Mosapride-citrate-TAK-370-citrate-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEMosapride citrateCat. No.: HY-B0189ACAS No.: 112885-42-4Synonyms: TAK-370 citrate; AS-4370 citrate分式: CHClFNO分量: 614.02作靶点: 5-HT Receptor作通路: GPCR/G Protein; Neuronal Signaling储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6

2、months-20C 1 month溶解性数据体外实验 DMSO : 100 mg/mL (162.86 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.6286 mL 8.1431 mL 16.2861 mL5 mM 0.3257 mL 1.6286 mL 3.2572 mL10 mM 0.1629 mL 0.8143 mL 1.6286 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制

3、澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (4.07 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (4.07 mM); Clear solution3. 请依序添

4、加每种溶剂： 10% DMSO 90% corn oil1/2 Master of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.5 mg/mL (4.07 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Mosapride柠檬酸盐促胃肠动化合物，是5HT4激动剂。REFERENCES1. Tack J, et al. Systematic review: cardiovascular safety profile of 5-HT(4) agonists developed for gastrointest

5、inal disorders. AlimentPharmacol Ther. 2012 Apr;35(7):745-67.2. Curran MP, et al. Mosapride in gastrointestinal disorders. Drugs. 2008;68(7):981-91.3. Odaka T, et al. Serotonin 5- HT4 receptor agonist (mosapride citrate). Nihon Rinsho. 2006 Aug;64(8):1491-4.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-5