子宫腺肌症常见和不常见的MRI 课件

1、子宫腺肌症常见和不常见的MRI表现2021/5/71Adenomyosis is a common nonneoplastic gynecologic disease characterized by the presence of ectopic endometrium within the myometrium .Adenomyosis typically affects multiparous, premenopausal women over 30 years of age and may cause dysmenorrhea, menorrhagia, and abnormal ge

2、nital bleeding .子宫腺肌症是一种常见的非肿瘤性妇科疾病，是发生在子宫肌层的子宫内膜异位症。其主要发生于超过30岁，绝经前的经产妇并且可能引起痛经，月经过多和不正常的阴道出血的症状。Magnetic resonance (MR) imaging is a noninvasive modality with high sensitivity and specificity for diagnosis of adenomyosis . In cases of an enlarged uterus revealed with ultrasonography, MR imaging al

3、lows differentiation of adenomyosis from leiomyoma or other pathologic conditions owing to its excellent tissue contrast resolution .磁共振（MR）成像是一种非侵入性的检查方式，其在诊断子宫腺肌症上具有高的灵敏度和特异度。当超声检查中发现子宫增大时，磁共振由于其出色的组织对比分辨率可以把子宫腺肌症与子宫肌瘤或其他疾病鉴别出来。 Introduction2021/5/72On T2-weighted images, typical adenomyosis appea

4、rs as an ill-demarcated low-signal-intensity lesion with uterine enlargement. However, various physiologic or pathologic states may affect the MR imaging appearance of adenomyosis and may result in a tumorlike appearance 在T2WI上，子宫腺肌症的典型表现为一个边界不清的低信号强度病变伴随着子宫增大。然而，多种生理和病理改变也许会影响子宫腺肌症的MRI表现并且会导致其出现肿瘤样

5、的表现Specific topics discussed are MR imaging manifestations of typical adenomyosis, atypical MR imaging manifestations of adenomyosis, pitfalls in diagnosis of adenomyosis, 讨论的具体话题包括子宫腺肌症的典型MRI表现，子宫腺肌症的不典型MRI表现，子宫腺肌症的诊断误区Introduction2021/5/73MR Imaging Manifestations of Typical Adenomyosis子宫腺肌症的典型MRI

6、表现2021/5/74 Typical AdenomyosisAt pathologic analysis, adenomyosis is characterized by the presence of ectopic endometrial glands and stroma within the myometrium with hypertrophy and hyperplasia of smooth muscleAdenomyosis may affect the uterine myometrium diffusely and result in a diffusely enlarg

7、ed uterus, or it may be localized as an adenomyoma.病理分析，子宫腺肌症的特征性表现是子宫肌层内异位的子宫内膜腺体和间质的存在和平滑肌的肥大增生。子宫腺肌症也许会弥漫性的影响子宫肌层并导致子宫弥漫性的增大，或者会作为腺肌瘤局限性的影响肌层2021/5/75A cut section of a diffusely adenomyotic uterus shows thickened myometrium due to the ill-defined adenomyosis; the thickened myometrium is composed

8、 of haphazardly distributed hypertrophied muscular trabeculae surrounding ectopic endometrial tissue (Fig 1) . Brownish old hemorrhagic foci corresponding to hemolysed blood and hemosiderin pigment deposits may be contained within the area of adenomyosis弥漫型腺肌型子宫的横断面显示由于界限不清的子宫腺肌病导致肌层增厚。肥厚的肌层是由随意分布的肥

9、大性肌小梁及周围的异位子宫内膜组织所构成（图1）。褐色的旧出血灶也许对应着子宫腺肌症区域内的出血和含铁血黄素沉积 Typical Adenomyosis2021/5/76Fig. 1A 1B1A1BFigure 1. Adenomyosis in a 47-year-old woman. 47岁女性，子宫腺肌症患者，(a) Photograph of the cut surface of the gross specimen shows diffusely thickened myometrium. (b) photomicrograph (hematoxylin-eosin stain) s

10、hows ectopic endometrial glands and stroma (arrow) surrounded by hypertrophied smooth muscle.a.大体标本的切面照片显示弥漫性增厚的子宫肌层 b.显微镜下照片（HE染色）显示异位的子宫内膜腺体和间质和周围的肥厚的平滑肌 2021/5/77Typical adenomyosis appears as an ill-demarcated low-signal-intensity area on T2-weighted images owing to abundant smooth muscle prolif

11、eration (Fig 2) .Because adenomyotic endometrium looks like the basalis endometrium, which seldom responds to hormonal stimuli, cyclic changes including degeneration, bleeding, and regeneration are less common in adenomyosis than in endometriosis . 子宫腺肌症的典型表现是在T2WI上有一界限不清的低信号区域，这是由于丰富的平滑肌细胞增殖。因为腺肌症子

12、宫内膜跟基底子宫内膜一样，很少对激素的刺激做出反应，所以与其他子宫内膜异位症相比，包括变性，出血，再生这样的周期性的变化较少出现在子宫腺肌症中On T2-weighted MR images, ectopic endometrium appears as small high-signal-intensity areas like normal endometrium (Fig 2). Small cysts may also appear as high-signal-intensity spots on T2- weighted images.Sometimes, hemorrhagic

13、foci appear as 13mm high-signal-intensity foci on T1-weighted images owing to the T1-shortening effects of methemoglobin (Fig 2)在T2WI图像上，异位子宫内膜表现为跟正常子宫内膜一样的小的片状高信号，小的囊肿也可能在T2WI上表现为点状高信号。有时候由于高铁血红蛋白T1缩短效应的影响，出血灶在T1WI上表现为1-3mm的高信号病灶 Typical Adenomyosis2021/5/78Susceptibility-weighted imaging is sensit

14、ive for old hemorrhagic foci, which appear as spotty signal voids owing to the T2*-shortening effects of hemosiderin . At diffusion-weighted imaging, adenomyosis has low to intermediate signal intensity, a finding consistent with its benign, nonneoplastic nature (Fig 3) 磁敏感加权成像对陈旧出血灶很敏感，由于含铁血黄素T2缩短效

15、应的影像，表现点状低信号。在弥散加权像上，子宫腺肌症表现为低到中等信号强度，这种表现其实与它是良性，非肿瘤性病变这种性质相一致However, there is no direct correlation between signal intensity at diffusion-weighted imaging and malignancy; most malignant tumors have very high signal intensity at diffusion-weighted imaging, a finding that reflects the long T2 relax

16、ation time and restricted diffusion due to high cellularity.然而，DWI上信号强度和恶性病变之间并没有直接的相关性；大多数的恶性肿瘤在DWI上有非常高的信号强度，这反映了由于长的T2弛豫时间和高的细胞密度导致的扩散受限。 Typical Adenomyosis2021/5/79Figure 2. Adenomyosis in a 46-year-old woman. 46岁女性，子宫腺肌症患者(a) Sagittal T2-weighted fast spin-echo MR image shows an enlarged uteru

17、s with an ill-defined low-signal-intensity lesion (arrow) in the posterior myometrium. The lesion contains multiple small high-signal-intensity areas, which represent ectopic endometrial tissue and small cysts.矢状位T2加权快速自旋回波MR图像显示子宫增大，伴随一个子宫肌层后壁内界限不清的低信号强度的病变（箭头处），病变包含多个小的高信号的区域，其代表了子宫内膜异位组织和小囊肿 (b)

18、Sagittal T1-weighted spin-echo MR image shows high-signal-intensity spots (arrow), which correspond to some of the small high-signal-intensity areas seen on the T2-weighted image.The high-signal-intensity spots represent hemorrhage within the ectopic endometrial tissue.矢状位T1加权自旋回波MR图像显示了点状高信号，它们对应了在

19、T2WI上看到的一些小的高信号区域。这些点状高信号代表了子宫内膜组织内的出血2021/5/7109、 人的价值，在招收诱惑的一瞬间被决定。2022/7/112022/7/11Monday, July 11, 202210、低头要有勇气，抬头要有低气。2022/7/112022/7/112022/7/117/11/2022 10:55:46 PM11、人总是珍惜为得到。2022/7/112022/7/112022/7/11Jul-2211-Jul-2212、人乱于心，不宽余请。2022/7/112022/7/112022/7/11Monday, July 11, 202213、生气是拿别人做错的

