LUF6000 - Adenosine Receptor Agonist - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemELUF6000Cat. No.: HY-13236CAS No.: 890087-21-5分式: CHClN分量: 411.33作靶点: Adenosine Receptor作通路: GPCR/G Protein储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 14.29 mg/mL (34.74 mM; Need ultraso

2、nic)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 1.43 mg/mL (3.48 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 1.43 mg/mL (3.48 mM); Suspended solution; Need ultrasonic3. 请依序添加每种溶剂： 10% DMSO 90% corn oil1/2 Master of Small Molecules 您边的抑制剂师www.MedChemESolubil

3、ity: 1.43 mg/mL (3.48 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 LUF6000A3腺苷受体变构调节剂。户使本产品发表的科研献 Mediators Inflamm. 2014;2014:708746.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Gao ZG, Verzijl D, Zweemer A et al. Functionally biased modulation of A(3) adenosine receptor agoni

4、st efficacy and potency byimidazoquinolinamine allosteric enhancers. Biochem Pharmacol. 2011 Sep 15;82(6):658-68. doi: 10.1016/j.bcp.2011.06.017.2. Szentmiklsi AJ, Cseppento A, Harmati G, Nnsi PP. Novel trends in the treatment of cardiovascular disorders: site- and event-selective adenosinergic drug

5、s. Curr Med Chem. 2011;18(8):1164-87.3. Heitman LH, G?bly?s A, Zweemer AM, et al. A series of 2,4-disubstituted quinolines as a new class of allosteric enhancers of theadenosine A3 receptor. J Med Chem. 2009 Feb 26;52(4):926-31.4. Gao ZG, Ye K, G?bly?s A, et al. Flexible modulation of agonist effica

6、cy at the human A3 adenosine receptor by the imidazoquinolineallosteric enhancer LUF6000. BMC Pharmacol. 2008 Dec 12;8:20.5. G?bly?s A, Gao ZG, Brussee J, et al. Structure-activity relationships of new 1H-imidazo4,5-cquinolin-4-amine derivatives as allostericenhancers of the A3 adenosine receptor. J Med Chem. 2006 Jun 1;49(11):3354-61.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: