干细胞培养细胞因子研究手册

干细胞培养细胞因子研究手册干细胞培养细胞因子研究手册干细胞概述干细胞培养细胞因子产品目录010308020610间充质干细胞（MSC）胚胎和诱导多能干细胞（ESC/iPSC）造血干细胞（HSC）神经干细胞（NSC）不同细胞因子对MSC的作用应用案例MSC细胞因子推荐

MSC鉴定试剂盒ESC/iPSC细胞因子推荐产品验证数据HSC细胞因子推荐产品验证数据NSC细胞因子推荐产品验证数据北京义翘神州科技股份有限公司01干细胞培养细胞因子研究手册全能干细胞卵裂球胚胎干细胞间充质干细胞骨生成软骨生成肌生成肌肉软骨骨分化和成熟其它例：骨髓、脂肪和皮肤髓质淋巴细胞红细胞白细胞血小板B细胞T细胞神经元星形胶质细胞少突胶质细胞NK细胞造血干细胞神经干细胞诱导多能干细胞多能干细胞专能干细胞体细胞重编程因子(c-Myc、Klf4、Oct4和Sox2）单能干细胞简介干细胞是一类具有自我更新、自我复制和分化成多种细胞系能力的多潜能细胞，包括间充质干细胞、造血干细胞、神经干细胞、胚胎和诱导多能干细胞等。近年来，各种类型的干细胞在疾病治疗方面已取得了重大进展，尤其在治疗癌症、心脏病、糖尿病、克罗恩病等疾病方面具有潜在的应用价值。细胞因子在干细胞研究中发挥着不可或缺的作用，表现在：细胞因子可以控制干细胞的增殖和分化。如：Activin

A能够促进诱导多能干细胞向内胚层分化。细胞因子对干细胞的迁移定位，具有靶向调控作用。如：损伤或炎症处的免疫细胞所分泌的TNF-α和BMP-4等细胞因子，可以促进间充质干细胞对损伤处的定位与迁移，从而促进损伤的组织细胞的修复。更多其他作用。EGF被证明能够提高来自胚胎大脑的神经干细胞的存活率，LIF能够调节干细胞多能性，FGF2也已被确定为多种干细胞类型的关键调节因子。干细胞分化图谱干细胞概述北京义翘神州科技股份有限公司02干细胞培养细胞因子研究手册DEPARTMENT

OF

HEALTH

AND

HUMAN

SERVICESFood

and

Drug

Administration

Silver

Spring,

MD

20993DMF035978DMF

ACKNOWLEDGEMENTSINO

BIOLOGICAL,

INC.Attention:

ZHIQIANG

ZHANBUILDING

9,

JING

DONGHEI

TECHNOLOGY

PARKNO.

18

KECHUANG

10TH

ST,

BDA,

BEIJING,

100176,

CHINADear

ZhiqiangZhan,TheFoodandDrugAdministrationacknowledgesreceiptofthefollowingDrugMaster

File(DMF)submission:DMF

NUMBER

ASSIGNED:

035978DATEOF

SUBMISSION:

MAY

27,

2021DMF

TYPE:

IISUBJECT

(TITLE):

SUPERNUCLEASEHOLDER:

SINO

BIOLOGICAL,

INC.SUBMITTED

BY:

SINO

BIOLOGICAL,

INC.AGENT:

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party

(authorized

party)

or

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toreferencetheDMFandforFDAtoreviewthe

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thatparty

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the

DMF.Anychange,additionordeletionofinformationAnnual

Reports

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DMFcontaining:Reference

ID:

