Xanthine-Oxidase-Inhibitors-Modulators-MCE

1、 HYPERLINK https:/www.MedChemE/Targets/Xanthine Oxidase.html Xanthine HYPERLINK https:/www.MedChemE/Targets/Xanthine Oxidase.html HYPERLINK https:/www.MedChemE/Targets/Xanthine Oxidase.html OxidaseXOXanthine oxidase (XO), a versatile molybdoflavoprotein, catalyzes the oxidative hydroxylation of puri

2、ne substrates (hypoxanthineand xanthine) to produce uric acid and subsequent reduction of oxygen at the flavin center with the generation of reactive oxygenspecies, either superoxide anion radical or hydrogen peroxide.Xanthine oxidase is an important enzyme of purine catabolism pathway and has been

3、associated directly in pathogenesis of goutand indirectly in many pathological conditions like cancer, diabetes and metabolic syndrome. The selective inhibition of xanthineoxidase may result in a broad spectrum therapeutic use for gout, cancer, inflammation and oxidative damage.www.MedChemE 1 HYPERL

4、INK https:/www.MedChemE/Targets/Xanthine Oxidase.html Xanthine HYPERLINK https:/www.MedChemE/Targets/Xanthine Oxidase.html HYPERLINK https:/www.MedChemE/Targets/Xanthine Oxidase.html Oxidase HYPERLINK https:/www.MedChemE/Targets/Xanthine Oxidase.html HYPERLINK https:/www.MedChemE/Targets/Xanthine Ox

5、idase.html Inhibitors HYPERLINK https:/www.MedChemE/Allopurinol.html Allopurinol HYPERLINK https:/www.MedChemE/Allopurinol.html HYPERLINK https:/www.MedChemE/allopurinol-sodium.html Allopurinol HYPERLINK https:/www.MedChemE/allopurinol-sodium.html HYPERLINK https:/www.MedChemE/allopurinol-sodium.htm

6、l sodiumCat. No.: HY-B0219 Cat. No.: HY-B0219AAllopurinol is a potent xanthine oxidase inhibitor(IC values of 0.2 to 50 M). Allopurinol can be50used for the research of hyperuricemia and gout.Antileishmanial effect.Allopurinol sodium is a potent xanthine oxidaseinhibitor (IC values of 0.2 to 50 M).5

7、0Allopurinol sodium can be used for the research ofhyperuricemia and gout. Antileishmanial effect.Purity: 99.92%Clinical Data: LaunchedSize: 10 mM 1 mL, 500 mg, 5 g, 10 gPurity: 98%Clinical Data: LaunchedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/allopurinol-d2.html Allopurinol-d2Cat. No.: HY-B0

8、219S HYPERLINK https:/www.MedChemE/Baicalein.html Baicalein(5,6,7-Trihydroxyflavone) Cat. No.: HY-N0196Allopurinol-d2 is deuterium labeled Allopurinol.Allopurinol is a potent xanthine oxidase inhibitor(IC50 values of 0.2 to 50 M). Allopurinol can beused for the research of hyperuricemia and gout.Ant

9、ileishmanial effect.Baicalein (5,6,7-Trihydroxyflavone) is a xanthineoxidase inhibitor with an IC value of 3.12 M.50Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 99.13%Clinical Data: LaunchedSize: 10 mM 1 mL, 100 mg HYPERLINK https:/www.MedChemE/Benzbromarone.html Benzbrom

10、arone HYPERLINK https:/www.MedChemE/Benzbromarone.html HYPERLINK https:/www.MedChemE/benzbromarone-d5.html Benzbromarone-d5Cat. No.: HY-B1135 Cat. No.: HY-B1135SBenzbromarone is a highly effective and welltolerated non-competitive inhibitor of xanthineoxidase, used as an uricosuric agent, used in th

11、etreatment of gout.Benzbromarone-d5 is deuterium labeledBenzbromarone.Purity: 99.80%Clinical Data: LaunchedSize: 10 mM 1 mL, 100 mgPurity: 98%Clinical Data:Size: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/broussoflavonol-f.html Broussoflavonol HYPERLINK https:/www.MedChemE/broussoflavonol-f.html HYPER

12、LINK https:/www.MedChemE/broussoflavonol-f.html F HYPERLINK https:/www.MedChemE/broussoflavonol-f.html HYPERLINK https:/www.MedChemE/Febuxostat.html FebuxostatCat. No.: HY-N9330(TEI 6720; TMX 67) Cat. No.: HY-14268Broussoflavonol F possess xanthine oxidaseinhibitory activity.Febuxostat (TEI 6720) is

13、 selective xanthine oxidaseinhibitor with a K of 0.6 nM.iPurity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mgPurity: 99.90%Clinical Data: LaunchedSize: 10 mM 1 mL, 10 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/Febuxostat-D9.html Febuxostat HYPERLINK https:/www.MedChemE/Febu

14、xostat-D9.html HYPERLINK https:/www.MedChemE/Febuxostat-D9.html D9 HYPERLINK https:/www.MedChemE/Febuxostat-D9.html HYPERLINK https:/www.MedChemE/febuxostat-d7.html Febuxostat-d7Cat. No.: HY-14268S(TEI 6720-d7; TMX 67-d7) Cat. No.: HY-14268S1Febuxostat D9 is deuterium labeled Febuxostat,which is a s