20、事来惩罚自己。2022/7/112022/7/112022/7/112022/7/117/11/202214、抱最大的希望，作最大的努力。11 七月 20222022/7/112022/7/112022/7/1115、一个人炫耀什么，说明他内心缺少什么。七月 222022/7/112022/7/112022/7/117/11/202216、业余生活要有意义，不要越轨。2022/7/112022/7/1111 July 202217、一个人即使已登上顶峰，也仍要自强不息。2022/7/112022/7/112022/7/112022/7/112021/5/711Figure 3. Adenomy

21、osis in a 42-year-old woman. (a) Sagittal diffusion-weighted echo-planar MR image (b = 800 sec/mm2) shows an enlarged uterus with an ill-defined lesion of low to intermediate signal intensity (arrow) in the posterior myometrium. (b) Corresponding apparent diffusion coefficient (ADC) map shows no pro

22、minent decrease of ADC value in the area of adenomyosis (arrow).a.矢状位扩散加权回波平面MR图像(b = 800 sec/mm2)显示增大的子宫伴随后壁肌层内界限不清的病变，呈低到中等信号强度（箭头）。b.相应的ADC图上在子宫腺肌症的区域内没有显示出明显的ADC值的下降2021/5/712Because adenomyosis may show various degrees of enhancement after administration of contrast medium, contrast-enhanced st

23、udy does not contribute to diagnostic accuracy (Fig 4).Dynamic contrast-enhanced imaging may have greater accuracy than T2-weighted imaging when adenomyosis and endometrial cancer coexist (16). 因为在注射造影剂后，子宫腺肌症可能显示为不同程度的强化，所以关于其对比增强的研究对诊断的准确性没有帮助（图4）。 当子宫腺肌症和子宫内膜癌同时存在时动态对比增强图像也许会比T2加权图像更准确However, th

24、e heterogeneous enhancement of adenomyosis may cause inaccuracy when evaluating the depth of myometrial invasion by coexisting endometrial cancer; diffusion-weighted imaging may be helpful in accurately determining the depth of myometrial invasion .然而当并发子宫内膜癌时，子宫腺肌症不均质的强化可能会导致评估肌层浸润深度的不准确；扩散加权成像也许会帮

25、助准确的确定肌层浸润深度 Typical Adenomyosis2021/5/713Diffusion-weighted ImagingDiffusion-weighted imaging allows visualization of the local microstructural characteristics of water diffusion. The signal intensity seen on diffusion-weighted images is a combination of the degree of water diffusion and the signal

26、 intensity of the underlying T2-weighted images.扩散加权图像能够可视化水分子扩散的微观结构特征，在DWI上看的信号强度是水分子扩散程度和基础T2加权图像信号强度的结合。In oncologic imaging, various malignant tumors may show high signal intensity at diffusion-weighted imaging due to their high cellularity and long T2 relaxation time 在肿瘤成像上，由于高的细胞密度和长的T2弛豫时间，各

27、种恶性肿瘤在DWI上显示为高信号。 ADC measurement yields quantitative information about tissue structure that is based on the molecular motion of water. Malignant lesions with increased cellularity show low ADC values, whereas relatively hypocellular benign lesions and normal structures tend to show relatively high

28、er ADC values.ADC图以水分子的运动为基础来测量组织结构的定量信息。高的细胞密度大的病变表现出低的ADC值，而相对低度增生的良性病变和正常组织显示相对高的ADC值 Typical Adenomyosis2021/5/714Figure 4. Adenomyosis in a 47-year-old woman. 47岁女性，子宫腺肌症患者(a) Sagittal T2-weighted fast spin-echo MR image shows an enlarged uterus with an ill-defined low-signal-intensity lesion (

29、arrow) in the posterior myometrium. The lesion contains multiple small high-signal-intensity areas.(b) Unenhanced (upper left), early arterial phase (upper right), late arterial phase (lower left), and venous phase (lower right) images, obtained with a dynamic gadolinium-enhanced three-dimensional f

30、ast spoiled gradient-echo sequence with fat suppression, show heterogeneous and gradual enhancement of the lesion.a.矢状位T2加权快速自旋回波MR图像显示子宫增大伴随子宫肌层后壁内界限不清的低信号强度病变。病变内包含多个小的高信号强度区域b.由一个压脂动态钆增强型三维快速小角度梯度回波序列获得平扫（左上图），动脉早期相（右上图），动脉晚期相（左上图），以及静脉相（右下图），病变表现为不均匀和渐进性的强化。2021/5/715Atypical MR Imaging Manifest

31、ations of Adenomyosis子宫腺肌症的非典型MRI表现2021/5/716Atypical Adenomyosis Various physiologic or pathologic states may affect the MR imaging appearance of adenomyosis: amount of functional endometrial tissue, phase of the menstrual cycle, endogenous hormonal abnormality, and exogenous hormonal stimulation.

32、Secretory transformation of adenomyotic endometrium including stromal decidualizationmay cause a heterogeneous increase in signal intensity on T2-weighted images.多种生理或病理状态可能会影响子宫腺肌症的MRI表现：功能性子宫内膜组织的量，月经周期的阶段，内源激素的异常，外源激素的刺激。腺肌症子宫内膜的分泌转化包括间质蜕膜化会导致T2WI上信号强度不均质的提高This phenomenon may be encountered duri

33、ng gestation and exogenous progestational therapy or even in patients without specific hormonal stimulation. Congestion or edematous change may also increase the signal intensity of adenomyosis diffusely or focally on T2-weighted images (Fig 5). 这种现象可能发生于怀孕期间，外源性孕激素治疗期间，或者甚至在没有特定激素刺激的患者身上。充血或水肿的变化也可

34、能会在T2WI上弥漫性增加子宫腺肌症的信号强度或者局部信号强度（图5）。2021/5/717In such conditions, MR imaging manifestations may fluctuate, and follow-up MR imaging may be helpful for diagnosis. Gonadotropin-releasing hormone analog is used in the treatment of adenomyosis. After hormonal therapy or menopause, an area of adenomyosis

35、 may shrink with decreased signal intensity on T2-weighted images(Fig 6)在这种情况下，MRI表现会变化较大，再一次的复查对诊断有帮助。促性腺激素释放激素类似物被用于治疗子宫腺肌症。激素治疗后或在绝经期时，子宫腺肌症的面积可能会萎缩，并伴随着T2WI上信号强度的降低(图6)。Atypical Adenomyosis 2021/5/718Figure 5. Adenomyosis with focal edema in a 54-year-old woman. (a) Sagittal T2-weighted fast spi

36、n-echo MR image shows an enlarged uterus with an ill-defined low-signal-intensity lesion in the posterior myometrium. The low-signal-intensity lesion contains a focal high-signal-intensity masslike area (arrow).(b) On diffusion weighted echo-planar MR image (b = 800 sec/ mm2), the high-signal-intens

37、ity masslike area in a sagittal shows no increase in signal intensity (arrow). a.矢状位T2加权快速自旋回波MR图像显示增大的子宫伴随子宫后壁内界限不清的低信号强度病变。这个低信号病变内包含一个肿块样高信号强度区域（箭头）b.在矢状位扩散加权平面回波MR图像上 (b = 800 sec/ mm2) ，这个高信号强度肿瘤样区域没有显示信号强度的增高（箭头）2021/5/719Figure 5.（c ） On an image from MR spectroscopy, the high-signal-intensit

38、y masslike area shows a low choline peak (Cho) at 3.2 ppm. Biopsy revealed benign adenomyotic tissue with stromal edema. The signal intensity of the masslike area is decreased on follow-up T2-weighted images obtained 3 months later. c.在磁共振波谱上，这个高信号强度的肿块样区域在3.2ppm处显示为低的胆碱峰（Cho）。活检发现良性子宫腺肌组织间质水肿，这个肿块样

39、区域的信号强度在3个月后的T2WI图像上降低。MR spectroscopy2021/5/720Figure 6. Adenomyosis in a 50-year-old woman before and after hormonal therapy with gonadotropinre leasing hormone analog.一个50岁女性，子宫腺肌症患者，促性腺激素释放激素类似物治疗前后(a)Axial T2-weighted fast spin-echo MR image shows adenomyosis as an ill-defined heterogeneous low

40、-signal-intensity lesion with linear or reticular high-signal-intensity areas in the anterior myometrium (arrow). (b) Axial T2-weighted fast spin-echo MR image obtained after hormonal therapy shows decreased volume and signal intensity of the area of adenomyosis (arrow). a.在轴位T2加权快速自旋回波MR图像上，子宫腺肌症显示

