BOS-172722-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEBOS-172722Cat.No.:HY-112162CASNo.:1578245-44-9分⼦式:C₂₄H₃₀N₈O分⼦量:446.55作⽤靶点:Mps1作⽤通路:CellCycle/DNADamage;Cytoskeleton储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验1MHCl:65mg/mL(145.56mM;ultrasonicandadjustpHto2withHCl)DMSO:5mg/mL(11.20mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.2394mL11.1970mL22.3939mL5mM0.4479mL2.2394mL4.4788mL10mM0.2239mL1.1197mL2.2394mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性BOS-172722单极纺锤体1(MPS1)检查点的抑制剂，其对MPS1(1mMATP)和P-MPS1的IC50值分别为11nM和63nM。BOS-172722可⽤于多种乳腺癌的研究。IC50&Target2nM(MPS1)[1].1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE体外研究BOS-172722isaninhibitorofmonopolarspindle1(MPS1)checkpointwithanIC50of2nM.BOS-172722alsohaspotentialforthetreatmentofvariousformsofbreastcancer[1].体内研究BOS-172722showsexcellentPKinmouse,rat,anddog[1].BOS-172722(50mg/kg)resultsinanincreasedsuppressionofMPS1autophosphorylationat6and24h[1].AnimalModel:Dog[2].Dosage:1mg/kg(iv),5mg/kg(po)(PharmacokineticAnalysis).Administration:IVandPO.Result:T1/2=12h,Cmaxpo=7770nmol/L,AUCpo=147035h*nmol/L.REFERENCES[1].ARYLSULFONOHYDRAZIDES.WO2014037750A1.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792/p>