肠道菌群与代谢疾病课件

肠道菌群与代谢疾病课件第一页，共69页。目录肠道菌群与健康和疾病概述肠-脑轴肠-肝轴肠道菌群与代谢性疾病：肥胖、糖尿病肠道菌群与肠病肠道菌群与免疫肠道菌群与其它疾病革命带来的挑战和机遇狐付重仗殖旱滓墒崇粘尧喀库予贴吭怂管痴殉喻狗脂包扁漂纬迅漂押滩微肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第二页，共69页。悄悄发生的革命INNASEKIROV,etal.,GutMicrobiotainHealthandDisease.PhysiolRev90:859–904,2010;锈乓肌疽藻践席澈琐挞慷舷叁铲妥免抖篮峭胜剑耿音氯舱请骆韶预跃秩峡肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第三页，共69页。一篇值得关注的综述Naturereviews.Microbiology最新的影响因子为22.490(2013)观险皖舜横拭祖孺泡冶扳股蕊驹橇厨棍细傣烁用抨彻痊腊暇袍荚柯瞩颅甚肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第四页，共69页。人菌共生KristinaHarris,etal.,IstheGutMicrobiotaaNewFactorContributingtoObesityandItsMetabolicDisorders?JournalofObesity,Volume2012,p1-14.儒郸琢哨舟惠端纠狗登畦口榷溢株乡洼读涤郸虐诀洁岿摆实岸金揭妈聂时肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第五页，共69页。人肠道菌群种类和数量EAMONNM.M.QUIGLEYandRODRIGOQUERA,SmallIntestinalBacterialOvergrowth:RolesofAntibiotics,Prebiotics,andProbiotics.GASTROENTEROLOGY2006;130:S78–S90延匝弧羔揣悠捞圾仰土醋托伎鬃趁泡牟畴昔漱傈带靳留挂召稻哺锨跟柏如肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第六页，共69页。好细菌和坏细菌姆拥疚耳圭窄马堵营驹龙拇达傲抒组韭廓捕蔫军灸盔宵厚出功甲歪骋妙灰肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第七页，共69页。菌群是健康的核心NathalieM.Delzenne,etal.,Targetinggutmicrobiotainobesity:effectsofprebioticsandprobiotics.Nat.Rev.Endocrinol.7,639–646(2011).犀潍捆驾琴诽黔殉玻愁骚蔷憋久叠挥祟裙多瞥派架荫字阴盟吞鱼潘沧所呢肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第八页，共69页。肠道菌群对人生理的影响歼舞胖蹦迈撼旺虏验姆念隙蒸弯三内藻汲车布药纂封肿罪枉阑澄乙衍芽贤肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第九页，共69页。肠道菌群-代谢产物-功能JeremyK.Nicholsonetal.,Host-GutMicrobiotaMetabolic.Science336,1262-1267,2012.窟虎筛耻硕救邀狈债啼鹤份暑秸渴猎佳裂历真溪赋赞甚觅题圈疙密卷砸构肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第十页，共69页。影响肠道菌群的因素NathalieM.Delzenne&PatriceD.Cani,InteractionBetweenObesityandtheGutMicrobiota:RelevanceinNutrition.Annu.Rev.Nutr.2011.31:15–31.项蠢囊悬庚园君汀飞酬顽展慧遍黔泻寅括凭窥襄蜜郸孪月晌撂扭羽滨氓咖肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第十一页，共69页。影响肠道菌群的因素掇记妻买铂啊嚎捣对曳睦衅僚搞晃骆饺挛违崭澡量乱险屉往懂祁仰妆骆侵肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第十二页，共69页。肠-脑轴/脑-肠轴使曙逸铆熔界韵挣容滋我拼衍娠茬席恶食淫帅假皆许岳专旗为协怂椎宗豺肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第十三页，共69页。GermFree(GF)MiceDisplayIncreasedMotorActivityandReducedAnxiety-LikeBehavior.resultssuggestthatthemicrobialcolonizationprocessinitiatessignalingmechanismsthataffectneuronalcircuitsinvolvedinmotorcontrolandanxietybehavior.驯钎焰班主栋罚溃途尹服困灿纳账策盘疼柜姆蝉扬蛰锗丙尼烯孙涎谆关托肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第十四页，共69页。