15、elective xanthine oxidase inhibitorwith a K of 0.6 nM.iFebuxostat-d7 is deuterium labeled Febuxostat.Febuxostat (TEI 6720) is selective xanthineoxidase inhibitor with a Ki of 0.6 nM.Purity: 98.0%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSi

16、ze: 1 mg, 5 mg2 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMedChemE HYPERLINK https:/www.MedChemE/forsythoside-f.html Forsythoside HYPERLINK https:/www.MedChemE/forsythoside-f.html HYPERLINK https:/www.MedChemE/forsythoside-f.html F(Arenarioside) Cat. No.: HY-N7397 HYPERLINK https:/www.MedChemE

17、/ilexoside-o.html Ilexoside HYPERLINK https:/www.MedChemE/ilexoside-o.html HYPERLINK https:/www.MedChemE/ilexoside-o.html OCat. No.: HY-N9324Forsythoside F (Arenarioside) is a xanthine oxidaseinhibitor and possesses antihyperuricemic effectsin vivo.Ilexoside O is a triterpene saponin isolated fromth

18、e roots of Ilex pubescens. Ilexoside O exhibitsweak xanthine oxidase (XOD) inhibitory activity(IC =53.05 M).50Purity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mgPurity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mg HYPERLINK https:/www.MedChemE/Lobetyolin.ht

19、ml Lobetyolin HYPERLINK https:/www.MedChemE/Lobetyolin.html HYPERLINK https:/www.MedChemE/myricetin-3-o-galactoside.html Myricetin HYPERLINK https:/www.MedChemE/myricetin-3-o-galactoside.html HYPERLINK https:/www.MedChemE/myricetin-3-o-galactoside.html 3-O-galactosideCat. No.: HY-N0327 Cat. No.: HY-

20、N3220Lobetyolin, a bioactive compound, is derived fromCodonopsis pilosula. Lobetyolin hasanti-inflammatory, anti-oxidative and xanthineoxidase inhibiting activities. Lobetyolin alsoinduces the apoptosis via the inhibition ofASCT2-mediated glutamine metabolism.Myricetin 3-O-galactoside inhibits xanth

21、ine oxidase(XO) activity, lipid peroxidation and scavengesthe free radical. Myricetin 3-O-galactosideinhibits lipid peroxidation with an IC of50160 g/mL. Antioxidant activity.Purity: 99.89%Clinical Data: No Development ReportedSize: 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10

22、 mg, 25 mg HYPERLINK https:/www.MedChemE/nequinate.html Nequinate HYPERLINK https:/www.MedChemE/nequinate.html HYPERLINK https:/www.MedChemE/o-desisobutyl-o-n-propyl-febuxostat.html O-Desisobutyl-O-n-propyl HYPERLINK https:/www.MedChemE/o-desisobutyl-o-n-propyl-febuxostat.html HYPERLINK https:/www.M

23、edChemE/o-desisobutyl-o-n-propyl-febuxostat.html FebuxostatCat. No.: HY-116433 Cat. No.: HY-131268Nequinate, a quinoline compound, is ananticoccidial agent against cecal coccidiosis(Eimeria tenella) infections. Nequinate inhibitsxanthine oxidoreductase (XOD) activity.O-Desisobutyl-O-n-propyl Febuxos

24、tat, extractedfrom the patent CN 103467412, is an xanthine oxidaseinhibitor.Purity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mg, 50 mg, 100 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/1,2-dihydropyrazolo-3,4-d-pyrimidine-4,6

25、-dione.html Oxypurinol HYPERLINK https:/www.MedChemE/1,2-dihydropyrazolo-3,4-d-pyrimidine-4,6-dione.html HYPERLINK https:/www.MedChemE/Phytic_acid.html Phytic HYPERLINK https:/www.MedChemE/Phytic_acid.html HYPERLINK https:/www.MedChemE/Phytic_acid.html acid HYPERLINK https:/www.MedChemE/Phytic_acid.

26、html (Inositol hexaphosphate; myo-Inositol,(Oxipurinol) Cat. No.: HY-19657 hexakis(dihydrogen phosphate) Cat. No.: HY-N0814Oxipurinol (Oxipurinol), the major activemetabolite of Allopurinol, is an inhibitor ofxanthine oxidase. Oxipurinol can be used to regulateblood urate levels and treat gout.Phyti

27、c acid is a phosphorus storage compound ofseeds and cereal grains. Phytic acid is known as afood inhibitor, which has a strong ability tochelate multivalent metal ions, specially zinc,calcium, iron and as with protein residue.Purity: 98.0%Clinical Data: Phase 3Size: 10 mM 1 mL, 50 mgPurity: 95.0%Cli

28、nical Data: LaunchedSize: 250 mg (757.5 mM * 500 L in Water) , HYPERLINK https:/www.MedChemE/Phytic_acid_dodecasodium_salt_hydrate.html Phytic HYPERLINK https:/www.MedChemE/Phytic_acid_dodecasodium_salt_hydrate.html HYPERLINK https:/www.MedChemE/Phytic_acid_dodecasodium_salt_hydrate.html acid HYPERL

