20S-Protopanaxatriol-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemE(20S)-Protopanaxatriol(Standard)Cat.No.:HY-N0835RCASNo.:34080-08-5分子式:C₃₀H₅₂O₄分子量:476.73作用靶点:GlucocorticoidReceptor;EstrogenReceptor/ERR;LXR;Apoptosis作用通路:Immunology/Inflammation;VitaminDRelated/NuclearReceptor;MetabolicEnzyme/Protease;Apoptosis储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性 (20S)-Protopanaxatriol(Standard)是(20S)-Protopanaxatriol的分析标准品。本产品用于研究及分析应用。(20S)-Protopanaxatriol是人参皂苷的代谢物，通过结合糖皮质激素受体(glucocorticoidreceptor)和雌激素受体(EstrogenReceptor/ERR)起作用。(20S)-Protopanaxatriol同时也是LXRα的抑制剂。(20S)-ProtoIC50&Target Glucocorticoidreceptor,Oestrogenreceptor[1];LXRα[2]REFERENCESLeungKW,etal.Protopanaxadiolandprotopanaxatriolbindtoglucocorticoidandoestrogenreceptorsinendothelialcells.BrJPharmacol.2009Feb;156(4):626-37.OhGS,etal.20(S)-protopanaxatriolinhibitsliverXreceptorα-mediatedexpressionoflipogenicgenesinhepatocytes.JPharmacolSci.2015Jun;128(2):71-7.HuangQ,etal.Co-administrationof20(S)-protopanaxatriol(g-PPT)andEGFR-TKIovercomesEGFR-TKIresistancebydecreasingSCD1inducedlipidaccumulationinnon-smallcelllungcancer.JExpClinCancerRes.2019;38(1):129.Published2019Mar15.ZhangH,etal.20(S)-Protopanaxadiol-InducedApoptosisinMCF-7BreastCancerCellLinethroughtheInhibitionofPI3K/AKT/mTORSignalingPathway.IntJMolSci.2018;19(4):1053.Published2018Apr2.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-589559