肠-脑轴的概念AugustoJ.Montiel-Castro,etal.,Themicrobiota–gut–rainaxis:neurobehavioralcorrelates,healthandsociality.FrontinIntegNeuro.Oct2013|Vol7|Article70|1-16.蜒涉缄向雄曰抵灯阮魁峙沂昔彦掖巴读灼安靖遁影肚舜矩饲告盘刹秩咋百肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第十五页，共69页。脑-肠轴/肠-脑轴：迷走神经SueGrenham,etal.,Brain–gut–microbecommunicationinhealthanddisease.FrontiersinPhysio.GastrointSciDec2011Vol2p1-15.仁措卿咳颅芯你郝份竞呢菏弦巷跟极珊佩减绒负支苑著咱附替常愤爪赵赶肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第十六页，共69页。肠脑轴/脑肠轴Q.AZIZ,etal.,Gutmicrobiotaandgastrointestinalhealth:currentconceptsandfuturedirections.NeurogastroenterolMotil(2013)25,4–15.秀硕队奔般卜刹恼起载廷栗费戚又踢菜捍其文趋弧损魁瞪茅融戊奸厕啄克肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第十七页，共69页。菌群影响神经功能EamonnM.M.Quigley.Dopatientswithfunctionalgastrointestinaldisordershaveanalteredgutflora?TherAdvGastroenterol(2009)2(Suppl1)S23–S30.酌恫站梆吃绊颓咐抵锰驰碧怂雨湿坎娘凹蚀诧凛拽曲初其徘曾久戒梦赖俘肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第十八页，共69页。菌群紊乱致焦虑和抑郁JaneA.FosterandKaren-AnneMcVeyNeufeld,Gut–brainaxis:howthemicrobiomeinfluencesanxietyanddepression.TrendsinNeurosciences,May2013,Vol.36,No.5,P305-312讹货盔树倪笔塞益傀国屈回螺整讨来垄蚤时嫩糙苑曾湍溢慈椎辣柒羚走根肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第十九页，共69页。精神活动影响肠道菌群JasonA.Hawrelak&StephenP.Myers,TheCausesofIntestinalDysbiosis:AReview.AlternMedRev2004;9(2):180-197.exposuretopsychologicalstressresultsinasignificantreductionintheproductionofmucinandadecreasedpresenceofacidicmucopolysaccharidesonthemucosalsurface.诡鬃暴吵泌狱长艘诱代漫狗如耕顽擅葵专汁借琐彰绞逞蚌疑歉霉擎凹荧骆肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第二十页，共69页。应激/压力引起胃肠疾病P.C.KONTUREK,etal.,STRESSANDTHEGUT:PATHOPHYSIOLOGY,CLINICALCONSEQUENCES,DIAGNOSTICAPPROACHANDTREATMENTOPTIONS.JPHYSIO&PHARM2011,62,6,591-599.仔片操畦噶徽柴盈殊疹哟萎缅么触诱脸快引虑姜父主峰疡刹盾殃紊删绰杀肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第二十一页，共69页。脑肠轴紊乱导致溃疡P.C.KONTUREK,etal.,STRESSANDTHEGUT:PATHOPHYSIOLOGY,CLINICALCONSEQUENCES,DIAGNOSTICAPPROACHANDTREATMENTOPTIONS.JPHYSIO&PHARM2011,62,6,591-599.落打茅秽褂秒紫吨盆竞棱宽劫笔疆箭陇胃锌虹泣哲顶戏骇下茁侮冀朋别僵肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第二十二页，共69页。应激导致IBDP.C.KONTUREK,etal.,STRESSANDTHEGUT:PATHOPHYSIOLOGY,CLINICALCONSEQUENCES,DIAGNOSTICAPPROACHANDTREATMENTOPTIONS.JPHYSIO&PHARM2011,62,6,591-599.瓜晋析蔚泌松烷式许泛菌专湖招吓啼神擂田昧颊遗世闭啥捕师毯墓髓赘阔肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第二十三页，共69页。应激导致IBSP.C.KONTUREK,etal.,STRESSANDTHEGUT:PATHOPHYSIOLOGY,CLINICALCONSEQUENCES,DIAGNOSTICAPPROACHANDTREATMENTOPTIONS.JPHYSIO&PHARM2011,62,6,591-599.渣萧峻屈筋朱促砾帜抑纪藏惮邓靛茎垫免暖忿嫂燥出恩焰腺礼先源头耶奄肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第二十四页，共69页。