Synta66 _CRAC Channel 抑制剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemESynta66Cat. No.: HY-111325CAS No.: 835904-51-3分式: CHFNO分量: 352.36作靶点: CRAC Channel作通路: Membrane Transporter/Ion Channel储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 77.5 mg/mL (219.95 mM;

2、 Need ultrasonic)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.58 mg/mL (7.32 mM); Suspended solution; Need ultrasonic and warming2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.58 mg/mL (7.32 mM); Suspended solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oil1/2 Master of Small Molecul

3、es 您边的抑制剂师www.MedChemESolubility: 2.58 mg/mL (7.32 mM); Clear solution; Need warmingBIOLOGICAL ACTIVITY物活性 Synta66钙离通道 Orai (CRAC 的核) 的抑制剂，主 于神经疾病的研究。IC50 & Target Orai 1体外研究 Synta66 is an inhibitor of Orai, which forms the pore of the CRAC channel. Synta66 (10 M) attenuates peakSOCE in Mller glia.

4、Synta66 (10 M) prevents orai channels mediating the residual SOC current in Trpc1/Mller cells 1. Synta66 (10 M) nearly completely blocks the Ca2+ entry signal evoked by CaCl2 addition,whereas it moderately reduces Ca2+ mobilization from stores with 10% to 30% in platelet. Synta66 (10 M)suppresses hu

5、man platelet activation in plasma and whole-blood thrombus formation. Synta66 (10 M) alsoinhibits murine platelet responses and thrombus formation 2. Synta66 (10 M) inhibits LAD2 human mastcell line. Synta66 (10 M) significantly inhibits FcRI stimulated histamine and TNF secretion, and hasdifferenti

6、al effects on FcRI stimulated prostaglandin D2 and cytokine release in human lung mast cells(HLMCs) 3.PROTOCOLCell Assay 3 Human Lung Mast Cell (HLMCs) are cultured in DMEM+Glutamax media containing 1% antibiotic-antimycotic solution, 1% non-essential amino acids, 10% fetal calf serum and supplement

7、ed with 100 ng/mLhuman stem cell factor, 50 ng/mL IL-6 and 10 ng/mL IL-10. For histamine assays mast cells are isolated fromhuman lung tissue and used within 24 h 3.MCE has not independently confirmed the accuracy of these methods. They are for reference only.户使本产品发表的科研献 Science in Dentistry, Univer

8、sity of Pennsylvania. 2019 Jun.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Molnr T, et al. Store-Operated Calcium Entry in Mller Glia Is Controlled by Synergistic Activation of TRPC and Orai Channels. JNeurosci. 2016 Mar 16;36(11):3184-98.2. van Kruchten R, et al. Antithrom

9、botic potential of blockers of store-operated calcium channels in platelets. Arterioscler Thromb VascBiol. 2012 Jul;32(7):1717-23.3. Wajdner HE, et al. Orai and TRPC channel characterization in FcRI-mediated calcium signaling and mediator secretion in human mastcells. Physiol Rep. 2017 Mar;5(5).McePdfHeight2/2 Master of Small Molecules 您边的抑制剂师www.MedChemECaution: Product has not been fully validated for med