29、INK https:/www.MedChemE/Phytic_acid_dodecasodium_salt_hydrate.html HYPERLINK https:/www.MedChemE/Phytic_acid_dodecasodium_salt_hydrate.html dodecasodium HYPERLINK https:/www.MedChemE/Phytic_acid_dodecasodium_salt_hydrate.html HYPERLINK https:/www.MedChemE/Phytic_acid_dodecasodium_salt_hydrate.html s

30、alt HYPERLINK https:/www.MedChemE/Phytic_acid_dodecasodium_salt_hydrate.html HYPERLINK https:/www.MedChemE/Phytic_acid_dodecasodium_salt_hydrate.html hydrate HYPERLINK https:/www.MedChemE/Phytic_acid_dodecasodium_salt_hydrate.html (Inositol hexaphosphate HYPERLINK https:/www.MedChemE/prudomestin.htm

31、l Prudomestindodecasodium salt hydrate; ) Cat. No.: HY-N0814ACat. No.: HY-N1547Phytic acid dodecasodium salt hydrate is aphosphorus storage compound of seeds and cerealgrains.Prudomestin, isolated from the heartwood of Prunusdomestica, shows potent xanthine oxidase (XO)inhibitory activity (IC 6M).50

32、Purity: 98.0%Clinical Data: Phase 3Size: 250 mgPurity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mgwww.MedChemE 3 HYPERLINK https:/www.MedChemE/purpurogallin.html PurpurogallinCat. No.: HY-12136 HYPERLINK https:/www.MedChemE/tigulixostat.html Tigulixostat(LC350189) Cat. No.: HY-139585P

33、urpurogallin is a naturally phenol extracted fromthe plants of Quercus spp, has potent xanthineoxidase (XO) inhibitory activity with an IC of500.2 M. Purpurogallin has antioxidant andanti-inflammatory effects.Tigulixostat (LC350189) is an orally active,non-purine selective xanthine oxidase inhibitor

34、.Tigulixostat lowers the production of uric acid.Tigulixostat can be used for gout andhyperuricemia study.Purity: 98%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mgPurity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg HYPER

35、LINK https:/www.MedChemE/Topiroxostat.html Topiroxostat(FYX-051) Cat. No.: HY-14874 HYPERLINK https:/www.MedChemE/topiroxostat-d4.html Topiroxostat-d4(FYX-051-d4) Cat. No.: HY-14874STopiroxostat (FYX-051) is a potent and orallyactive xanthine oxidoreductase (XOR) inhibitorwith an IC50 value of 5.3 n

36、M and a Ki value of 5.7nM. Topiroxostat exhibits weak CYP3A4-inhibitoryactivity (18.6%). Topiroxostat has the potentialfor hyperuricemia treatment.Topiroxostat-d4 is deuterium labeled Topiroxostat.Topiroxostat (FYX-051) is a potent and orallyactive xanthine oxidoreductase (XOR) inhibitorwith an IC50

37、 value of 5.3 nM and a Ki value of 5.7nM. Topiroxostat exhibits weak CYP3A4-inhibitoryactivity (18.6%).Purity: 99.68%Clinical Data: LaunchedSize: 10 mM 1 mL, 10 mg, 25 mg, 50 mg, 100 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/Benzoic_acid,_4-_3-

38、cyano-5,6-difluoro-1H-indol-1-yl_-2-hydroxy-.html Xanthine HYPERLINK https:/www.MedChemE/Benzoic_acid,_4-_3-cyano-5,6-difluoro-1H-indol-1-yl_-2-hydroxy-.html HYPERLINK https:/www.MedChemE/Benzoic_acid,_4-_3-cyano-5,6-difluoro-1H-indol-1-yl_-2-hydroxy-.html oxidase-IN-1(4-(3-Cyano-5,6-difluoroindol-1

39、-yl)-2-hydroxybenzoic acid) Cat. No.: HY-U00288 HYPERLINK https:/www.MedChemE/xanthine-oxidase-in-4.html Xanthine HYPERLINK https:/www.MedChemE/xanthine-oxidase-in-4.html HYPERLINK https:/www.MedChemE/xanthine-oxidase-in-4.html oxidase-IN-4Cat. No.: HY-144303Xanthine oxidase-IN-1 is a xanthine oxida

40、seinhibitor extracted from patent WO2008126898A1,page 68, compound example 3, with an IC of 6.550nM.Xanthine oxidase-IN-4 (compound 19a) is an orallyactive and potent xanthine oxidase (XO) inhibitor,with an IC of 0.039 M. Xanthine oxidase-IN-450exhibits hypouricemic potency in potassium oxonateinduc

41、ed hyperuricemia rats. Xanthine oxidase-IN-4can be used for hyperuricemia and gout research.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/xanthine-oxidase-in-5.html Xanthine HYPERLINK https:/www.MedChemE/xanthine-oxidase-in-5.html HYPERLINK https:/www.MedChemE/xanthine-oxid