Calcium-Channel-Inhibitors-Modulators-MCE

1、 HYPERLINK https:/www.MedChemE/Targets/Calcium Channel.html Calcium HYPERLINK https:/www.MedChemE/Targets/Calcium Channel.html HYPERLINK https:/www.MedChemE/Targets/Calcium Channel.html ChannelCa2+ channels; Ca channelsCalcium channel is an ion channel which displays selective permeability to calciu

2、m ions. It is sometimes synonymous asvoltage-dependent calcium channel, although there are also ligand-gated calcium channels. Voltage-gated calcium (CaV) channelscatalyse rapid, highly selective influx of Ca2+ into cells despite a 70-fold higher extracellular concentration of Na+. Some calciumchann

3、el blockers have the added benefit of slowing your heart rate, which can further reduce blood pressure, relieve chest pain(angina) and control an irregular heartbeat.www.MedChemE 1 HYPERLINK https:/www.MedChemE/Targets/Calcium Channel.html Calcium HYPERLINK https:/www.MedChemE/Targets/Calcium Channe

4、l.html HYPERLINK https:/www.MedChemE/Targets/Calcium Channel.html Channel HYPERLINK https:/www.MedChemE/Targets/Calcium Channel.html HYPERLINK https:/www.MedChemE/Targets/Calcium Channel.html Inhibitors, HYPERLINK https:/www.MedChemE/Targets/Calcium Channel.html HYPERLINK https:/www.MedChemE/Targets

5、/Calcium Channel.html Antagonists, HYPERLINK https:/www.MedChemE/Targets/Calcium Channel.html HYPERLINK https:/www.MedChemE/Targets/Calcium Channel.html Activators, HYPERLINK https:/www.MedChemE/Targets/Calcium Channel.html HYPERLINK https:/www.MedChemE/Targets/Calcium Channel.html Agonists HYPERLIN

6、K https:/www.MedChemE/Targets/Calcium Channel.html HYPERLINK https:/www.MedChemE/Targets/Calcium Channel.html & HYPERLINK https:/www.MedChemE/Targets/Calcium Channel.html HYPERLINK https:/www.MedChemE/Targets/Calcium Channel.html Modulators HYPERLINK https:/www.MedChemE/_addition_-Kavain.html (+)-Ka

7、vainCat. No.: HY-B1671 HYPERLINK https:/www.MedChemE/minus-denudatin-b.html (-)-Denudatin HYPERLINK https:/www.MedChemE/minus-denudatin-b.html HYPERLINK https:/www.MedChemE/minus-denudatin-b.html B(Denudatin B) Cat. No.: HY-N3729(+)-Kavain, a main kavalactone extracted from Pipermethysticum, has ant

8、iconvulsive properties,attenuating vascular smooth muscle contractionthrough interactions with voltage-dependent Na+and Ca2+ channels.(-)-Denudatin B is an antiplatelet agent.(-)-Denudatin B relaxed vascular smooth muscle byinhibiting the Ca2+ influx through voltage-gatedand receptor-operated Ca2+ c

9、hannels. And(-)-Denudatin B has nonspecific antiplateletaction.Purity: 99.98%Clinical Data: LaunchedSize: 10 mM 1 mL, 5 mg, 10 mgPurity: 97.0%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/2r-s-6-png.html (2R/S)-6-PNG(6-Prenylnaringenin) Cat. No.: HY-115681 HYPE

10、RLINK https:/www.MedChemE/Bay-K-8644-_R_-_addition_-.html (R)-(+)-Bay-K-8644Cat. No.: HY-15125(2R/S)-6-PNG (6-Prenylnaringenin) is a potent andreversible Ca 3.2 T-type Ca2+ channelsv(T-channels) blocker. (2R/S)-6-PNG can penetratethe blood-brain barrier (BBB). (2R/S)-6-PNGsuppresses neuropathic and

11、visceral pain in mice.(R)-(+)-Bay-K-8644 is a calcium channelinhibitor. (R)-(+)-Bay-K-8644 inhibits Ba2+currents (I ) ( =975 nM).Ba IC50Purity: 99.0%Clinical Data: Phase 1Size: 5 mgPurity: 99.69%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg HYPERLINK https

12、:/www.MedChemE/s-minus-felodipine-d5.html (R)-(-)-Felodipine-d5 HYPERLINK https:/www.MedChemE/s-minus-felodipine-d5.html HYPERLINK https:/www.MedChemE/r-lercanidipine-hydrochloride.html (R)-Lercanidipine HYPERLINK https:/www.MedChemE/r-lercanidipine-hydrochloride.html HYPERLINK https:/www.MedChemE/r