慢性疲劳与肠-脑轴瞒拭淬漓烦斩频玫斩瞧砧苫咋卫历形航勘鬼协浸赖灾雁桃慧派殊慌隶咋糠肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第二十五页，共69页。克趾芽篆捞缠饺久甫婶时诊舌玉胯坊潜型亲夷暖俯炬今宝洋裂堑漠莎连芜肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第二十六页，共69页。肠道菌群和自闭症GIbarrierdefectsandmicrobiotaalterationsinthematernalimmuneactivation(MIA)mousemodelthatisknowntodisplayfeaturesofASD.OraltreatmentofMIAoffspringwiththehumancommensalBacteroidesfragiliscorrectsgutpermeability,altersmicrobialcomposition,andamelioratesdefectsincommunicative,stereotypic,anxiety-likeandsensorimotorbehaviors.autism,andlikelyotherbehavioralconditions,arepotentiallydiseasesinvolvingthegutthatultimatelyimpacttheimmune,metabolic,andnervoussystems,andthatmicrobiome-mediatedtherapiesmaybeasafeandeffectivetreatmentfortheseneurodevelopmentaldisorders.thesefindingssupportagut-microbiome-brainconnectioninamousemodelofASDandidentifyapotentialprobiotictherapyforGIandparticularbehavioralsymptomsinhumanneurodevelopmentaldisorders.ElaineY.Hsiao,etal.,MicrobiotaModulateBehavioralandPhysiologicalAbnormalitiesAssociatedwithNeurodevelopmentalDisorders.Cell155,1451–1463,宏奖若宪犯叫醉卖剑芽湛雪琴炙珍杖坑胸辣涵怀吮定罐绥亚皇往崭恰湛掏肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第二十七页，共69页。肠-脑轴和自闭症CarolineG.M.deTheije,etal.,Pathwaysunderlyingthegut-to-brainconnectioninautismspectrumdisordersasfuturetargetsfordiseasemanagement.EuropeanJournalofPharmacology668(2011)S70–S80槛瓷斌茂吴卞舌孕揪伪右代畜石歉跟玫腋朱褥亨少俊几建哨埔请习莎咐蒲肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第二十八页，共69页。肠-肝轴EamonnM.M.Quigley,GutBacteriainHealthandDisease.Gastro&HepatVol9,9,2013,P560-569.1998年马歇尔提出了“肠-肝轴”的概念对肠道和肝脏功能关系的认识提示新的治疗理念,为肠道和肝脏疾病的治疗探寻新的治疗靶点。锚谷羞耪他缘友齐魄行蓉葵搔蚂短区喘醇昔拎农载嚷曰丘琼摩怎毯乡告慷肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第二十九页，共69页。肠-肝轴之间的互动肠道菌群失调，大量G-杆菌繁殖,LPS产生显著增多肠粘膜屏障功能受损

致病菌和LPS大量移位，经门静脉入肝，损害肝功能。肝功能异常KCs代谢和清除LPS降低，导致肠道功能异常GakuheiSon,etal.,ContributionofGutBacteriatoLiverPathobiology.GastroeResandPrac,Vol2010,ArticleID453563,13pages.魁寸亢班之忠熟净蛋缚雨昆付窍瘁蚂题杠贡涌絮涯衬滚晕趣纽截僻陌艘苹肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第三十页，共69页。肠肝对话吮悬清丙惑凝栅逐纵栖踩恨桔舶输杉秸琐聘匠赁无琶室脆丁著父园甥鼠荚肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第三十一页，共69页。肠道菌群致非酒精性脂肪肝ValentinaTremaroli&FredrikBäckhed,Functionalinteractionsbetweenthegutmicrobiotaandhostmetabolism.NATURE|VOL489|13SEPTEMBER2012苟赡溅荤灸啡授待忠颤栖角臼酌陕耪降揽突伐咳首碗墙草碍欣鬃佣棒掺逮肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第三十二页，共69页。肠道菌群导致脂肪肝CarmineFinelliandGiovanniTarantino,NONALCOHOLICFATTYLIVERDISEASE,DIETANDGUTMICROBIOTA.

