16-16-Dimethyl-prostaglandin-E2-16-16-dimethyl-PGE2-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemE16,16-DimethylprostaglandinE2Cat.No.:HY-106420CASNo.:39746-25-3Synonyms:16,16-dimethylPGE2分⼦式:C₂₂H₃₆O₅分⼦量:380.52作⽤靶点:ProstaglandinReceptor作⽤通路:GPCR/GProtein储存⽅式:Pureform-20°C3yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:100mg/mL(262.80mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.6280mL13.1399mL26.2798mL5mM0.5256mL2.6280mL5.2560mL10mM0.2628mL1.3140mL2.6280mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.5mg/mL(6.57mM);Clearsolution1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.5mg/mL(6.57mM);Clearsolution3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(6.57mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性16,16-DimethylprostaglandinE2(16,16-dimethylPGE2)⼀种具有⼝服活性的脊椎动物造⾎⼲细胞(HSCs)稳态关键调节剂。16,16-DimethylprostaglandinE2可以通过EP2/EP4起作⽤，并与Wnt途径相互作⽤。体内研究16,16-DimethylprostaglandinE2(16,16-dimethylPGE2;10µg/kg;i.p.;every12hours;for8days)rescuestheexacerbatedDSScolitisphenotypeofTpl2IMF-KOmiceandrestoresepithelialproliferationandstructure[2].AnimalModel:Tpl2IMF-KOmice[2]Dosage:10µg/kgAdministration:IP;every12hours;for8daysResult:RescuedtheexacerbatedDSScolitisphenotypeandrestoresepithelialproliferationandstructure.REFERENCES[1].HagedornEJ,etal.Gettingmoreforyourmarrow:boostinghematopoieticstemcellnumberswithPGE2.xpCellRes.2014Dec10;329(2):220-6.[2].RoulisM,etal.Intestinalmyofibroblast-specificTpl2-Cox-2-PGE2pathwaylinksinnatesensingtoepithelialhomeostasis.ProcNatlAcadSciUSA.2014Oct28;111(43):E4658-67.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonl