NUC-7738-DataSheet-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemENUC-7738Cat.No.:HY-136506CASNo.:2348493-39-8分⼦式:C₂₆H₂₉N₆O₇P分⼦量:568.52作⽤靶点:Others作⽤通路:Others储存⽅式:Powder-20°C3yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:100mg/mL(175.90mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.7590mL8.7948mL17.5895mL5mM0.3518mL1.7590mL3.5179mL10mM0.1759mL0.8795mL1.7590mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.5mg/mL(4.40mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%cornoil1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemESolubility:≥2.5mg/mL(4.40mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性NUC-77383'-脱氧腺苷的芳氧氨磷酸酯，3'-脱氧腺苷(3'-dA)的5'-芳氧氨磷酸酯前药。NUC-7738对⼀组⾎液癌细胞系具有有效的细胞毒活性。NUC-7738可⽤于癌症研究。体外研究NUC-7738(compound7a;0-198μM;72h;CCRF-CEM,HL-60,KG-1,MOLT-4,K562,MV4-11,THP-1,HEL92,NCI-H929,RPMI-8226,Jurkat,Z138,RL,HS445,HepG2,MCF-7,Bx-PC-3,HT29,MIAPaCa-2andSW620cells)hasanticanceractivityandcytotoxicactivityagainstalineageofleukocyteswithLC50valuesof＜30μM[1].NUC-7738(1μM)hasgoodstabilityinhumanhepatocyteswitht1/2valueof48.1min[1].NUC-7738hasincreasedstabilityinhumanplasmacomparedtotheparentnucleoside,withnochangeinplasmaconcentrationupto4h[1].REFERENCES[1].SerpiM,et,al.SynthesisandCharacterizationofNUC-7738,anAryloxyPhosphoramidateof3'-Deoxyadenosine,asaPotentialAnticancerAgent.JMedChem.2022Dec8;65(23):15789-15804.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-82