41、为边界不清的不均匀的低信号强度病变伴随肌层前壁线状或网状高信号强度区域（箭头） b.激素治疗后，获取的轴位T2加权快速自旋回波MR图像显示子宫腺肌症区域的面积和信号强度都下降了2021/5/721In such conditions, MR imaging manifestations may fluctuate, and follow-up MR imaging may be helpful for diagnosis. Gonadotropin-releasing hormone analog is used in the treatment of adenomyosis. After h

42、ormonal therapy or menopause, an area of adenomyosis may shrink with decreased signal intensity on T2-weighted images(Fig 6) 在这种情况下，MRI表现会变化较大，再一次的复查对诊断有帮助。促性腺激素释放激素类似物被用于治疗子宫腺肌症。激素治疗后或绝经期子宫腺肌症的面积可能会萎缩，并伴随着T2WI上信号强度的降低。Diffusion-weighted imaging with ADC measurement may provide another clue for the

43、diagnosis, because these conditions (secretory transformation, decidualization, congestion or edema) usually increase the ADC in tissues. A relatively high ADC in adenomyotic lesions with high signal intensity on T2-weighted images may allow differentiation from malignant lesions, which have a low A

44、DC due to their high cellularity (Fig 5) (15). 弥散加权成像图像上ADC值的测量可能提供诊断的另一条线索，因为在这些情况下（分泌转化，蜕膜变，充血或水肿）通常会增加组织的ADC值。子宫腺肌症病灶的一个相对高的ADC值和高的T2信号强度可以将其从恶性病变中鉴别出来，因为恶性病变由于其高的细胞密度导致低的ADC值MR spectroscopy may also provide a clue for the diagnosis, because these benign adenomyotic conditions do not show high me

45、tabolic activity. A relatively low choline peak in adenomyotic lesions may allow differentiation from malignant tumors, which show a high choline peak due to their high metabolic activity (Fig5)磁共振质子波谱也可以提供诊断线索，因为这些良性的腺肌并没有表现为高的代谢活动。子宫腺肌症病变的一个相对低的胆碱峰有助于将其与恶性肿瘤鉴别开，因为恶性肿瘤由于其高的代谢活动显示为高的胆碱峰。Atypical Ade

46、nomyosis 2021/5/722Pitfalls in Diagnosis of Adenomyosis子宫腺肌症诊断中的陷阱2021/5/723The uterine body may show physiologic changes during the menstrual cycle. The low-signal-intensity junctional zone and adenomyosis are well visualized due to increased signal intensity of the myometrium in the secretory phas

47、e (luteal phase). 子宫体在月经周期中表现了生理性的变化。由于在分泌期（黄体期）时子宫肌层信号变高，导致能清楚的看到低信号的结合带和子宫腺肌症Decreased signal intensity of the myometrium in the menstrualearly proliferative phase (follicular phase) may cause widening of the junctional zone, which mimics diffuse adenomyosis. Therefore, MR imaging for the evaluati

48、on of a uterine myometrial lesion should be performed in the late proliferativesecretory phase (Fig 7)肌层在月经早期增殖期（卵泡期）信号强度的下降会引起结合带的增宽，使其像弥漫性子宫腺肌症。因此MRI对子宫肌层的评价应该在增生晚期-分泌期进行（图7）Physiologic Changes in the Uterine Body during the Menstrual Cycle 在月经周期中子宫体的生理变化2021/5/724Figure 7. Subserosal adenomyosis-

49、like lesion (invasive solid endometriosis) in a 33-year-old woman during different phases of the menstrual cycle. (a) Sagittal T2-weighted fast spin-echo MR image obtained in the early proliferative phase shows decreased signal intensity of the myometrium. The boundary between the myometrium and a s

50、ubserosal adenomyosis-like lesion (arrow) is obscure.(b) Sagittal T2-weighted fast spin-echo MR image obtained in the late secretory phase shows increased signal intensity of the myometrium. The low-signal-intensity junctional zone and the subserosal adenomyosis-likelesion (arrow) are clearly visual

