Cobimetinib-R-enantiomer-GDC-0973-R-enantiomer-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemECobimetinib R-enantiomerCat. No.: HY-13079CAS No.: 934660-94-3Synonyms: GDC-0973 R-enantiomer; XL-518 R-enantiomer分式: CHFINO分量: 531.31作靶点: MEK作通路: MAPK/ERK Pathway储存式: Please store the product under the recommended conditions in

2、the COA.溶解性数据体外实验 DMSO : 100 mg/mL (188.21 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.8821 mL 9.4107 mL 18.8214 mL5 mM 0.3764 mL 1.8821 mL 3.7643 mL10 mM 0.1882 mL 0.9411 mL 1.8821 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择

3、适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.75 mg/mL (5.18 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.75 mg/mL (5.18 mM); Clear

4、 solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.75 mg/mL (5.18 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 Cobimetinib R-enantiomerCobimetinib 的低活性 R 型对映体。Cobimetinib 种有效的选择性 MEK 抑制剂。REFERENCES1. Hoeflich KP, et al. Intermittent administration of MEK inhibitor GDC-0973 plus PI3K inhibitor GDC-0941 triggers robust apoptosis andtumor growth inhibition. Cancer Res. 2012 Jan 1;72(1):210-9.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;/p>