed the accuracy of these methods. They are for reference only.REFERENCES1. Koch TR, et al. Effect of the H, K-ATPase inhibitor, esomeprazole magnesium, on gut total antioxidant capacity in mice. J Nutr Biochem.2004 Sep;15(9):522-6.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only