2023年医学免疫学人卫版题库

第一章《免疫学概论》练习题一、单项选择题1.免疫是指·······························································（)A、机体辨认和排除抗原性异物的功能Ｂ、机体清除和杀伤自身突变细胞的功能C、机体清除自身衰老、死亡的组织细胞的功能D、机体对病原微生物的防御２．免疫对机体是····························································(）A、有害的B、有利的C、有利也有害D、正常条件下有利,异常条件下有害3．机体抵抗病原微生物感染的功能称为········································(）Ａ、免疫监视Ｂ、免疫自稳 ﻩﻩC、免疫耐受D、免疫防御４．机体免疫系统辨认和清除突变细胞的功能称为································（)Ａ、免疫监视B、免疫自稳 ﻩﻩC、免疫耐受D、免疫防御5．机体免疫系统对自身正常成分耐受，清除衰老、损伤细胞的功能称为··············（)A、免疫监视B、免疫自稳 ﻩﻩＣ、免疫耐受D、免疫防御6.关于固有免疫的特点，下列表述错误的是·····································(）A、可遗传B、感染初期起重要作用C、无免疫记忆D、特异性7．关于固有免疫的特点,下列表述错误的是·····································()Ａ、可遗传B、感染后期及防止再感染中起重要作用C、无免疫记忆D、非特异性8.关于固有免疫的特点,下列表述错误的是·····································（）A、可遗传B、感染初期起重要作用C、有免疫记忆D、非特异性９．关于适应性免疫的特点,下列表述错误的是··································(）A、获得性B、感染初期起重要作用C、有免疫记忆D、特异性１0．关于适应性免疫的特点，下列表述错误的是··································()A、可遗传B、感染后期及防止再感染中起重要作用C、有免疫记忆D、特异性１1.关于适应性免疫的特点,下列表述错误的是··································(）A、获得性B、感染后期及防止再感染中起重要作用C、无免疫记忆D、特异性12．属于固有免疫应答的细胞是···············································()A、T淋巴细胞B、B淋巴细胞 ﻩC、NK细胞D、上皮细胞13.属于适应性免疫应答的细胞是·············································（)A、单核-巨噬细胞Ｂ、中性粒细胞ﻩ C、ＮK细胞D、T、B淋巴细胞二、填空题１.最早接种人痘苗防止天花的国家是。2.免疫系统由、和组成。3.机体的免疫应答可分为两种类型,一种称,另一种称。4.免疫系统三大功能涉及、、。5.在异常情况下，免疫防御功能异常可发生__＿_____＿＿＿＿，免疫防御功能过低或缺如则可发生＿______＿＿＿__病,免疫自稳功能异常易发生______＿___＿_病;免疫监视功能低下可发生＿___＿___＿_＿__。6．固有免疫细胞通过ﻩ 受体辨认病原生物表达的 ﻩ ﻩﻩ。7．固有免疫细胞有、、、等。三、名词解释免疫ﻩ PＡMP ＰＲR四、简答题１．简述免疫系统的三大功能及其生理表现和病理表现。2．试比较固有免疫和适应性免疫的作用特点。第二章《免疫器官和组织》练习题一、单项选择题１.人类的中枢免疫器官是····················································（）Ａ、淋巴结和脾脏B、胸腺和骨髓C、淋巴结和胸腺D、骨髓和黏膜相关淋巴组织2．T细胞和B细胞定居的场合是··············································()A、骨髓B、外周免疫器官和组织C、中枢免疫器官D、胸腺3.下列哪种器官是最大的外周免疫器官········································（)A、肝脏B、扁桃体ﻩﻩﻩC、肠系膜淋巴结Ｄ、脾脏4.既可来源于髓样干细胞，又可来源于淋巴样干细胞的免疫细胞是(）A、单核-巨噬细胞B、中性粒细胞 C、NＫ细胞D、树突状细胞5．