D-Lin-MC3-DMA-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemED-Lin-MC3-DMACat.No.:HY-112251CASNo.:1224606-06-7分⼦式:C₄₃H₇₉NO₂分⼦量:642.09作⽤靶点:Others作⽤通路:Others储存⽅式:Pureform-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:100mg/mL(155.74mM;Needultrasonic)Ethanol:100mg/mL(155.74mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.5574mL7.7871mL15.5741mL5mM0.3115mL1.5574mL3.1148mL10mM0.1557mL0.7787mL1.5574mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%saline1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemESolubility:≥2.5mg/mL(3.89mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:2.5mg/mL(3.89mM);Suspendedsolution;Needultrasonic3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(3.89mM);Clearsolution4.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(3.89mM);Clearsolution5.请依序添加每种溶剂：10%DMSO>>90%salineSolubility:6.25mg/mL(9.73mM);Suspendedsolution;Needultrasonic6.请依序添加每种溶剂：5%DMSO>>40%PEG300>>5%Tween-80>>50%salineSolubility:5mg/mL(7.79mM);Suspendedsolution;Needultrasonic7.请依序添加每种溶剂：5%DMSO>>95%(20%SBE-β-CDinsaline)Solubility:5mg/mL(7.79mM);Suspendedsolution;NeedultrasonicBIOLOGICALACTIVITY⽣物活性D-Lin-MC3-DMA⼀种可电离的阳离⼦脂质,⼀种有效的递送siRNA载体。体内研究Lipidnanoparticles(LNPs)containingdistearoylphosphatidlycholine(DSPC),andionizableamino-lipidssuchasdilinoleylmethyl-4-dimethylaminobutyrate(DLin-MC3-DMA)arepotentsiRNAdeliveryvehiclesinvivo.LNP-siRNAsystemsoptimizetoachievemaximumgenesilencingpotencyinhepatocytesfollowingIVadministrationinmicecontainDLin-MC3-DMA(MC3),DSPC,cholesterolandapolyethyleneglycol(PEG)-lipidatmoleratiosof50/10/38.5/1.5.DLin-MC3-DMAexhibitsanoptimizedpKavaluethatleadstodramaticallyenhancedpotency[1].户使⽤本产品发表的科研⽂献•NatCommun.2021Dec8;12(1):7101.•SciAdv.2021Jan13;7(3):eaba1028.•AnalChem.2022Jun14.•DrugDeliv.2022Dec;29(1):2644-2657.•Pharmaceutics.2022,14(11):2357.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].FerraressoF,StrilchukAW,JuangLJ,PooleLG,LuyendykJP,KastrupCJ.ComparisonofDLin-MC3-DMAandALC-0315forsiRNADeliverytoHepatocytesandHepaticStellateCells.MolPharm.2022;19(7):2175-2182.[2].KulkarniJA,etal.DesignoflipidnanoparticlesforinvitroandinvivodeliveryofplasmidDNA.Nanomedicine.2017May;13(4):1377-1387.McePdfHeight2/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemECaution:Producthasnotbeenfullyvalidatedforme