Zinc-Protoporphyrin-Zn-II-protoporphyrin-IX-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEZincProtoporphyrinCat.No.:HY-101193CASNo.:15442-64-5Synonyms:Zn(II)-protoporphyrinIX;ZnPP;ZincProtoporphyrin-9分⼦式:C₃₄H₃₂N₄O₄Zn分⼦量:626.02作⽤靶点:ReactiveOxygenSpecies;EndogenousMetabolite;Apoptosis作⽤通路:Immunology/Inflammation;MetabolicEnzyme/Protease;NF-κB;Apoptosis储存⽅式:-20°C,sealedstorage,awayfrommoisture*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoisture)溶解性数据体外实验DMSO:20.83mg/mL(33.27mM;ultrasonicandwarmingandheatto80°C)0.2MNaOH:2.5mg/mL(3.99mM;ultrasonicandadjustpHto14withNaOH)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.5974mL7.9870mL15.9739mL5mM0.3195mL1.5974mL3.1948mL10mM0.1597mL0.7987mL1.5974mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoisture)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性ZincProtoporphyrin(Zn(II)-protoporphyrinIX)⼀种具有⼝服活性的，竞争性的⾎红素加氧酶-1(HO-1)抑制剂，显减弱间苯三酚(PG)对H2O2的保护作⽤。ZincProtoporphyrin可⽤作个体孕妇和⼉童缺铁的筛查标志物，也⽤于评估⼈群铁状态与⾎红蛋⽩浓度的组合。ZincProtoporphyrin具有抗癌活性。1/3MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEIC50&TargetHumanEndogenousMetabolite体外研究ZincProtoporphyrin(Zn(II)-protoporphyrinIX;5μM;72hours)causesthefractionoflateapoptoticandnecroticcellsincreasingfrom10.9%incontrolsto30.4%after72h[3].ZincProtoporphyrin(1.25-40μM;48or72hours)exertscystostatic/cytotoxiceffectsagainsttumorcells[3].ZincProtoporphyrin(2.5,5μM;48or72hours)resultsindose-andtime-dependentreductionofcellsinG1phaseofthecellcycle[3].ZincProtoporphyrin(1.25-40μM;48hours)leadstoaccumulationofcleaved(active)caspase-3[3].ApoptosisAnalysis[3]CellLine:C-26cellsConcentration:5μMIncubationTime:72hoursResult:Thefractionoflateapoptoticandnecroticcellsincreasedfrom10.9%incontrolsto30.4%after72h.CellCytotoxicityAssay[3]CellLine:C-26andMDA-MB231cellsConcentration:1.25,2.5,5,10,20,40μMIncubationTime:48or72hoursResult:Exertedcystostatic/cytotoxiceffectsagainsttumorcells.CellCycleAnalysis[3]CellLine:C-26cellsConcentration:2.5,5μMIncubationTime:48or72hoursResult:Resultedindose-andtime-dependentreductionofcellsinG1phaseofthecellcycle.WesternBlotAnalysis[3]CellLine:C-26cellsConcentration:1.25,2.5,5,10,20,40μMIncubationTime:48hoursResult:Leadedtoaccumulationofcleaved(active)caspase-3.2/3MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE体内研究ZincProtoporphyrin(12.5,25,50mg/kgfori.p.;12.5,50mg/kgforp.o.;fromday7to19)exertsdose-dependentantitumoreffectsmanifestedbytheretardationoftumorgrowth[3].AnimalModel:BALB/cmiceinoculatedwithC-26cells[3]Dosage:12.5,25,50mg/kgfori.p.;12.5,50mg/kgforp.o.Administration:IPorPO;fromday7to19Result:Exerteddose-dependentantitumoreffectsmanifestedbytheretardationoftumorgrowth.户使⽤本产品发表的科研⽂献•BoneRes.2022Mar9;10(1):26.•RedoxBiol.2021Dec1;48:102203.•FreeRadicBiolMed.2022Aug23;S0891-5849(22)00558-5.•BiomedPharmacother.2022Aug;152:113255.•OxidMedCellLongev.2022Apr25;2022:3846217.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].ParkC,etal.ProtectiveEffectofPhloroglucinolonOxidativeStress-InducedDNADamageandApoptosisthroughActivationoftheNrf2/HO-1SignalingPathwayinHaCaTHumanKeratinocytes.MarDrugs.2019Apr13;17(4).[2].MwangiMN,etal.DiagnosticutilityofzincprotoporphyrintodetectirondeficiencyinKenyanpregnantwomen.BMCMed.2014Nov26;12:229.[3].NowisD,etal.ZincprotoporphyrinIX,ahemeoxygenase-1inhibitor,demonstratespotentantitumoreffectsbutisunabletopotentiateantitumoreffectsofchemotherapeuticsinmice.BMCCancer.2008Jul11;8:197.McePdfHeight