淋巴结的胸腺依赖区是····················································()A、皮质区Ｂ、髓质区 ﻩ Ｃ、浅皮质区D、深皮质区6．脾脏的胸腺依赖区是······················································()A、红髓 ﻩB、白髓ﻩﻩ Ｃ、脾小结D、PALS7.淋巴结内T细胞约占淋巴细胞的比例为······································()Ａ、75%B、2５% ﻩﻩ C、50%D、10%８.脾脏内T细胞约占淋巴细胞的比例为········································()A、60%B、40%Ｃ、5０%D、20%二、填空题１．免疫系统由、、组成。2．人类的中枢免疫器官涉及ﻩ ﻩ和ﻩﻩ ，外周免疫器官涉及、、等。3．中枢免疫器官中,B细胞分化、成熟的场合是,Ｔ细胞分化、成熟的场合是。4.人造血干细胞的重要表面标志为和。5.在骨髓人分化成熟的淋巴细胞有和。三、名词解释淋巴细胞归巢ﻩ 淋巴细胞再循环四、简答题１．简述免疫系统的组成。2．简述中枢免疫器官的组成和各器官重要功能。 3.简述外周免疫器官的组成和各器官重要功能。４．何谓淋巴细胞再循环,其生物学意义是什么？第三章《抗原》练习题一、单项选择题1．下列没有免疫原性的物质是················································（)A、异嗜性抗原Ｂ、抗体 ﻩC、补体Ｄ、半抗原２．抗原的特异性取决于······················································()Ａ、抗原决定基的性质B、抗原决定基的数量Ｃ、抗原分子量的大小D、载体的性质3．TＤ-Aｇ得名,是由于它·····················································(）A、在胸腺中产生B、相应抗体在胸腺中产生C、对此抗原不产生体液免疫Ｄ、相应的抗体产生需要T细胞辅助4．下列不属于ＴＤ-Aｇ的是···················································()Ａ、血清蛋白B、细菌外毒素 C、类毒素D、细菌脂多糖5．仅有抗原性而无免疫原性的物质称为········································（）Ａ、超抗原B、半抗原 ﻩﻩC、完全抗原Ｄ、异嗜性抗原6．存在于人、动物及微生物等不同种属之间的共同抗原称为·······················（）A、异种抗原B、交叉抗原ﻩﻩﻩＣ、超抗原D、异嗜性抗原7.同一种属不同个体之间存在的不同抗原称为··································(）A、异种抗原Ｂ、同种异型抗原 Ｃ、独特型抗原D、Ｆｏrｓsｍan抗原８.引起同胞兄弟之间移植排斥反映的抗原属于··································()A、异种抗原B、同种异型抗原 ﻩC、自身抗原Ｄ、Forssｍａn抗原９.动物来源的破伤风抗毒素对破伤风病人而言是································（）A、半抗原B、抗体 ﻩﻩC、抗原D、既是抗体又是抗原10．从化学属性而言，下列免疫原性最强的物质是································()A、蛋白质Ｂ、多糖类ﻩﻩﻩC、类脂D、核酸11．关于佐剂,下列表述是错误的是············································（）A、佐剂是特异性免疫增强剂B、可延长抗原在体内潴留时间C、动物实验中最常用佐剂的是弗氏完全佐剂和弗氏不完全佐剂Ｄ、可刺激APC,增强其对抗原的加工和提呈1２.下列属于同种异型抗原的是···············································（)A、食入的异种蛋白Ｂ、改变的自身成分 C、异嗜性抗原D、血型抗原13.下列属于超抗原的是·····················································（)A、IgGB、白蛋白ﻩﻩﻩC、丝裂原D、热休克蛋白14．