SIBA-5-Isobutylthioadenosine-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemESIBACat. No.: HY-18684CAS No.: 35899-54-8Synonyms: 5-Isobutylthioadenosine; 5-Deoxy-5-isobutylthioadenosine分式: CHNOS分量: 339.41作靶点: Others作通路: Others储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验

2、DMSO : 100 mg/mL (294.63 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.9463 mL 14.7314 mL 29.4629 mL5 mM 0.5893 mL 2.9463 mL 5.8926 mL10 mM 0.2946 mL 1.4731 mL 2.9463 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储

3、备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (7.37 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (7.37 mM); Clear solution1/2 Master

4、of Small Molecules 您边的抑制剂师www.MedChemE3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (7.37 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 SIBA选择性抑制精胺合成酶, IC50= 8 uM。REFERENCES1. Carteni-Farina M, et al. Studies on the metabolism of 5-isobutylthioadenosine (SIBA): phosphorolytic cleavage bymethy

5、lthioadenosinephosphorylase. FEBS Lett. 1979 Aug 15;104(2):266-270.2. Lawrence F, et al. Effect of 5-deoxy-5-isobutylthioadenosine on putrescine uptake and polyamine biosynthesis by chickembryofibroblasts. Biochem J. 1982 Jun 15;204(3):853-859.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-58