4802568ISO

9001:2015认证2024年值得关注的生长因子供应商ISO

13485:2016认证GMP认证ISO

17025:2017证书FDA

DMF备案作为全球重组技术的领导者，义翘神州开发了一系列高品质干细胞培养重组细胞因子，包括EGF、PDGF-BB、TGF

beta

1、SCF、IGF1和

basic

FGF/FGF2等，具有高纯度、高生物活性、低内毒素和高批间一致性等特点，涵盖研究级和GMP级。此外，我们还提供干细胞标志物抗体和鉴定试剂盒等产品，全面支持多种类型干细胞的研究。高纯度：纯度>95%（SDS-PAGE、HPLC检测）高生物活性：经ELISA、cell-based

assays验证

低内毒素：

5-10

EU/mg高批间一致性种类齐全：涵盖研究级和GMP级细胞因子质量控制：通过ISO

9001/ISO

13485/GMP等多重质量体系认证产品优势资质证书干细胞培养细胞因子产品03干细胞培养细胞因子研究手册细胞因子功能产品推荐basic

FGF/FGF2提高MSC的增殖支持软骨细胞的增殖和分化GMP-10014-HNAEEGF刺激MSC的增殖，但不改变MSC分化潜能增强MSC的旁分泌和自分泌功能GMP-10605-HNAEPDGF-BB促进MSC的增殖与存活促进肌细胞增殖10572-HNAETGFbeta

1促进MSC的增殖促进MSC向软骨细胞分化10804-HNACIGF-1促进MSC的增殖诱导MSC向软骨细胞分化10598-HNAESCF促进MSC的增殖10451-HNAEVEGF-A促进MSC的增殖与存活参与血管内皮细胞的形成、增殖与存活10008-HNAH间充质干细胞（Mesenchymal

stem

cells,

MSC）是一类存在于多种组织（如脐带、骨髓和脂肪组织等），具有自我更新和分化能力的成体干细胞。研究表明，间充质干细胞通过调节与先天性和适应性免疫系统相关的淋巴细胞从而发挥免疫调节和抗炎作用。因此，MSC在自身免疫性疾病、心血管疾病、炎症性疾病、神经退行性疾病等多种疾病治疗中具有重要作用。间充质干细胞因其获取便捷、遗传稳定性高、免疫原性低以及具有组织修复和免疫调节功能的治疗特性，在疾病治疗领域具有广阔的应用前景。不同细胞因子对MSC的作用间充质干细胞培养血管生成骨生成软骨生成脂肪生成肌肉生成内皮细胞成骨细胞 软骨细胞 脂肪细胞参与间充质干细胞分化的细胞因子示意图肌细胞MSCTGF-β

FGF-2

PDGF

EGF祖细胞池BMP2

BMP4

BMP5

FGF2

IGF-1TGF-βWntsBMP2

BMP4

FGF2

IGF-1TGF-βVEGFBMP2

BMP4BMP4

FGF2PDGF-BBGMP级细胞因子，现货供应北京义翘神州科技股份有限公司北京义翘神州科技股份有限公司04干细胞培养细胞因子研究手册细胞因子货号种属表达宿主纯度内毒素basicFGF/FGF210014-HNAEHumanE.

coli≥

95%

SDS<

10

EU/mgGMP-10014-HNAEHumanE.

coli≥

95%

SDS<

10

EU/mgEGF10605-HNAEHumanE.

coli≥

95%

SDS≥

95%

SEC-HPLC<

5

EU/mgGMP-10605-HNAEHumanE.

coli≥

95%

SDS≥

95%

SEC-HPLC<

5

EU/mgPDGF-BB10572-HNAEHumanE.

coli≥

95%

SDS≥

95%

SEC-HPLC<

50

EU/mgTGFbeta

110804-HNACHuman,

Rhesus,Cynomolgus,

CanineCHO

Stable

Cells95%

SDS-PAGE<

1

EU/µg10804-H08HHumanHEK293Cells95%

SDS-PAGE<

1

EU/µgSCF10451-HNAEHumanE.

coli≥

95%

SDS≥

95%

SEC-HPLC<

10

EU/mgGMP-10451-HNAE1-L-AFHumanE.

coli≥

95%

SDS≥

95%

SEC-HPLC<

10

EU/mgVEGF-A10008-HNAHHumanHEK293Cells95%

SDS95%

SEC-HPLC<

1

EU/µgBMP-210426-HNAE1Human,

Mouse,

Rat,Rhesus,

CanineE.

coli≥

95%

SDS<

10

EU/mgBMP410609-HNAE2HumanE.

coli≥

95%

SDS<

1

EU/µgTransdifferentiationEGF

(20

ng/mL)bFGF(10

ng/mL)HepaticinductionHGF

(20

ng/mL)bFGF(10

ng/mL)NTA

(0.61

g/L)MaturationOSM

(20

ng/mL)Dexa

(1

umol/L)ITX

(1

X)2

days1week(a)1weekD1D7D14IAR2025

m间充质干细胞分化为肝样细胞更多MSC培养细胞因子推荐骨髓间充质干细胞的增殖MSC培养细胞因子应用案例GMP级细胞因子，现货供应用到的产品：

EGF、bFGF、HGF（a）体外诱导间充质干细胞分化为肝样细胞流程图（b）间充质干细胞向肝样细胞分化的形态图。DOI:

10.1155/2023/6890299P0为原代细胞，P1、P2、P3分别代表第1、2、3代细胞。

DOI:

10.1186/s12974-022-02393-2用到的产品：EGF（Cat#:

50482-MNCH）、FGF-18（Cat#:

50177-M08H）无动物源细胞因子北京义翘神州科技股份有限公司05干细胞培养细胞因子研究手册NormalizedToModeNormalizedToModeNormalizedToMode100

100

10080

80

8060

60

6040

40

4020

20

200

0

0100

101

102

103

104

100

101

102

103

104

100

101

102

103

104FITC

NegativeCocktail

PE

CD73

PerCP

CD90NormalizedToMode100

101NormalizedToMode102

103

104

100

101APC

CD105102

103

104FITC

CD44NormalizedToMode0

0

0100

101102APC

CD166103

104CD

E100

100

10080

80

8060

60

6040

40

4020

20

20F人间充质干细胞鉴定试剂盒（Cat#:

HMSC07）分析间充质干细胞流式结果图A

B目前，MSC的鉴定方法主要有三种：形态学观察细胞是否呈贴壁状态、多向分化潜能鉴定和MSC表面标志物鉴定。2006年，国际细胞治疗学会（ISCT）提出了一种细胞表面标记物组合，用于鉴定人类间充质干细胞。根据该建议，MSC的细胞表面标志物CD73、CD90和CD105应呈阳性，而CD34、CD45、CD11b或CD14、CD19或CD79α和HLA-DR呈阴性。Cultured

hMSCs

from

umbilical

cord

are

analyzed

by

HMSC07.

Cells

demonstrate

negative

expression

of

CD45,

CD34,

CD14,

CD19,HLA-DR(figure

A)

as

well

as

positive

expression

of

CD73

(Figure

B),

CD90

(Figure

C),

CD105

(Figure

D),

CD44

(Figure

E),

CD166(Figure

F).

The

blue

linesarecells

withisotypeantibodies.

The

redlines

arecellswith

antibodiestargetingto

marker.人间充质干细胞鉴定试剂盒推荐义翘神州提供两款人MSC鉴定试剂盒Cat#:

HMSC03

Cat#:

HMSC07其中HMSC03

试剂盒覆盖所有8个抗体的检测，HMSC07试剂盒又在此基础上添加了CD44和CD166的检测，表面标志物覆盖全面。北京义翘神州科技股份有限公司06干细胞培养细胞因子研究手册参与胚胎和诱导多能干细胞分化的细胞因子示意图胚胎和诱导多能干细胞培养内胚层VEGFEGFFGF2FGF4BMP4TGFbetaHGHVEGFFGF2BMP4VEGFFGF2EGFSCFEGFBMP4FGF2EGFBMP4FGF2VEGFFGF2TGFbetaSCFIL-3IL-6IL-11VEGFBMP4定型内胚层内皮细胞角质细胞表皮细胞神经祖细胞星形胶质细胞皮层神经元神经嵴干细胞少突细胞间充质干细胞/前体细胞骨骼成肌细胞平滑肌细胞造血祖细胞红细胞生成细胞淋巴样祖细胞单核细胞/巨噬细胞祖细胞后肠内胚层肠组织肝细胞多能性肺祖细胞中胚层多能干细胞（ESC/iPSC）外胚层生殖细胞类外胚层细胞精子类卵母细胞+类卵泡结构胚胎干细胞（Embryonic

stem

cell,ESC）和诱导性多能干细胞（Induced

pluripotent

stem

cells,iPSC）均属于多能干细胞，具有无限的自我更新能力，能够分化成任何类型的细胞。ESC是目前最广为人知的多能干细胞，但由于其来源于人类胚胎，潜在的伦理问题成为限制其广泛使用的一大因素。iPSC是从成熟的体细胞转化而来，其特性与胚胎干细胞十分相似，具备无限的自我更新和分化能力，在再生医学、疾病建模、药物测试和创新的细胞/基因疗法方面拥有巨大的潜力。GM-CSF、ActivinA、DLL4、NOG、TNF-α、IL-2、VEGF、FGF、IL1β和EGF等细胞因子在调控人类iPSCs分化为各种细胞系的生理过程中发挥着重要作用。北京义翘神州科技股份有限公司07干细胞培养细胞因子研究手册ESC/iPSC培养细胞因子推荐产品验证数据展示GMP级细胞因子，现货供应细胞因子货号种属表达宿主纯度内毒素Activin

A10429-HNAHHuman,

Mouse,

Rat,Cynomolgus,

RhesusHEK293Cells≥

95%

SDS≥

95%

SEC-HPLC<

10

EU/mgGMP-10429-HNAHHuman,

Mouse,

Rat,Rhesus,

CanineHEK293Cells≥

95%

SDS≥

95%

SEC-HPLC<

10

EU/mgBMP410609-HNAE2HumanE.

coli≥

95%

SDS<

1

EU/µgEGF10605-HNAEHumanE.

coli≥

95%

SDS≥

95%

SEC-HPLC<

5

EU/mgGMP-10605-HNAEHumanE.

coli≥

95%

SDS≥

95%

SEC-HPLC<

5

EU/mgNoggin10267-HNAHHumanHEK293Cells≥

95%

SDS≥

95%

SEC-HPLC<

10

EU/mgbasic

FGF/FGF210014-HNAEHumanE.

coli≥

95%

SDS<

10

EU/mgGMP-10014-HNAEHumanE.

coli≥

95%

SDS<

10

EU/mgHGF10463-HNASHumanCHO

Stable

Cells≥

95%

SDS≥

95%

SEC-HPLC<

0.01

EU/µgHuman

EGF

Protein

(Cat#:

10605-HNAE)Human

IL3

Protein

(Cat#:

GMP-11858-HNAE)-201E-4

1E-3

0.01

0.1

1 10

100160140120100806040200Proliferation,%Human

EGF

Conc.

(ng/mL)Batch

1Batch

2Batch

3mAU400350300250200150100500kDa

M

11666.245.035.025.018.414.45

10

15

20

25

minHigh-purity:

≥

95

%

as

determinedbySDS-PAGE

&

SEC-HPLC.-200Proliferation,%1E-5

1E-4

1E-3

0.01

0.1 1

10

100

1000Human

IL3Conc.(ng/mL)1600

SinobiologicalBatch11400

SinobiologicalBatch21200

SinobiologicalBatch310008006004002000mAU

14012010080604020011666.245.035.025.018.414.4kDa

M5

10

15

20

25

minHigh-purity:

≥

95

%

as

determinedbySDS-PAGE

&

SEC-HPLC.1E-4

1E-3

0.01

0.1

1 10

100

1000Human

IL3Conc.(ng/mL)Activity-validated:

Cell

proliferation

assay

usingTF-1

human

erythroleukemic

cells120010008006004002000Proliferation,%1400

ED

=0.15-0.75

ng/mL50Human

vascular

organoids

derived

from

iPSCswere

cultured

using

FGF2,

VEGFA,

and

EGF.

Thevascular

organoids

are

indicated

by

redarrows.High

batch-to-batch

consistency:

Cellproliferation

assayusing

Balb/C

3T3

mouseembryonic

fibroblasts.High

batch-to-batch

consistency:

Cellproliferation

assay

using

TF-1

humanerythroleukemic

cells.北京义翘神州科技股份有限公司08干细胞培养细胞因子研究手册细胞因子货号种属表达宿主纯度内毒素Flt3

Ligand/FLT3LG10315-HNAEHumanE.

coli≥

95%

SDS≥

95%

SEC-HPLC<

10

EU/mgGMP-10315-HNAE1-L-AFHumanE.

coli≥

95%

SDS≥

95%

SEC-HPLC<

10

EU/mgGM-CSF/CSF210015-HNAHHumanHEK293Cells≥

95%

SDS≥

95%

SEC-HPLC<

10

EU/mgGMP-10015-HNAHHumanHEK293Cells≥

95%

SDS≥

95%

SEC-HPLC<

5

EU/mgIL-610395-HNAEHumanE.

coli≥

95%

SDS<

10

EU/mgGMP-10395-HNAEHumanE.

coli≥

95%

SDS<

5

EU/mgIL-2110584-HNAEHumanE.

coli≥

95%

SDS≥

95%

SEC-HPLC<

5

EU/mgGMP-10584-HNAEHumanE.

coli≥

95%

SDS≥

95%

SEC-HPLC<

5

EU/mgGMP-10584-HNAE1-L-AFHumanE.

coli≥

95%

SDS≥

95%

SEC-HPLC<

10

EU/mgT细胞参与造血干细胞分化的细胞因子示意图造血干细胞（Hematopoieticstemcells,HSC）是一种具有自我更新能力和多向分化为各类血细胞特性的细胞，包括骨髓系和淋巴系细胞，在维持血液系统的建立和动态平衡中具有极其重要的作用。HSC存在于多种血液系统中，例如外周血、骨髓和脐带血等。造血干细胞可以替代异常的造血组织和免疫组织，是治疗血液恶性肿瘤和肝病等疾病的有力工具。HSC培养细胞因子推荐义翘神州提供大量HSC培养用细胞因子，其中包含多种GMP级细胞因子，全面支持HSC研究。造血干细胞培养GMP级细胞因子，现货供应无动物源细胞因子内胚层巨核细胞B细胞单核细胞嗜中性粒细胞Flt3LSCFTPO

HSC自分化GM-CSFG-CSFIL-6M-CSFGM-CSFIL-7

SCFVCAM-1SCFEPOIL-3ICAM-1VCAM-1Flt3L

IL-7SCFTPOIL-3HSC09干细胞培养细胞因子研究手册产品验证数据展示GMP级细胞因子，现货供应北京义翘神州科技股份有限公司GMP-grade

Human

IFN

gamma(Cat#:

GMP-11725-HNAE)GMP-grade

Human

GM-CSF/CSF2(Cat#:

GMP-10015-HNAH)GMP-grade

Human

IL-6(Cat#:

GMP-10395-HNAE)GMP-grade

Human

IL-21

(Cat#:

GMP-10584-HNAE)GMP-grade

Human

IL-4(Cat#:

GMP-11846-HNAE)GMP-grade

Human

IL-2(Cat#:

GMP-11848-HNAE)Five

tests

were

conducted

at

different

times

toverify

GMP-grade

human

IL-6

stability.Five

cycles

of

freeze-thaw

tests

wereconducted

to

verify

GMP-gradehuman

IL-6

stability.Six

tests

were

conducted

at

differenttimes

to

verify

GMP-grade

human

IL-4stability.0.300.350.400.500.45OD-Blank0.250.1

1

10

100Human

IFN

gamma

Conc.

(pg/mL)Measured

in

anti-viral

assays

usingWISH

cells

infected

with

vesicularstomatitis

virus

(VSV).ED50=8-80

pg/mL01000200030004000Proliferation,%1E-5

1E-4

1E-3

0.01

0.1

1 10

100Human

GM-CSF

Conc.

(ng/mL)Measured

in

a

cell

proliferation

assay

usingTF-1

human

erythroleukemic

cells.ED50=0.06-0.3

ng/mL10Proliferation,%Human

IL-2

Conc.

(ng/mL)Measured

in

a

cell

proliferationassay

using

CTLL2.600

ED50=1-8

ng/mL5004003002001000-1000.1

10.1

1 10

1003002001000-1001E-5

1E-4

1E-3

0.01600500400Proliferation,%Human

IL-6

Conc.

(ng/mL)Measured

in

a

cell

proliferation

assay

usingTF-1

human

erythroleukemic

cells.50ED

=0.1-0.8ng/mL1E-3

0.01

0.1

1

10

10016001400120010008006004002000-200Conc

of

Secretion

IFN-r.(pg/ml)Human

IL-21

Conc.

(ng/mL)Three

and

five

cycles

of

freeze-thaw

tests

wereconducted

to

verify

GMP-grade

human

IL-21

stability.freeze-thaw

0

timesfreeze-thaw

3timesfreeze-thaw

5

times1E-3

0.01

0.1

1

10

100Conc

of

Secretion

IFN-r.(pg/ml)Human

IL-21

Conc.

(ng/mL)Four

tests

were

conducted

at

different

timesto

verify

GMP-grade

human

IL-21

stability.2000

25℃

0

day1800 25℃

16

day1600

25℃

24

day1400

25℃

48

day1200100080060040020001E-5

1E-4

1E-3

0.01

0.1

1

10

1008007006005004003002001000Proliferation,%HumanIL-4

Conc.

(ng/mL)37℃

0

day37℃

7

day37℃

11

day37℃

15

day37℃

18

day37℃

35

day37℃

0

day37℃

7

days37℃

11

days37℃

15

days37℃

18

days10

100-1001E-5

1E-4

1E-3

0.01

0.1

16005004003002001000Proliferation,%Human

IL-6

Conc.

(ng/mL)1E-5

1E-4

1E-3

0.01

0.1

1 10

100

1000150100500200300250Proliferation,%Human

IL-6

Conc.

(ng/mL)Freeze-thaw

0

timeFreeze-thaw

5

times北京义翘神州科技股份有限公司10干细胞培养细胞因子研究手册细胞因子货号种属表达宿主纯度内毒素BDNF50240-M08HMouseHEK293Cells95%

SDS<

1

EU/µgBMP-210426-HNAE1Human,

Mouse,

Rat,Rhesus,

CanineE.

coli≥

95%

SDS<

10

EU/mgEGF10605-HNAEHumanE.

coli≥

95%

SDS≥

95%

SEC-HPLC<

5

EU/mgGMP-10605-HNAEHumanE.

coli≥

95%

SDS≥

95%

SEC-HPLC<

5

EU/mgbasic

FGF/FGF210014-HNAEHumanE.

coli≥

95%

SDS<

10

EU/mgGMP-10014-HNAEHumanE.

coli≥

95%

SDS<

10

EU/mgSonic

Hedgehog/SHH10372-H08H1HumanHEK293Cells95%

SDS<

1

EU/µg参与神经干细胞分化的细胞因子示意图神经干细胞（Neural

stemcell,NSCs）是存在于神经系统中，能进行自我更新，并具有分化为神经元、星形胶质细胞和少突胶质细胞潜能的细胞群，能产生大量脑组织细胞。研究表明，NSC在特定条件下分化为相应的功能细胞，从而替代缺失细胞，恢复原有的功能，在神经发育和修复受损神经组织中发挥重要作用。NSC培养细胞因子推荐神经干细胞培养GMP级细胞因子，现货供应神经干细胞神经元脊髓运动神经元多巴胺能神经元谷氨酸能神经元GABA神经元海马神经元少突细胞星形胶质细胞神经元祖细胞神经胶质祖细胞EGF

FGF2PDGF-BB

VEGFbeta-NGFCNTF

FGF2PDGF-BBEGF

FGF2

CNTF

IGF-1PDGF-BBCNTF

EGFEGFbasic

FGF

FGF-10Sonic

Hedgehog/SHHFGF2PDGF-BBBDNF

CNTF

GDNF

IGF-1BDNF

FGF4

FGF8

SHHBMP2

BMP4

FGF8BDNF

GDNF

IGF-1NT-4

SHHBDNF

IGF-1北京义翘神州科技股份有限公司11干细胞培养细胞因子研究手册产品验证数据展示Human