Thioridazine-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemEThioridazine(Standard)Cat.No.:HY-B0965ARCASNo.:50-52-2分子式:C₂₁H₂₆N₂S₂分子量:370.57作用靶点:DopamineReceptor;Apoptosis;5-HTReceptor;Autophagy;Bacterial作用通路:GPCR/GProtein;NeuronalSignaling;Apoptosis;Autophagy;Anti-infection储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性 Thioridazine(Standard)是Thioridazine的分析标准品。本产品用于研究及分析应用。Thioridazine是一种具有口服活性的多巴胺受体D2家族蛋白的拮抗剂，具有有效的抗焦虑活性。Thioridazine也是一种有效的PI3K-Akt-mTOR信号通路的抑制剂，具有抗血管生成作用。Thioridazine在多种类型的癌细胞中显示出抗增殖和凋亡诱导作用，对靶向癌症干细胞(CSCs)具有特异性。REFERENCESTschanzJT,et,al.Atypicalantipsychoticdrugsblockselectivecomponentsofamphetamine-inducedstereotypy.PharmacolBiochemBehav.1988Nov;31(3):519-22.MuJ,et,al.Thioridazine,anantipsychoticdrug,elicitspotentantitumoreffectsingastriccancer.OncolRep.2014May;31(5):2107-14.KangS,et,al.ThioridazineinducesapoptosisbytargetingthePI3K/Akt/mTORpathwayincervicalandendometrialcancercells.Apoptosis.2012Sep;17(9):989-97.LoehrAR,et,al.TargetingCancerStemCellswithDifferentiationAgentsasanAlternativetoGenotoxicChemotherapyfortheTreatmentofMalignantTesticularGermCellTumors.Cancers(Basel).2021Apr23;13(9):2045.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792Fax:02