13、-lercanidipine-hydrochloride.html hydrochlorideCat. No.: HY-132670S Cat. No.: HY-B0612D(R)-(-)-Felodipine-d5 is the deuterium labeled(R)-(-)-Felodipine. (R)-(-)-Felodipine is the Senantiomer of Felodipine. Felodipine, adihydropyridine, is a potent, vasoselectivecalcium channel antagonist.(R)-Lercani

14、dipine hydrochloride is theR-enantiomer of Lercanidipine. (R)-lercanidipinehydrochloride is a calcium channel blocker.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/r-lercanidipin

15、e-d3-hydrochloride.html (R)-Lercanidipine-d3 HYPERLINK https:/www.MedChemE/r-lercanidipine-d3-hydrochloride.html HYPERLINK https:/www.MedChemE/r-lercanidipine-d3-hydrochloride.html hydrochloride HYPERLINK https:/www.MedChemE/r-lercanidipine-d3-hydrochloride.html HYPERLINK https:/www.MedChemE/rac-mem

16、-1003.html (Rac)-MEM HYPERLINK https:/www.MedChemE/rac-mem-1003.html HYPERLINK https:/www.MedChemE/rac-mem-1003.html 1003Cat. No.: HY-B0612DS Cat. No.: HY-121604(R)-lercanidipine D3 (hydrochloride) is adeuterium labeled (R)-Lercanidipine hydrochloride.(R)-Lercanidipine D3 (hydrochloride), theR-enant

17、iomer of Lercanidipine, is a calciumchannel blocker.(Rac)-MEM 1003 is the racemate of MEM 1003. MEM1003, a dihydropyridine compound, is a potentL-type Ca2+ channel antagonist and has thepotential for Alzheimers disease research.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity:

18、 99.52%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/Bay-K-8644-_S_-_-_-.html (S)-(-)-Bay-K-8644 HYPERLINK https:/www.MedChemE/Bay-K-8644-_S_-_-_-.html HYPERLINK https:/www.MedChemE/s-lercanidipine-hydrochloride.html (S)-Lerca

19、nidipine HYPERLINK https:/www.MedChemE/s-lercanidipine-hydrochloride.html HYPERLINK https:/www.MedChemE/s-lercanidipine-hydrochloride.html hydrochlorideCat. No.: HY-15124 Cat. No.: HY-B0612E(S)-(-)-Bay-K-8644 is an agonist of L-type Ca2+channel. (S)-(-)-Bay-K-8644 activates Ba2+currents (I ) ( =32 n

20、M).Ba EC50(S)-Lercanidipine hydrochloride is theS-enantiomer of Lercanidipine hydrochloride.(S)-lercanidipine hydrochloride is a potentcalcium channel blocker.Purity: 98.52%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 50 mgPurity: 98%Clinical Data: No Development ReportedSize

21、: 1 mg2 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMedChemE HYPERLINK https:/www.MedChemE/s-verapamil-d7-hydrochloride.html (S)-Verapamil HYPERLINK https:/www.MedChemE/s-verapamil-d7-hydrochloride.html HYPERLINK https:/www.MedChemE/s-verapamil-d7-hydrochloride.html D7 HYPERLINK https:/www.MedCh

22、emE/s-verapamil-d7-hydrochloride.html HYPERLINK https:/www.MedChemE/s-verapamil-d7-hydrochloride.html hydrochloride(S)-(-)-Verapamil D7 hydrochloride) Cat. No.: HY-135336AS HYPERLINK https:/www.MedChemE/s-verapamil-hydrochloride.html (S)-Verapamil HYPERLINK https:/www.MedChemE/s-verapamil-hydrochlor

23、ide.html HYPERLINK https:/www.MedChemE/s-verapamil-hydrochloride.html hydrochloride(S)-(-)-Verapamil hydrochloride) Cat. No.: HY-135336A(S)-Verapamil D7 hydrochloride (S)-(-)-VerapamilD7 hydrochloride) is a deuterium labeled(S)-Verapamil hydrochloride. (S)-Verapamilhydrochloride (S(-)-Verapamil hydr

24、ochloride)inhibits leukotriene C4 (LTC4) and calceintransport by MRP1.(S)-Verapamil hydrochloride (S(-)-Verapamilhydrochloride) inhibits leukotriene C4 (LTC4) andcalcein transport by MRP1. (S)-Verapamilhydrochloride leads to the death of potentiallyresistant tumor cells.Purity: 98%Clinical Data: No