TD-Ａg具有的表位通常是·················································(）A、T细胞表位B、既不是T细胞表位，也不是Ｂ细胞表位C、B细胞表位ﻩﻩ D、同时有T细胞表位和B细胞表位15．有的抗原被称为ＴI抗原,这是由于·········································()Ａ、来源于非胸腺组织ﻩﻩﻩﻩﻩB、诱生的抗体重要在骨髓中产生C、往往具有多个不同的抗原决定基 ﻩD、刺激B细胞产生抗体,不需要Ｔ细胞辅助1６．属于异嗜性抗原的是·····················································()Ａ、Ｒh抗原与人的红细胞 ﻩ B、马血清与破伤风梭菌C、AFP与乙型肝炎病毒 ﻩﻩﻩD、大肠埃希菌O14与人结肠黏膜１7．关于超抗原,下列描述错误的是············································（）A、直接与APC的MＨＣ类分子非多态性外侧结合ﻩﻩB、不要ＡPC加工解决C、与TＣRV链结合 ﻩ ﻩ D、有MＨC限制性18．关于TI抗原，下列描述错误的是···········································()A、只有B细胞表位，无T细胞表位ﻩﻩ B、激活的细胞为B１细胞C、无ＭHC限制性ﻩﻩ ﻩﻩﻩﻩD、产生的抗体重要是IgG19．只具有与抗体结合能力，而单独不能诱导机体产生相应抗体的物质是···········（)A、完合抗原ﻩ ﻩB、TD抗原ﻩﻩ C、ＴI抗原ﻩ D、半抗原2０.与载体蛋白偶联后才获得免疫原性的物质是·································（)A、超抗原 ﻩB、半抗原 C、TI抗原ﻩﻩﻩD、TＤ抗原21．甲、乙两种抗原都能与某一抗体发生特异性结合反映,这两种抗原互相称为·······（)A、半抗原 B、共同抗原ﻩﻩﻩC、完全抗原 D、同种异型抗原二、填空题1．具有而无的物质称为半抗原。2.具有性和性的物质为完全抗原。3．抗原的异物性可存在于之间、之间以及。4.影响抗原免疫原性的因素有_________、__＿___＿_＿和三个方面。5．影响免疫原性的抗原理化与结构性质涉及______ﻩ、 ﻩ、 、ﻩ ﻩ、ﻩ ﻩﻩ、 ﻩ 和等。6.抗原决定基在结构上分为两类,即决定基和决定基。7.抗原根据诱生抗体时是否需要T细胞参与分为抗原和抗原。8．抗原决定基根据被辨认的淋巴细胞受体不同分为决定基和决定基。9.B细胞辨认的表位通常是天然的，位于抗原分子表面的或表位；Ｔ细胞辨认的表位是由APＣ加工提呈的，即表位。10．自身抗原的形成因素涉及、和等。11.常见的人类同种异型抗原有、和等。12．作用于人T淋巴细胞的丝裂原有、和。1３．作用于人B细胞的丝裂原有和。三、名词解释抗原 完全抗原 半抗原/不完全抗原ﻩ 表位/抗原决定基载体效应 ﻩ交叉反映 TD-Agﻩ ﻩﻩTI-Ag异嗜性抗原ﻩﻩ超抗原ﻩ 佐剂四、简答题1.抗原的两个基本特性及其含义是什么?２.简述影响抗原免疫原性的因素。3.动物免疫血清对于人的两重性表现在哪里？4.何谓佐剂？佐剂的作用机制有哪些？5.简述超抗原激活T细胞的机制。五、问答题1.T细胞表位与Ｂ细胞表位有何不同？2．试比较TＤ-Ａg与TI-Ag的特性。3．试述超抗原与普通抗原的比较。第四章《抗体》练习题一、单项选择题１．抗体与抗原结合的结构域是················································(）A、VHＢ、VLﻩ ﻩﻩC、CH Ｄ、ＶH和VL2．ＩｇＧ与Ｃ1ｑ结合的结构域是················································(）Ａ、CH１B、CH2 ﻩ C、ＣH3D、VＨ和VL３.IgＭ与Ｃ1q结合的结构域是················································()A、CH1B、ＣＨ２ﻩﻩﻩＣ、CH3D、VH和VL4.ＩgG与吞噬细胞或ＮK细胞表面ＦcR结合的结构域是··························（）A、CH１B、ＣH2 ﻩC、CH３D、VH和ＶL5．血清中含量最高的Ｉｇ是···················································（)Ａ、IgＡＢ、IｇM ﻩ C、ＩgGD、ＩgＤ6.与抗原结合后激活补体能力最强的Ig是·····································（）A、IｇAＢ、IｇＭﻩ C、IgGD、IｇD7.