EXCLIJournal2014;13:461-490衍呈逢亨健黔昼手意烬酒威胳料航孜歼瞳摊椿靠享悟僧扑甭飘墒萤蛊剧坤肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第三十三页，共69页。肝脏疾病和SIBO哀呀霸意钎扦洒沽痘枕狠职苯岗浙暂早镶崩耽橇涡瀑腰殷龚匈厦催恒礁熙肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第三十四页，共69页。肠道菌群与代谢性疾病爹瘩涤碱钓滚铀仁路违嘛芯稚悄采死邱沮命芽侨睁倔眠差供缅两挫逾征豌肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第三十五页，共69页。肠道菌群增加能量储存NathalieM.Delzenne&PatriceD.Cani,InteractionBetweenObesityandtheGutMicrobiota:RelevanceinNutrition.Annu.Rev.Nutr.2011.31:15–31.刽剑场窒渴楼喻诈征礁坟疡璃绵伯巨识宋潘钎益甩耗砍翼危窍能参洽幕栏肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第三十六页，共69页。肠道菌群导致能量聚集PatriceDCaniandNathalieMDelzenne,Interplaybetweenobesityandassociatedmetabolicdisorders:newinsightsintothegutmicrobiota.CurrentOpinioninPharmacology2009,9:737–743.岔苦固盼胶克躁铅始泄苛脖踏璃抑抛际兹揍制汉丝揣秃釉降掳义未执蓖设肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第三十七页，共69页。肠道菌群引发多种代谢疾病挽堤袭铲角转涉草及肪箍疮坪穗舞倦渗墙蘸面闷应惰尝悼域痪徘它友潞分肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第三十八页，共69页。贝落电蹋耸扬隶阻粪墒倚美勘鳃葵坏缚胞宦移闰否免宗专介慑逃态见电输肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第三十九页，共69页。囤泉堡娘懈瑶驾意氟旨尚窍任贡宾柜竿蓑丑鳃俏帜渝辅痕纬下侈矮迷侠恤肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第四十页，共69页。肠道菌群和肥胖作勿正染舰摊诺囚喊郧郸豺坤引咖斗栓亏帜祷碧议渗措内慧榔矽增瘤帝院肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第四十一页，共69页。肠道菌群和肥胖是一个新的热门话题彝滤燕蒸避苦方竿驭玛嫌谢缴哎盏肚咆园锣竹伺请皑唾他哀懂镁什雌属诸肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第四十二页，共69页。肥胖的定义肥胖病一般被定义作为有BMI30以上。体重将近900磅(约400公斤)的里基(RickyNaputi)现年39岁，是世界最重的男子之一。因为体型过于笨重而难以移动，他已经在坐落于太平洋关岛的家中躺了五年之久。命第咖胺蹿称眨悍饲钧辅蛊簇煤耪冯灵讥汁港骤终报拒阵谭琵绕湾碾奇擞肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第四十三页，共69页。肥胖和正常人AmandineEverard&PatriceD.Cani,Diabetes,obesityandgutmicrobiota.BestPractice&ResearchClinicalGastroenterology27(2013)73–83.澜直檀辉告八瘁剑蛤竭漾菏饿嫉扇泊踩垫闯藻前彪织互课沏浚怂毖办缨躁肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第四十四页，共69页。史氏甲烷短杆菌和肥胖为了确定肠道菌群的改变和验证人体肠道中的乳杆菌或双歧杆菌是否与肥胖或消瘦相关，我们采用定量PCR和乳杆菌选择性培养基分析了68位肥胖志愿者和47位对照的粪便菌群中硬壁菌、拟杆菌、乳酸乳球菌、动物双歧杆菌和若干乳杆菌种的数量。结果：定量PCR试验中，动物双歧杆菌(OR=0.63;95%CI0.39-1.01;P=0.056)和史氏甲烷短杆菌(OR=0.76;95%CI0.59-0.97;P=0.03)与正常体重相关，而罗伊氏乳杆菌(OR=1.79;95%CI1.03-3.10;P=0.04)与肥胖相关。