25、Development ReportedSize: 1 mgPurity: 99.39%Clinical Data: LaunchedSize: 10 mM 1 mL, 5 mg, 10 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/s-s-verapamil-d6-hydrochloride.html (S)-Verapamil-d6 HYPERLINK https:/www.MedChemE/s-s-verapamil-d6-hydrochloride.html HYPERLINK https:/www.MedChemE/s-s-verap

26、amil-d6-hydrochloride.html hydrochloride(S)-(-)-Verapamil-d6 hydrochloride) Cat. No.: HY-135336AS1 HYPERLINK https:/www.MedChemE/praeruptorin-a-1.html ()-Praeruptorin HYPERLINK https:/www.MedChemE/praeruptorin-a-1.html HYPERLINK https:/www.MedChemE/praeruptorin-a-1.html ACat. No.: HY-N0081(S)-Verapa

27、mil-d6 (S)-(-)-Verapamil-d6)hydrochloride is the deuterium labeled(S)-Verapamil hydrochloride. (S)-Verapamilhydrochloride (S(-)-Verapamil hydrochloride)inhibits leukotriene C4 (LTC4) and calceintransport by MRP1.()-Praeruptorin A is the di-esterified product ofcis-khellactone (CKL) and the major act

28、iveingredient in Peucedani Radix which consists ofthe dried roots of PeucedanumpraeruptorumDunn (Apiaceae).Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 10 mgPurity: 99.31%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 20 mg HYPERLINK https:/www.MedChemE/1-2-4-trihydroxybenz

29、ene.html 1,2,4-TrihydroxybenzeneCat. No.: HY-W010451 HYPERLINK https:/www.MedChemE/1-octanol.html 1-Octanol(Octanol) Cat. No.: HY-W0320131,2,4-Trihydroxybenzene (Hydroxyhydroquinone), aby-product of coffee bean roasting, increasesintracellular Ca2+ concentration in rat thymiclymphocytes.1-Octanol (O

30、ctanol), a saturated fatty alcohol, isa T-type calcium channels (T-channels) inhibitorwith an IC of 4 M for native T-currents.501-Octanol is a highly attractive biofuel withdiesel-like properties.Purity: 99.12%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 500 mgPurity: 98.0%Clinical Data:

31、No Development ReportedSize: 10 mg HYPERLINK https:/www.MedChemE/14-deoxyandrographolide.html 14-Deoxyandrographolide HYPERLINK https:/www.MedChemE/14-deoxyandrographolide.html HYPERLINK https:/www.MedChemE/2-aminoethyl-diphenylborinate.html 2-Aminoethyl HYPERLINK https:/www.MedChemE/2-aminoethyl-di

32、phenylborinate.html HYPERLINK https:/www.MedChemE/2-aminoethyl-diphenylborinate.html diphenylborinateCat. No.: HY-N4323(2-APB) Cat. No.: HY-W00972414-Deoxyandrographolide is a labdane diterpenewith calcium channel blocking activity.14-Deoxyandrographolide desensitizes hepatocytesto TNF-mediated apop

33、tosis through the release ofTNFRSF1A release.2-Aminoethyl diphenylborinate (2-APB) is acell-permeable inhibitor of IP3R. 2-Aminoethyldiphenylborinate also inhibits the store-operatedCa2+ (SOC) channel and activates some TRPchannels (V1, V2 and V3).Purity: 98.30%Clinical Data: No Development Reported

34、Size: 5 mg, 10 mgPurity: 98.36%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg HYPERLINK https:/www.MedChemE/2-aminoethyl-diphenylborinate-d10.html 2-Aminoethyl HYPERLINK https:/www.MedChemE/2-aminoethyl-diphenylborinate-d10.html HYPERLINK https:/www.MedChemE/2-aminoethyl-diphenylborina

35、te-d10.html diphenylborinate-d10 HYPERLINK https:/www.MedChemE/2-aminoethyl-diphenylborinate-d10.html HYPERLINK https:/www.MedChemE/4-bromo-a23187.html 4-Bromo HYPERLINK https:/www.MedChemE/4-bromo-a23187.html HYPERLINK https:/www.MedChemE/4-bromo-a23187.html A23187(2-APB-d10) Cat. No.: HY-W009724SC

36、at. No.: HY-N66942-Aminoethyl diphenylborinate-d10 (2-APB-d10) isthe deuterium labeled 2-Aminoethyldiphenylborinate. 2-Aminoethyl diphenylborinate(2-APB) is a cell-permeable inhibitor of IP3R.4-Bromo A23187 is a halogenated analog of thehighly selective calcium ionophore A-23187.4-Bromo A23187a calc

37、ium modulator, inducesapoptosis in different cells, including HL-60cells.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 99.0%Clinical Data: No Development ReportedSize: 1 mgwww.MedChemE 3 HYPERLINK https:/www.MedChemE/8-bromo-cgmp-sodium.html 8-Bromo-cGMP HYPERLINK https:/w

38、ww.MedChemE/8-bromo-cgmp-sodium.html HYPERLINK https:/www.MedChemE/8-bromo-cgmp-sodium.html sodium HYPERLINK https:/www.MedChemE/8-bromo-cgmp-sodium.html HYPERLINK https:/www.MedChemE/ABT-639.html ABT-639Cat. No.: HY-101379A Cat. No.: HY-197218-Bromo-cGMP sodium, a membrane-permeable analogueof cGMP

39、, is a PKG (protein kinase G) activator.8-Bromo-cGMP sodium significantly inhibits Ca2+macroscopic currents and impairs insulin releasestimulated with high K+.ABT-639 is a novel, peripherally acting, selectiveT-type Ca2+ channel blocker.Purity: 99.07%Clinical Data: No Development ReportedSize: 10 mM

40、 1 mL, 5 mg, 10 mgPurity: 98.86%Clinical Data: Phase 2Size: 10 mM 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/ABT-639_(hydrochloride).html ABT-639 HYPERLINK https:/www.MedChemE/ABT-639_(hydrochloride).html HYPERLINK https:/www.MedChemE/ABT-639_(hydrochloride).html hydrochlo

41、rideCat. No.: HY-101616 HYPERLINK https:/www.MedChemE/Acetylcholine-chloride.html Acetylcholine HYPERLINK https:/www.MedChemE/Acetylcholine-chloride.html HYPERLINK https:/www.MedChemE/Acetylcholine-chloride.html chloride(ACh chloride) Cat. No.: HY-B0282ABT-639 hydrochloride is a novel, peripherallya

42、cting, selective T-type Ca2+ channel blocker.Acetylcholine chloride (ACh chloride), aneurotransmitter, is a potent cholinergic agonist.Acetylcholine chloride is a modulator of theactivity of dopaminergic (DAergic) neurons throughthe stimulation of nicotinic acetylcholinereceptors (nAChRs).Purity: 98

43、%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98.0%Clinical Data: LaunchedSize: 10 mM 1 mL, 500 mg, 1 g, 5 g HYPERLINK https:/www.MedChemE/acetylcholine-d4-chloride.html Acetylcholine-d4 HYPERLINK https:/www.MedChemE/acetylcholine-d4-chloride.html HYPERLINK https:/www.MedChemE/acety

44、lcholine-d4-chloride.html chloride(ACh-d4 chloride) Cat. No.: HY-B0282S HYPERLINK https:/www.MedChemE/acetylcholine-d9-chloride.html Acetylcholine-d9 HYPERLINK https:/www.MedChemE/acetylcholine-d9-chloride.html HYPERLINK https:/www.MedChemE/acetylcholine-d9-chloride.html chloride(ACh-d9 chloride) Ca

45、t. No.: HY-B0282S1Acetylcholine-d9 (ACh-d9) chloride is thedeuterium labeled Acetylcholine chloride.Acetylcholine chloride (ACh chloride), aneurotransmitter, is a potent cholinergic agonist.Acetylcholine-d9 (ACh-d9) chloride is thedeuterium labeled Acetylcholine chloride.Acetylcholine chloride (ACh

46、chloride), aneurotransmitter, is a potent cholinergic agonist.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mg, 25 mg, 50 mgPurity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mg, 50 mg HYPERLINK https:/www.MedChemE/ACT-709478.html ACT-709478 HYPERLINK http

47、s:/www.MedChemE/ACT-709478.html HYPERLINK https:/www.MedChemE/Watanipidine_monohydrochloride.html AE0047 HYPERLINK https:/www.MedChemE/Watanipidine_monohydrochloride.html HYPERLINK https:/www.MedChemE/Watanipidine_monohydrochloride.html HydrochlorideCat. No.: HY-112723 Cat. No.: HY-U00284ACT-709478

48、is a potent, selective, orally active,and brain penetrating T-type calcium channelblocker. ACT-709478 is used in the research ofgeneralized epilepsies.AE0047 Hydrochloride is a calcium blocker, usedin the research of hypertensive disease.Purity: 99.59%Clinical Data: No Development ReportedSize: 5 mg

49、, 10 mg, 50 mg, 100 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/Amlodipine.html Amlodipine HYPERLINK https:/www.MedChemE/Amlodipine.html HYPERLINK https:/www.MedChemE/Amlodipine-besylate.html Amlodipine HYPERLINK https:/www.MedChemE/Amlodipine-be

50、sylate.html HYPERLINK https:/www.MedChemE/Amlodipine-besylate.html besylateCat. No.: HY-B0317(Amlodipine benzenesulfonate) Cat. No.: HY-B0317BAmlodipine, an antianginal agent and an orallyactive dihydropyridine calcium channel blocker,works by blocking the voltage-dependent L-typecalcium channels, t

51、hereby inhibiting the initialinflux of calcium. Amlodipine can be used for theresearch of high blood pressure and cancer.Amlodipine besylate (Amlodipine benzenesulfonate),an antianginal agent and an orally activedihydropyridine calcium channel blocker, works byblocking the voltage-dependent L-type c

52、alciumchannels, thereby inhibiting the initial influx ofcalcium.Purity: 99.76%Clinical Data: LaunchedSize: 10 mM 1 mL, 500 mg, 1 g, 5 gPurity: 99.92%Clinical Data: LaunchedSize: 10 mM 1 mL, 500 mg, 1 g, 5 g4 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMedChemE HYPERLINK https:/www.MedChemE/Amlod

53、ipine-maleate.html Amlodipine HYPERLINK https:/www.MedChemE/Amlodipine-maleate.html HYPERLINK https:/www.MedChemE/Amlodipine-maleate.html maleate HYPERLINK https:/www.MedChemE/Amlodipine-maleate.html HYPERLINK https:/www.MedChemE/amlodipine-d4-maleate-racemic.html Amlodipine-1,1,2,2-d4 HYPERLINK htt

54、ps:/www.MedChemE/amlodipine-d4-maleate-racemic.html HYPERLINK https:/www.MedChemE/amlodipine-d4-maleate-racemic.html maleateCat. No.: HY-B0317A Cat. No.: HY-B0317SAmlodipine maleate is a dihydropyridine calciumchannel blocker, acts as an orally activeantianginal agent. Amlodipine maleate blocks thev

55、oltage-dependent L-type calcium channels, therebyinhibiting the initial influx of calcium.Amlodipine-1,1,2,2-d4 maleate is the deuteriumlabeled Amlodipine.Purity: 99.85%Clinical Data: LaunchedSize: 10 mM 1 mL, 500 mg, 1 g, 5 gPurity: 98%Clinical Data: No Development ReportedSize: 5 mg, 25 mg, 50 mg

56、HYPERLINK https:/www.MedChemE/amlodipine-d4-besylate.html Amlodipine-d4 HYPERLINK https:/www.MedChemE/amlodipine-d4-besylate.html HYPERLINK https:/www.MedChemE/amlodipine-d4-besylate.html besylate(Amlodipine benzenesulfonate-d4 besylate) Cat. No.: HY-B0317BS HYPERLINK https:/www.MedChemE/amlodipine-

57、d4-maleate.html Amlodipine-d4 HYPERLINK https:/www.MedChemE/amlodipine-d4-maleate.html HYPERLINK https:/www.MedChemE/amlodipine-d4-maleate.html maleateCat. No.: HY-B0317ASAmlodipine-d4 (Amlodipine (benzenesulfonate)-d4)besylate is the deuterium labeled Amlodipinebesylate.Amlodipine-d4 maleate is the

58、 deuterium labeledAmlodipine maleate. Amlodipine maleate is adihydropyridine calcium channel blocker, acts asan orally active antianginal agent.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedC

59、hemE/Anipamil.html Anipamil HYPERLINK https:/www.MedChemE/Anipamil.html HYPERLINK https:/www.MedChemE/annonacin.html AnnonacinCat. No.: HY-U00044 Cat. No.: HY-N2877Anipamil is a long-acting calcium channelblocker, used for the treatment of cardiovasculardisease.Annonacin is an Acetogenin and promote

60、scytotoxicity via a pathway inhibiting themitochondrial complex. Annonacin is the activeagent found in Graviola leaf extract to act as aninhibitor of sodium/potassium (NKA) andsarcoplasmic reticulum (SERCA) ATPase pumps.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 97.0%Cl