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“REVISEDRESPONSECRITERIAFORMALIGNANTLYMPHOMA”JClinOncol25:579-586.©2007byAmericanSocietyofClinicalOncologyChesonetal,JClinOncol17:1244,1999 In1999,anInternationalWorkingGroup(IWG)ofclinicians,radiologists,andpathologistswithexpertiseintheevaluationandmanagementofpatientswithLymphomapublishedguidelinesforresponseassessmentandoutcomesmeasurement.ResponseCriteriaforLymphomaReappearanceNeworincreasedNeworincreasedEnlargingliver/spleen;newsitesRelapse/progressionIrrelevant

≥50%decrease

≥50%decreaseDecreaseinliver/spleenIrrelevant

≥50%decrease

≥50%decreaseNormalPositiveNormalNormalNormalPRNormalorindeterminate>75%decreaseNormalNormalIndeterminateNormalNormalNormalCRuNormalNormalNormalNormalCRBoneMarrowLymphNodeMassesLymphNodesPhysicalExaminationResponseCategoryDefinitionsofEndPointsforClinicalTrials

DeathDeathrelatedtoNHLAllpatientsCause-specificdeathEntryontotrialTimewhennewtreatmentisneededAllpatientsTimetonexttreatmentFirstdocumentationofresponseTimetorelapseorprogressionCR,CRu,PRResponsedurationFirstdocumentationofresponseTimetorelapseCR,CRuDisease-freesurvivalEntryontotrialDiseaseprogressionordeathfromNHLAllpatientsProgression-freesurvivalEntryontotrialFailureordeathfromanycauseCR,CRu,PREvent-freesurvivalEntryontotrialDeathfromanycauseAllpatientsOverallsurvivalPointofMeasurementDefinitionResponseCategoryEndPointStandardizedresponsecriteriaprovideuniformendpointsforclinicaltrials:AllowingforcomparisonsamongstudiesFacilitatingtheidentificationofmore effectivetherapiesThewidelyusedIWGcriteriaforresponseassessmentoflymphomaarebasedpredominantlyonCT.

ItbecameclearthattheInternationalWorkingGroupcriteriawarrantedrevision,becauseofidentifiedlimitationsandtheincreaseduseof:[18F]fluorodeoxyglucose-positronemissiontomography(PET),

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