浅析莫沙必利对功能性消化不良及近端胃舒张和胃排空功能的效果

1、 浅析莫沙必利对功能性消化不良及近端胃舒张和胃排空功能的效果 【摘要】：目的 针对莫沙必利对功能性消化不良及近端胃舒张和胃排空功能的临床治疗效果展开分析探讨。方法 选取我院2018年6月2019年6月收治的84例功能性消化不良患者作为研究对象，随机分为对照组和观察组，每组各42例。对照组采用常规治疗方法，观察组采用莫沙必利进行治疗，对比两组患者的在治疗前后近端胃舒张和胃排空功能。结果 观察组患者治疗有效率明显高于对照组(p0.05)；治疗后，观察组胃底气体评分及近端胃半排空时间明显优于对照组(p0.05)；10、30、60min治疗后较治疗前比较，差异均有统计学意义(p0.05)；且观察组治疗

2、后10、30、60min与对照组比较差异有统计学意义(p0.05)。结论 采用莫沙必利治疗功能性消化不良，可有效提高患者的近端胃舒张和胃排空功能，治疗效果显著，值得临床推广应用。【关键词】：莫沙必利；功能性消化不良；近端胃舒张；胃排空功能a brief analysis of the effects of mosapride on functional dyspepsia, proximal gastric diastole and gastric emptiesabstract objective: to analyze and discuss the clinical effect of

3、mosapride on functional dyspepsia, proximal gastric diastole and gastric emptation.methods a total of 84 patients with functional dyspepsia admitted to our hospital from june 2018 to june 2019 were selected as study subjects and randomly pided into control group and observation group, with 42 patien

4、ts in each group.the control group was treated with conventional therapy, while the observation group was treated with mosapride.results the treatment efficiency of the observation group was significantly higher than that of the control group (p0.05);after treatment, the gastric fundus gas score and

5、 proximal gastric half empty time in the observation group were significantly better than those in the control group (p0.05);10, 30, 60min after treatment compared with before treatment, the differences were statistically significant (p0.05);moreover, there were statistically significant differences

6、 between the observation group and the control group (p0.05)，可进行比较。1.2方法观察组：给予莫沙必利片3次/天，5mg/次，于餐前30min口服，疗程为2周。对照组：给予吗丁啉多潘立酮片3次/天，10mg/次，于餐前30min口服，疗程为2周。1.3统计学处理采用spss 17.0统计软件进行统计分析，计量资料采用 s表示，组间比较采用t检验，计数资料以率表示，组间比较采用2检验，以p0.05表示差异具有统计学意义。2结果2.1两组患者临床疗效比较经2周的治疗后，对照组总有效率为76.2%；观察组总有效率为95.2%，与对照组比较

7、，差异有统计学意义(p0.05)；治疗后，观察组胃底气体评分及近端胃半排空时间明显优于对照组，差异有统计学意义(p0.05)；10、30、60min治疗后较治疗前比较，差异均有统计学意义(p0.05)；且观察组治疗后10、30、60min与对照组比较差异有统计学意义(p0.05)，见表3。表3 两组患者不同时间近端胃容积改变情况 ( s，ml)组别 例数 治疗前 治疗后0min 10min 30min 60min 0min 10min 30min 60min观察组 42 171.123.2 180.723.1 152.721.4 77.621.5 171.123.6 157.827.3 128

8、.523.2 12.75.4对照组 42 175.326.5 181.423.4 153.222.5 78.720.8 173.826.6 165.726.9 130.420.6 22.35.23讨论功能性消化不良是临床中常见病之一，给患者带来的危害集中表现在上消化道症状引发的不适及可能对患者生活质量的不良影响。在临床实际工作中，有相当部分患者对本疾病认识有所偏差，心理负担较重，且伴发上腹痛、胀，恶心，呕吐等症状，严重影响患者的生活质量。莫沙必利能够有效的修复微粘膜损伤，改善功能性消化不良症状。本文研究结果显示，观察组临床总有效率显著优于对照组，比较差异有统计学意义(p0.05)；且应用观察组在治疗后气体评分、胃半排空时间较治疗前比较差异有统计学意义(p0.05)，说明莫沙必利对胃有较好的舒张以及排空能力。综上所述，莫沙必利在治疗功能性消化不良方面效果理想，而且还能显著改善患者的近端胃舒张功能以及胃排空功能，值得临床推广使用。参考文献1李伟冬,江舒曼,贾林.莫沙必利联合米曲菌胰酶片对功能性消化不良模型小肠cajal间质细胞的影响及其机制的研究j.重庆医学,2019,48(19):3249-3252,3