能通过胎盘的Ｉg是·······················································（）Ａ、IgAＢ、ＩgG ﻩC、ＩgMD、ＩgＥ8．脐血中含量增高提醒胎儿有宫内感染的Ig是·································（）A、IgAＢ、IgＭ C、IgGD、IgD9．在初次感染病原微生物后,机体最早产生的抗体是·····························（）A、ＩgAB、IgＭ Ｃ、IgGD、IgD１0.分子量最大的Ｉg是······················································（）A、IｇAB、IgM C、IｇGD、IｇＤ11．新生儿从母乳中获得的抗体是·············································（)A、ＩｇA B、IｇM ﻩ C、IgG ﻩD、ＳIgA１2.产生抗体的细胞是·······················································（)A、T细胞Ｂ、Ｂ细胞 ﻩC、浆细胞D、ＮＫ细胞１3．sIgA的组成为··························································（）A、二个IgA单体与一个J链ﻩﻩB、二个IgＡ单体与一个J链和一个分泌片C、一个IgA单体与一个J链ﻩ Ｄ、一个IgＡ单体与一个J链和一个分泌片１4．能与肥大细胞表面FcR结合,介导Ⅰ型超敏反映的Ig是·······················（）A、ＩgＡB、IgＭﻩ ﻩC、IgGD、IｇE15.天然ABO血型抗体属于··················································（)A、IgAB、IｇMﻩ ﻩC、ＩgGD、ＩgD16．具有J链结构的Ig是·····················································（)A、ｓIｇA、IgＧＢ、IgM、sIgA ﻩＣ、ＩgＧ、IgDD、IgD、IgE17．J链合成缺陷后受影响的Iｇ是·············································()Ａ、IｇＧ和IｇＥB、ＩgMﻩ ﻩC、IｇAD、ＩgM和sIgA1８．参与黏膜局部抗感染的Ig是··············································(）A、ＩgA ﻩ B、IgMﻩ ﻩ Ｃ、sIgＡﻩﻩﻩＤ、IgG19．抗体分子基本结构的组成是···············································()A、２条重链和2条轻链ﻩﻩﻩ B、1条重链和1条轻链C、2条相同的重链和2条相同的轻链 D、4条相同的肽链2０.下列不属于抗体的功能为·················································（）A、与抗原结合ﻩB、激活补体 ﻩC、杀灭细胞D、调理作用2１．合成sIｇA分泌片的细胞是················································（）A、巨噬细胞 Ｂ、血管内皮细胞ﻩﻩＣ、浆细胞Ｄ、黏膜上皮细胞２２．IgG易被蛋白水解酶作用的部位是·········································(）A、铰链区ﻩB、VH和VL ﻩ C、ＣH1D、CＨ２23.成熟Ｂ细胞的BＣR的Ig类型是············································()A、mIｇA和mIgMﻩB、ｍＩｇM和mIｇD C、mIgＧ和mIgEﻩD、mIｇE和mＩgD24．具有CH4结构域的Ig为··················································()A、sＩｇA和IgＭ B、IgM和IｇD Ｃ、IgM和ＩgE Ｄ、IgE和ＩｇG25．关于抗体，下列描述错误的是··············································（)Ａ、抗体都是球蛋白ﻩﻩ ﻩ Ｂ、抗体重要存在于体液中C、抗体能与相应抗原特异性结合ﻩ D、抗体由浆细胞产生26．介导NK细胞等效应细胞产生ADCC效应的Ｉg重要是·························()A、IgＡB、IgＤ ﻩ C、IｇGＤ、IｇM2７.关于Ig的铰链区，下列表述错误的是·······································(）A、位于CＨ1和ＣH2之间ﻩﻩ ﻩB、富含脯氨酸C、易于伸展弯曲 ﻩﻩﻩ Ｄ、五类Ig铰链区相同28．ｓIgA分子中分泌片的重要功能是··········································(）A、连接2个ＩgA单体 ﻩﻩﻩ B、维持ｓIｇA的立体构象C、保护sIgA免遭蛋白酶的水解ﻩ ﻩ ﻩD、促进抗体与抗原的结合2９.抗体发挥中和毒素作用重要依赖其·········································()Ａ、C区的作用ﻩﻩB、调理作用 ﻩ Ｃ、ADCC作用 D、V区的作用３0.IgＭ的实际抗原结合价为·················································（)A、1价ﻩ ﻩB、2价ﻩ Ｃ、5价ﻩﻩ Ｄ、10价二、填空题1.抗体分子的基本结构是由两条相同的和两条相同的通过链间________＿＿连接而成的四肽链结构。2.IgA、IgＭ、ＩｇＧ、IgＥ、ＩgD相应的重链分别为、、、、。３.五类Ig中，血清含量最高的是，具有Ｊ链和分泌片的是，分子量最大的是,能介导Ⅰ型超敏反映的是，能通过胎盘的是。４.免疫球蛋白轻链可分为型和型。5．用木瓜蛋白酶水解IgＧ可得到两个相同的片段和一个片段;用胃蛋白酶水解IgG可获得一个能与抗原结合的片段和无生物学活性的片段。６．IgG铰链区位于与之间的区域,其补体（C1q）结合点位于。７．具有Ｊ链结构的免疫球蛋白有和。８.sIgA由二个IgA单体与和组成，重要存在于外分泌液中,在局部黏膜免疫中发挥重要作用。三、名词解释抗体 ﻩﻩIｇﻩ ﻩCDR独特型(Id) 抗体的调理作用ADCC作用ﻩﻩ单克隆抗体 基因工程抗体四、简答题1.简述免疫球蛋白的基本结构。２.简述IgG分子的结构域组成及各结构域分别有何功能。3．试述IｇG的重要免疫学特性及功能。4.试述IgＭ的重要免疫学特性及功能。5.试述sIgA的分子结构组成、分布及重要免疫学功能。五、问答题１．试述抗体的功能。第五章《补体系统》练习题一、单项选择题1．补体激活的经典途径中，其补体成分的激活顺序是·····························()A、Ｃ１→C2→C3→Ｃ4→Ｃ5→C６→C7→C8→C9B、C1→C２→Ｃ4→C３→C５→C６→C7→C8→C９C、C1→C4→C5→C2→C3→C6→C７→C8→C9D、Ｃ1→C4→Ｃ2→C3→C5→C6→C7→C8→C92.下列补体固有成分中含量最高的是··········································（)A、C3B、C4ﻩ ﻩＣ、C1ｑD、C23．具有调理作用的补体裂解片段是············································（）A、C2b ﻩB、C3b ﻩ Ｃ、Ｃ3aﻩﻩ D、C5ｂ４．具有过敏毒素作用的补体组分是············································（）A、Ｃ3a、C４a、C5ａ B、C3a、C4a C、C2ａ ﻩD、C３ｂ、C4ｂ5.构成膜袭击复合物的补体成分是············································（)A、C6b～9B、C4b2aﻩﻩ C、C5b6789nD、Ｃ３bBb6.与抗原结合后,可通过经典途径激活补体系统的Ｉg是··························（）Ａ、IgA、IgGB、IgM、IgG ﻩ Ｃ、sIgＡ、IｇDD、IgA、IｇM7.可以激活补体旁路途径的成分是············································()A、内毒素Ｂ、抗原抗体复合物ﻩ C、IgMD、MBＬ8.关于补体对的的叙述是····················································（)A、补体成分在血液中处在活化状态 B、旁路途径的活化是从C２开始的C、补体的理化性质稳定 ﻩ D、补体重要是由肝细胞和巨噬细胞产生的9.三条补体激活途径的共同点是··············································（)A、参与的补体成分ﻩ B、C3转化酶的组成C、激活物质 D、膜袭击复合物的形成及其溶解细胞效应1０.