PARP7-IN-16-free-base-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEPARP7-IN-16freebaseCat.No.:HY-156419ACASNo.:2136325-05-6分⼦式:C₂₅H₂₇FN₄O₄分⼦量:466.5作⽤靶点:PARP作⽤通路:CellCycle/DNADamage;Epigenetics储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:33.33mg/mL(71.45mM;ultrasonicandwarmingandheatto60°C)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.1436mL10.7181mL21.4362mL5mM0.4287mL2.1436mL4.2872mL10mM0.2144mL1.0718mL2.1436mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.5mg/mL(5.36mM);Clearsolution1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.5mg/mL(5.36mM);Clearsolution3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(5.36mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性PARP7-IN-16freebasePARP7-IN-16(HY-156419)的游离态形式。PARP7-IN-16freebase选择性和具有⼝服活性的PARP-1/2/7抑制剂，IC50值分别为0.94，0.87和0.21nM。PARP7-IN-16可⽤于乳腺癌和前列腺癌的研究。IC50&TargetPARP7PARP2PARP10.21nM(IC50)0.87nM(IC50)0.94nM(IC50)REFERENCES[1].ZhouJ,et,al.DiscoveryofQuinazoline-2,4(1H,3H)-dioneDerivativesContainingaPiperizinoneMoietyasPotentPARP-1/2Inhibitors─Design,Synthesis,InVivoAntitumorActivity,andX-rayCrystalStructureAnalysis.JMedChem.2023Oct26;66(20):14095-14115.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;