Tacalcitol-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemETacalcitol(Standard)Cat.No.:HY-32337RCASNo.:57333-96-7分⼦式:C₂₇H₄₄O₃分⼦量:416.64作⽤靶点:VD/VDR作⽤通路:VitaminDRelated/NuclearReceptor储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Tacalcitol(Standard)Tacalcitol的分析标准品。本产品⽤于研究及分析应⽤。Tacalcitol(1,24(R)-DihydroxyvitaminD3;1.alpha.,24R-DihydroxyvitaminD3)能通过调节钙离⼦促进正常⾻⽣长。REFERENCES[1].MasuoMorisaki,aoyukiKoizumi,NobuoIkekawaetal.SynthesisofactiveformsofvitaminD.PartIX.Synthesisof1α,24-dihydroxycholecalciferol.J.Chem.Soc.,PerkinTrans.1,1975,1421-1424[2].KiyoshigeOchi,IsaoMatsunaga,HiroyukiNaganoetal.SyntheticstudiesofvitaminD3analoguesfrombileacids.Part3.Synthesesof1α,25-,1α,24R-,and1α,24S-dihydroxycholecalciferolsfromlithocholicacidandtheirbiologicalactivities.J.Chem.Soc.PerkinTrans.1,1979,165-169[3].Rostowska-NadolskaetalVitaminDderivatives:calcitriolandtacalcitolinhibitsinterleukin-6andinterleukin-8expressioninhumannasalpolypfibroblasts.Adv.Med.Sci.(2010)5586.[4].OisoN,KawadaA.FrecklingPromotedbyTopicalTacalcitolinaJapaneseBoywithLeftEyelidVitiligo.PediatrDermatol.2011Oct20.[5].KobayashiT,OkumuraH,AzumaY,KiyokiM,MatsumotoK,HashimotoK,YoshikawaK.1alpha,24R-dihydroxyvitaminD3hasanabilitycomparabletothatof1alpha,25-dihydroxyvitaminD3toinducekeratinocytedifferentiation.JDermatol.1990Nov;17(11):707-9.[6].MatsumotoK,HashimotoK,KiyokiM,YamamotoM,YoshikawaK.Effectof1,24R-dihydroxyvitaminD3onthegrowthofhumankeratinocytes.JDermatol.1990Feb;17(2):97-103.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;