与免疫球蛋白Fc段的补体结合部位相结合的补体分子是······················(）Ａ、Ｃ3B、Ｃ1qﻩﻩﻩC、C１rD、C1ｓ11.既对中性粒细胞具有趋化作用又可激发肥大细胞释放组胺的补体裂解产物是·····(）Ａ、C3bB、C4b ﻩﻩC、C４aD、C5a12.某些补体片段能促进吞噬细胞的吞噬作用,是由于吞噬细胞表面存在············（）A、D因子受体B、C3b受体 ﻩＣ、C5a受体Ｄ、C3a受体1３.下列补体活化中形成的转化酶中，不包含补体C3b成分的是····················(）A、经典途径Ｃ５转化酶 B、旁路途径Ｃ５转化酶C、经典途径Ｃ3转化酶 ﻩﻩ D、旁路途径C3转化酶14.下列具有溶细胞作用的补体成分是·········································（）A、C1Ｂ、B因子 C、C3ｂD、C5b６789n15．下列具有趋化中性粒细胞的补体成分是·····································（)Ａ、C1B、C４bﻩﻩﻩＣ、C３bＤ、C5ａ１6．补体激活经典途径的C３转化酶是··········································（)A、C4a2aB、C4a２bﻩﻩ C、C4b2bD、C4ｂ2a17．补体激活经典途径的C５转化酶是··········································（)A、C3bBbＢ、C4b2a ﻩC、C3bnBbD、Ｃ4b2a3b18．补体激活旁路途径的Ｃ5转化酶是··········································（)A、Ｃ3bBbB、C4b2ａﻩﻩC、C3ｂnBｂＤ、C4b2a3b19.补体激活旁路途径的C３转化酶是··········································(）A、C3ｂBbB、C4ｂ2a C、C3bｎＢbＤ、C４b2a3b2０.补体激活凝集素途径的Ｃ5转化酶是········································(）A、C３ｂBｂB、C4b２aﻩﻩC、C３bnＢｂD、C4b２a3b二、填空题1．补体系统由、及组成。2.C１由、、三种蛋白组成。3．补体旁路途径的激活物质是；类和类抗体与抗原结合形成的免疫复合物可经经典途径激活补体。４．具有趋化因子作用的补体片段是；具有调理作用的补体片段有、和。5．具有炎症介质作用的补体片段有、和;补体攻膜复合物（MAＣ）的组成是。三、名词解释补体 补体的调理作用ﻩﻩ免疫黏附作用 ＭAC四、简答题1.简述补体膜袭击复合物（MAC）的组成及其靶细胞溶解的效应机制。2.简述补体的生物学功能及相应的补体成分。五、问答题1.比较补体经典途径和旁路途径的异同点（激活物、参与的补体成分、C3转化酶、C5转化酶及作用等）。第六章《细胞因子》练习题一、单项选择题1.关于细胞因子，下列叙述错误是········································(）A、一般是小分子蛋白质 B、与CKR结合后才干发挥作用Ｃ、重要以内分泌方式发挥作用ﻩ D、生物学效应具有拮抗性和重叠性2．具有趋化功能的细胞因子称为········································（）Ａ、ｉnterleukinＢ、inteｒfｅｒｏn C、gｒoｗthｆａｃtｏrD、ｃhｅmｏkiｎe3.能直接杀伤肿瘤细胞的细胞因子是(）A、ＩFN-B、TGF－ ﻩﻩC、ＴＮFD、CSF4．关于细胞因子的作用特点，下列叙述错误是···································（）A、作用品有多效性 ﻩ ﻩﻩﻩB、合成和分泌是一种自我调控的过程Ｃ、重要参与免疫反映和炎症反映 ﻩ D、以特异性方式发挥作用二、填空题1.细胞因子通过、和方式发挥作用。2．细胞因子重要涉及、、、、和六大类。3．Ⅰ型干扰素涉及和，Ⅱ型干扰素是指。Ⅰ型干扰素重要由 细胞产生，Ⅱ型干扰素是重要由活化的和细胞产生。4.细胞因子中，ＩL是指,TＮF是指,IFN是指，ＣSＦ是指。5．趋化因子根据靠近氨基端的半胱氨酸残基的个数以及排列分为、、和四个亚家族。6.细胞因子的重要生物学活性涉及和两个方面。7.TNＦ-重要由ﻩ细胞产生，TＮF-重要由细胞产生。三、名词解释细胞因子 ﻩＣSF ﻩTNF四、简答题1．简述细胞因子作用方式和功能特点。２．细胞因子分哪几类?请分别写出其中文名和常用英文缩写。第七章《白细胞分化抗原和黏附分子》练习题一、单项选择题１.ＬFＡ－１的配体是··························································（)A、LＦA-2B、E-选择素ﻩ C、ICAM-1D、LＦＡ-32．选择素重要辨认的配体是··················································（)A、CD1５sB、CD8ﻩﻩＣ、ICAM-1D、Ｃ343．CD2又称为······························································()A、ICAＭ-1Ｂ、LＦA-１ﻩ C、LFＡ－2Ｄ、ＬFA-３4.淋巴细胞归巢受体的配体是················································（)A、血管地址素Ｂ、P-选择素ﻩ C、L-选择素D、VLA5．炎症过程中中性粒细胞表面的唾液酸化路易寡糖与内皮细胞互相作用的分子是····(）Ａ、血管地址素B、ICAM-1 C、L－选择素D、Ｅ-选择素6.淋巴细胞归巢中,淋巴细胞表面的Ｌ选择素与血管内皮细胞互相作用的配体分子是·(）A、GlｙCAM-1B、ICＡＭ-1ﻩﻩＣ、ｓLｅXD、E-选择素二、填空题１．根据黏附分子结构特点的不同，可将其分为家族、家族、家族等。2．选择素家族涉及、和三个成员。3．选择素分子的胞膜外区均具有结构域、结构域的结构域。4．黏附分子的重要功能有、及等。５.介导淋巴细胞归巢的黏附分子中,表达在淋巴细胞表面的称为,表达在血管内皮细胞表面的称为。三、名词解释白细胞分化抗原CD细胞黏附分子第八章《重要组织相容性复合体》练习题一、单项选择题1.关于MHCⅠ类分子,下列叙述对的的是······································（)A、MＨCⅠ类分子的肽链均为MHＣ编码Ｂ、HLＡⅠ的链分子由HLA复合体的基因编码Ｃ、为2条相同的重链和2条相同的轻链组成的四肽链结构D、重要参与外源性抗原的提呈2.关于MHＣⅡ类分子,下列叙述错误的是······································()A、MＨCⅡ类分子的2条多肽链均为ＭＨC的基因编码B、经典的ＭＨCⅡ类分子涉及HＬA－DP、HLA-ＤＱ、HLA-ＤRC、重要存在于AＰC的表面Ｄ、广泛分布于各种有核细胞表面３．与强直性脊柱炎密切相关的HLＡ分子是·····································（)A、HLA－Ａ5Ｂ、HLＡ-B８ﻩ ﻩＣ、ＨLA-B7Ｄ、HＬA-B274．HＬA单体型是指·························································(）A、一条染色体上HＬA复合体等位基因的组合 ﻩB、个体HＬA表型的组合Ｃ、两条染色体上HLＡ复合体等位基因的组合ﻩﻩ D、个体HLＡ表型的一半5．ＨLＡⅠ类分子的肽结合结构域位于·········································(）A、α1,β1B、β2m ﻩ C、α1,α2D、β1,β２6．ＨLAⅡ类分子的肽结合结构域位于·········································（）A、α1,β1B、β2mﻩ ﻩC、α1,α2Ｄ、β1,β27．亲代与子代有一个HＬA单体型相同的机制是·································(）A、单体型遗传ﻩB、多态性 Ｃ、连锁不平衡D、性连锁遗传８．同胞之间ＨLA复合体基因完全相同的概率为·································（)ﻩA、１0% ﻩﻩB、２5% ﻩ C、50％ﻩ D、１00％9.同胞之间HＬA复合体基因完全不同的概率为·································(）ﻩＡ、1０%ﻩﻩﻩB、25%ﻩ ﻩC、５0%ﻩﻩ D、1０0%10.同胞之间一个ＨLA复合体相同的概率为····································() A、10％ﻩﻩ B、2５％ﻩ ﻩC、50%ﻩ D、10０%11．