51、ized.33岁女性，浆膜下的子宫腺肌样病变，在月经周期的不同阶段a.在增殖早期时相获取的矢状位T2加权快速自旋回波MR图像显示肌层信号强度的下降。肌层和浆膜下子宫腺肌样病变之间的界限是模糊的b.在分泌晚期阶段获得的矢状位T2加权快速自旋回波MR图像显示肌层信号强度增高。低信号强度的结合带和浆膜下腺肌样病变清晰可见2021/5/725Various benign conditions and malignant tumors may mimic adenomyosis: physiologic myometrial contraction, myometrial involvement by

52、pelvic endometriosis, low-grade endometrial stroma sarcoma (LG-ESS), and myometrial metastases 多种良性改变和恶性肿瘤类似于子宫腺肌症：生理肌层收缩，肌层受累的盆腔子宫内膜异位症，低度恶性子宫内膜间质肉瘤（LG-ESS），和肌层转移 Transient myometrial contraction as a physiologic phenomenon may mimic adenomyosis; this appearance may disappear on subsequent images o

53、r at cine MR imaging, whereas focal adenomyosis persists on subsequent images or at cine MR imaging (Fig 8) In the pregnant uterus, myometrium adjacent to the implant site may show low signal intensity, which reflects blood supplying a contraction; this finding mimics physiologic contraction or foca

54、l adenomyosis (Fig 9) . 作为一种生理现象的瞬态肌层收缩类似于子宫腺肌症，这种外观可能会消失在随后的图像或电影MRI图像，而局灶性子宫腺肌病持续的存在于随后的图像或电影MR成像。在怀孕的子宫，子宫肌层植入的地方表现为低信号，这反映了血液供给的收缩；这个表现类似于生理性收缩或局灶性腺肌病。Contractions in the pregnant uterus are commonly seen and usually do not present a diagnostic dilemma; however, radiologists who are not familiar

55、 with MR imaging of pregnant women may misdiagnose the contraction 孕妇子宫的收缩很常见，通常不存在诊断的难题，然而，不熟悉怀孕女性MR成像的放射学医生可能会将子宫收缩误诊Benign and Malignant Mimics of Adenomyosis 类似于子宫腺肌症的良性和恶性病变2021/5/726Figure 8. Physiologic transient myometrial contraction in a 32-year-old woman. 发生在一个32岁女性的生理性瞬间肌层收缩Sagittal T2-w

56、eighted fast spin-echo MR image shows focal low-signal-intensity bulging of the myometrium (arrow), a finding that mimics adenomyosis. This finding disappeared on subsequent T2-weighted images.矢状位T2加权快速自旋回波MR图像显示为子宫肌层局灶性低信号强度的膨胀（箭头），这个表现类似于子宫腺肌症。其在接下来的T2WI上消失了。Pitfalls in Diagnosis 2021/5/727Figure

57、9. Transient myometrial contraction during pregnancy in a 31-year-old woman. 一个31岁女性怀孕期间的瞬间肌层收缩(a) Axial T2-weighted fast spin-echo MR image shows a localized area of low signal intensity (arrow) in the uterus, a finding that mimics adenomyosis. Because a rapid T2-weighted sequence (eg, half-Fourier

58、 acquisition single-shot turbo spin-echo or single-shot fast spin-echo) was not used, depiction of the embryo-fetus is poor. (b) Axial susceptibility-weighted gradient-echo MR image shows absence of signal voids (arrow) within the low-signal-intensity area . However, absence of signal voids at susce

59、ptibility-weighted imaging should not be considered to exclude adenomyosis. To establish the diagnosis of a contraction, it would be critical to show the low-signal-intensity area on subsequent T2-weighted images.a.轴位T2加权快速自旋回波MR图像显示子宫内一个局部低信号，类似于子宫腺肌症，因为快速T2加权序列没有使用，导致显示胎儿显示较差b.轴位SWI图显示低信号区域内没有点状低信

60、号，然而在SWI图上缺乏点状低信号并不能排除子宫腺肌症。为了确定生理收缩的诊断，在随后的T2加权图像上显示低信号强度的区域至关重要2021/5/728Susceptibility-weighted imaging can show small hemorrhagic foci in adenomyosis as spotty signal voids and may be helpful in differentiating adenomyosis from focal contraction (Fig 10) . On the other hand, absence of signal vo