Mepyramine-maleate-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemEMepyraminemaleate(Standard)Cat.No.:HY-B1281RCASNo.:59-33-6分子式:C₂₁H₂₇N₃O₅分子量:401.46作用靶点:HistamineReceptor作用通路:GPCR/GProtein;Immunology/Inflammation;NeuronalSignaling储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性Mepyraminemaleate(Standard)是Mepyraminemaleate的分析标准品。本产品用于研究及分析应用。Mepyraminemaleate是第一代抗组胺剂，为histamineH1受体拮抗剂，对H1，H2和H3受体的Kd值分别为0.8nM，5200nM和>3000nM，对H1受体的pKd值为9.4。IC50&TargetKd:0.8nM(HistamineH1receptor),5200nM(HistamineH2receptor),>3000nM(HistamineH3receptor)[1]pKd:9.4(HistamineH1receptor)[2]REFERENCESHillSJ.Distribution,properties,andfunctionalcharacteristicsofthreeclassesofhistaminereceptor.PharmacolRev.1990Mar;42(1):45-83.vanderGootH1,etal.Selectiveligandsastoolstostudyhistaminereceptors.EurJMedChem.2000Jan;35(1):5-20.FitzsimonsCP,etal.Mepyramine,ahistamineH1receptorinverseagonist,bindspreferentiallytoaGprotein-coupledformofthereceptorandsequestersGprotein.JBiolChem.2004Aug13;279(33):34431-9.MojtahedinA,etal.Effectsofmepyramineandfamotidineonthephysostigmine-inducedantinociceptionintheformalintestinrats.PakJBiolSci.2008Nov15;11(22):2573-8.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792Fax: