Valproic-acid-GMP-Dipropylacetic-acid-GMP-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemEValproicacid(GMP)Cat.No.:HY-10585GCASNo.:99-66-1Synonyms:Dipropylaceticacid(GMP)分子式:C₈H₁₆O₂分子量:144.21作用靶点:Organoid;HDAC;Autophagy;MitochondrialMetabolism;HIV;Notch;Apoptosis;EndogenousMetabolite作用通路:StemCell/Wnt;CellCycle/DNADamage;Epigenetics;Autophagy;MetabolicEnzyme/Protease;Anti-infection;NeuronalSignaling;Apoptosis储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性Valproicacid(GMP)是GMP级别的Valproicacid(HY-10585)。GMP级别的小分子可用做细胞疗法中的辅助试剂。Valproicacid(VPA)是一种具有口服活性的HDAC抑制剂，IC50值为0.5-2mM。Valproicacid抑制HDAC1的活性，(IC50，400μM)，同时可诱导HDAC2的降解。Valproicacid激活Notch1信号并抑制小细胞肺癌(SCLC)细胞的增殖。Valproicacid可用于癫痫、双相情感障碍、代谢疾病、HIV感染和偏头痛等的研究。IC50&TargetHDAC1HDACHDAC2Autophagy400μM(IC50)0.5-2mM(IC50)Mitophagy客户使用本产品发表的科研文献SignalTransductTargetTher.2024Jan22;9(1):24.MilMedRes.2020Nov1;7(1):52.MilMedRes.2020Sep6;7(1):42.AdvSci(Weinh).2023Dec12:e2305620.Biomaterials.2018Dec6;193:30-46.1/2 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemESeemorecustomervalidationsonwww.MedChemEREFERENCESHanBR,etal.ValproicacidinhibitsthegrowthofHeLacervicalcancercellsviacaspase-dependentapoptosis.OncolRep.2013Dec;30(6):2999-3005.ZhangZH,etal.ValproicacidinhibitstumorangiogenesisinmicetransplantedwithKasumi1leukemiacells.MolMedRep.2013Nov28.CohenOS,etal.Acuteprenatalexposuretoamoderatedoseofvalproicacidincreasessocialbehaviorandaltersgeneexpressioninrats.IntJDevNeurosci.2013Dec;31(8):740-50.Valproicacid,etal.Histonedeacetylaseisadirecttargetofvalproicacid,apotentanticonvulsant,moodstabilizer,andteratogen.JBiolChem.2001Sep28;276(39):36734-41.AveryLB,etal.ValproicAcidIsaNovelActivatorofAMP-ActivatedProteinKinaseandDecreasesLiverMass,HepaticFatAccumulation,andSerumGlucoseinObeseMice.MolPharmacol.2014Jan;85(1):1-10.PlattaCS,etal.ValproicacidinducesNotch1signalinginsmallcelllungcancercells.JSurgRes.2008Jul;148(1):31-7.RoutyJP,etal.ValproicacidinassociationwithhighlyactiveantiretroviraltherapyforreducingsystemicHIV-1reservoirs:resultsfromamulticentrerandomizedclinicalstudy.HIVMed.2012May;13(5):291-6.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forrese