Moexipril-hydrochloride-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEMoexiprilhydrochloride(Standard)Cat.No.:HY-B0378ARCASNo.:82586-52-5分⼦式:C₂₇H₃₅ClN₂O₇分⼦量:535.03作⽤靶点:Angiotensin-convertingEnzyme(ACE);Apoptosis作⽤通路:MetabolicEnzyme/Protease;Apoptosis储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Moexipril(hydrochloride)(Standard)Moexipril(hydrochloride)的分析标准品。本产品⽤于研究及分析应⽤。Moexiprilhydrochloride(RS-10085)⼀种具有⼝服活性的⾎管紧张素转换酶(ACE)抑制剂，经⽔解为moexiprilat⽽发挥活性。Moexiprilhydrochloride具有降压和神经保护作⽤。IC50&TargetIC50:2.1nM(purifiedACEfromrabbitlung),1.75nM(ACEinratplasma)[3]REFERENCES[1].Chrysant,S.G.andG.S.Chrysant,Pharmacologicalandclinicalprofileofmoexipril:aconcisereview.JClinPharmacol,2004.44(8):p.827-36.[2].Edling,O.,etal.,Moexipril,anewangiotensin-convertingenzyme(ACE)inhibitor:pharmacologicalcharacterizationandcomparisonwithenalapril.JPharmacolExpTher,1995.275(2):p.854-63.[3].FrieheH,etal.Pharmacologicalandtoxicologicalstudiesofthenewangiotensinconvertingenzymeinhibitormoexiprilhydrochloride.Arzneimittelforschung.1997Feb.47(2):132-44.[4].RavatiA,etal.Enalaprilandmoexiprilprotectfromfreeradical-inducedneuronaldamageinvitroandreduceischemicbraininjuryinmiceandrats.EurJPharmacol.1999May28;373(1):21-33.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792a