Oxindole-Indolin-2-one-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEOxindoleCat. No.: HY-Y0061CAS No.: 59-48-3Synonyms: Indolin-2-one分式: CHNO分量: 133.15作靶点: Others作通路: Others储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 100 mg/mL (751.03 mM; Need ultrasoni

2、c)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 7.5103 mL 37.5516 mL 75.1033 mL5 mM 1.5021 mL 7.5103 mL 15.0207 mL10 mM 0.7510 mL 3.7552 mL 7.5103 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下

3、溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (18.78 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (18.78 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oil1/2 Master of Small Molecules 您边的抑制剂师ww

4、w.MedChemESolubility: 2.5 mg/mL (18.78 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Oxindole (Indolin-2-one)芳族杂环砌块。 Oxindole衍物已成为激酶抑制剂研究中的主要化合物。体外研究 Oxindole (Indolin-2-one) is a bicyclic structure consisting of a benzene ring fused to 2-pyrrolidone.Substituted indolinones can be referred as privileged

5、 structures owing to their excellent binding affinity formany receptors and to the number of approved drugs containing this scaffold 1. Oxindole has been found intissues and fluids of mammals as well as natural products produced by a range of plants, bacteria andinvertebrates. 2-indolinone derivativ

6、es possess diverse range of pharmacological activities including anti-cancer, anti-HIV, anti-diabetic, antibacterial, antioxidant, kinase inhibitory, AChE inhibitory, anti-leishmanial,b3 adrenergic receptor agonistic, phosphatase inhibitory, analgesic, spermicidal, vasopressin antagonists,progestero

7、ne antagonists, neuroprotection, NMDA blocker and sleep inducing activities 2.REFERENCES1. Leoni A, et al. 2-Indolinone a versatile scaffold for treatment of cancer: a patent review (2008-2014). Expert Opin Ther Pat.2016;26(2):149-73.2. Kaur M, et al. Oxindole: A chemical prism carrying plethora of therapeutic benefits. Eur J Med Chem. 2016 Nov 10;123:858-894.McePdfHeightCaution: Product has not been fully validated for medical applications.For researc