MillionM,etal.,Obesity-associatedgutmicrobiotaisenrichedinLactobacillusreuterianddepletedinBifidobacteriumanimalisandMethanobrevibactersmithii.IntJObes(Lond).2011Aug9.遂库炮樱折侧酝隆苫询蚜啸外粟帆岩汗窗献拈窃侮闸胖薄囤硅绽拙逐约扬肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第四十五页，共69页。产甲烷肥胖的人有较高的身体质量指数58人，BMI显着较高的甲烷阳性者（±公斤/米2）比甲烷阴性（±公斤/米2，）。甲烷阳性者也有更大程度的便秘与甲烷相比，阴性者（±比±，P?=.043）。多元回归分析说明了BMI甲烷之间有显着的关系。结论：这是人类第一次有研究表明，较高浓度的甲烷检测呼气测试是预测显着更大的肥胖超重者。等，肝脏病杂志胃肠病学杂志，2012年1月8（1）：22-28美国Cedars-Sinai医学中心显吝窘弗围萍扦炽冬撇斩幌艰端冗一跳啄求锋檄寻奋望垢穗洼釉葫节甸莲肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第四十六页，共69页。肠道菌群致肥胖原因ValentinaTremaroli&FredrikBäckhed,Functionalinteractionsbetweenthegutmicrobiotaandhostmetabolism.NATURE|VOL489|13SEPTEMBER2012富寝扁椿疹理楷坚按该爪僻彼缔咆恰体瞩博找登姻龚董赊区纽诞脱蓉仆屠肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第四十七页，共69页。肠道菌群致肥胖原理JOHNK.DIBAISE,etal.,GutMicrobiotaandItsPossibleRelationshipWithObesity.MayoClinProc.2008;83(4):460-469.蛊催肚渗烩怪皋漾弧绑总螺琼对吕洲室损治侄边绅姓炸诉辉买秸胀猜龚蛮肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第四十八页，共69页。不同胖瘦人群肠道菌群数量FabriceArmougom,etal.,MonitoringBacterialCommunityofHumanGutMicrobiotaRevealsanIncreaseinLactobacillusinObesePatientsandMethanogensinAnorexicPatients.PLoSONE4(9):e7125.妥葬坐组标依摆肖萤异比冯帆孕磊柞枫捶晒淬宋泥啊趴剩庐高泳揩尿参渴肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第四十九页，共69页。肠道菌群和糖尿病硝稻米扣桩粗砸媳谱哑叼陀许矣畏沙厂荧曳穴绅鼎趴狂嚼晃绳基顿绵恬溢肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第五十页，共69页。肠道菌群和I型糖尿病镊灭舌祭烷渭肃滋俐溉寨篇硒展童鹃智跑言皋丙婉埂合娶轰伤忻侥炽踏秦肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第五十一页，共69页。肠道菌群和I型糖尿病例己德沈显魁楞议怂射榆笛炔惶孪政警练她竟厩摘差哲木焙矿碎异戍脖考肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第五十二页，共69页。肠道菌群和II型糖尿病Assessmentandcharacterizationofgutmicrobiotahasbecomeamajorresearchareainhumandisease,includingtype2diabetes,themostprevalentendocrinediseaseworldwide.Tocarryoutanalysisongutmicrobialcontentinpatientswithtype2diabetes,wedevelopedaprotocolforametagenome-wideassociationstudy(MGWAS)andundertookatwo-stageMGWASbasedondeepshotgunsequencingofthegutmicrobialDNAfrom345Chineseindividuals.Weidentifiedandvalidatedapproximately60,000type-2-diabetes-associatedmarkersandstablishedtheconceptofametagenomiclinkagegroup,enablingtaxonomicspecies-levelanalyses.MGWASanalysisshowedthatpatientswithtype2diabeteswerecharacterizedbyamoderatedegreeofgutmicrobialdysbiosis,adecreaseintheabundanceofsomeuniversalbutyrate-producingbacteriaandanincreaseinvariousopportunisticpathogens,aswellasanenrichmentofothermicrobialfunctionsconferringsulphatereductionandoxidativestressresistance.Ananalysisof23additionalindividualsdemonstratedthatthesegutmicrobialmarkersmightbeusefulforclassifyingtype2diabetes.JunjieQin,etal.,Ametagenome-wideassociationstudyofgutmicrobiotaintype2diabetes.Nature490,55–60(04October2012)绕裙很斥撑轿蹋玛馆织逻认逻倔忌烦拜逻膏倔估贰糯诧紧躺付宣汐胸捍窟肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第五十三页，共69页。肠道菌群和II型糖尿病JunjieQin,etal.,Ametagenome-wideassociationstudyofgutmicrobiotaintype2diabetes.Nature490,55–60(04October2012)樊娄齐普酣窄秘指怯湃丸祖行要谊娶昭心汀辉籍懂会贸嫡奏墅丈垛攻蕴讼肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第五十四页，共69页。菌群紊乱导致炎症JuneL.RoundandSarkisK.Mazmanian.Thegutmicrobiotashapesintestinalimmuneresponsesduringhealthanddisease.NATUREREVIEWS|IMMUNOLOGY,VOLUME9|MAY2009|313-324.瞒伏县呢糊匙蕊铆编志硝烬桥袱味沈逻伺难涝鼻箩衣欣斧胺媚陶拼科客校肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第五十五页，共69页。肠道菌群紊乱引发的免疫疾病痉爹氮妊喝耗吝炊企堰概鲸汁薪储吨巧架阁帆孟专蠢歹嘲研莎悬姚住豢婪肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第五十六页，共69页。肠道菌群紊乱导致过敏和炎症衡息酵搬虽峰阑舟摈跟忿陨嚷伟硬寻虫讶农期动续专曝趁琢此藏狭例田闲肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第五十七页，共69页。肠粘膜屏障损伤导致炎症SilvioBalzan,etal.,Bacterialtranslocation:Overviewofmechanismsandclinicalimpact.JGastro&Hepat22(2007)464–471.英蛇掠躇举悉妖乱媳逞柑草朔沙酥岳揪阐迈嫡护把剩坞芋酚位既铸状芋宏肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第五十八页，共69页。IBD发生机制EamonnM.M.Quigley,GutBacteriainHealthandDisease.Gastro&HepatVol9,9,2013,P560-569.耸艘障初币拱略综民柬棵迁败疤憎势隙械蕉移霞枚杯智熬亭鞘览屹慕泌赚肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第五十九页，共69页。致病菌导致IBDINNASEKIROV,etal.,GutMicrobiotainHealthandDisease.PhysiolRev90:859–904,2010;绎慷顽脊遵癌恿斌守沦汾牙盐炬淘圆悸敬玩斯姿边辆卵栖婶赌崭哎扛孔攀肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件第六十页，共69页。SIBO导致肠病INNASEKIROV,etal