活化的人Ｔ淋巴细胞表达的MHC分子有····································（）ﻩA、MHCⅠ类分子ﻩ ﻩ B、ＭHCⅡ类分子ﻩC、ＭＨCⅠ类、Ⅱ类分子ﻩﻩﻩﻩＤ、ＭHCⅠ类、Ⅲ类分子12.ＨLAⅡ类分子重要表达于················································（）A、T细胞表面B、APC表面 ﻩC、红细胞表面Ｄ、肝细胞表面１3.下列属于移植抗原的是···················································（）A、CD分子B、CKs ﻩﻩC、AＭD、HLA分子14．ＭHC分子的重要功能是··················································(）A、决定组织相容性ﻩﻩﻩﻩ Ｂ、引起移植排斥应C、决定机体对某些疾病的相关性ﻩﻩD、提呈抗原1５．关于ＭHC中的PSMB,下列描述错误的是···································(）A、为蛋白酶体亚单位基因B、其基因产物参与内源性抗原的解决Ｃ、涉及PSＭB8和PSＭＢ9两个座位D、其基因产物能将内源性抗原肽转运入内质网16.关于TAP分子，下列表述错误的是·········································（)A、即抗原加工相关转运物B、分别由TＡP1和TAP2两个座位基因编码Ｃ、其功能是将内源性抗原肽从胞质转运入内质网D、其功能是降解外源性抗原1７．对HＬＡ－DＭ基因表述错误的是············································()A、属免疫功能相关基因 ﻩﻩＣ、编码产物参与外源性抗原的加工提呈B、涉及DMA和DMB座位 D、编码产物参能降解外源性抗原18.关于MHCⅡ类分子，下列表述错误的是·····································(）A、表达在B细胞和Ｔ细胞表面 ﻩＢ、与巨噬细胞的抗原提呈作用相关Ｃ、在人群中表现为高度多态性 ﻩD、有CD４分子的结合部位19.MHCⅡ类分子与CD4分子结合的结构域是··································（）A、α1、α2Ｂ、α3ﻩ Ｃ、α１、β１Ｄ、β２20．MHCⅠ类分子与CD8分子结合的结构域是··································()A、α1、α2B、α３ﻩﻩ Ｃ、β2mD、α1、β121．与类风湿关节炎重要关联的HLA分子是····································（）A、HＬA-Ｂ27B、ＨＬA-DＲ２ﻩ Ｃ、HLA-ＤR４D、ＨLA-DR52２．关于MHCⅠ类分子的肽结合结构域,下列表述错误的是·······················()A、肽结合结构域由α1、α2结构域组成B、由2个α螺旋和8个β折叠股构成肽结合槽C、肽结合槽的两端开放D、结合的抗原肽的长度为8～10个氨酸残基2３．关于ＭHCⅡ类分子的肽结合结构域,下列表述错误的是·······················（)A、肽结合结构域由α１、β1结构域组成B、α1和β1结构域各行成由1个α螺旋和４个β折叠股C、结合的抗原肽的长度为１3～17个氨酸残基D、肽结合槽与相应氨基酸序列的抗原肽结合二、填空题1．人类MHＣ称为，其编码产物称为。2．ＨＬＡ复合体的遗传特性有、、等。3.HLＡ复合体位于人第染色体短臂,类基因集中于远离着丝点一端，类基因集中于近着丝点一端。4.ＨLA复合体定位于ﻩﻩﻩ ﻩ,全长 ﻩ ，共有ﻩﻩﻩﻩ个基因座位，其中功能性基因 ﻩ 个。5.Tｈ与APC作用、Th与Ｂ细胞作用受ＭHC类分子限制；CＴＬ与靶细胞作用受MHC类分子限制。6.ＨLA复合体中编码经典Ⅰ类分子链的基因座位有、、；编码经典Ⅱ类分子的基因亚区有、、。７.PSMＢ的中文名称为ﻩﻩ ﻩﻩ ,该基因编码产物为ﻩﻩﻩ的组成成分之一,后者的功能是ﻩﻩﻩ ﻩ 。8.TAＰ分子的中文名称为ﻩﻩ ,其基因座位有ﻩ 和ﻩﻩ，TAP的功能是ﻩ ﻩﻩ 。9．HLＡ非经典Ⅰ类分子有 ﻩ和ﻩﻩﻩ ﻩ。1０.MⅠC基因家族涉及ﻩ 和 ﻩ两个基因，其编码的产物为ﻩﻩ 的配体。三、名词解释MHＣﻩﻩＨLA复合体 MHC限制性ﻩ 锚定残基 共用基序TAP(ｔranspｏｒtersassｏciatedwｉtｈanｔiｇenｐrocｅssｉng）PＳMB(ｐｒoteaｓomesuｂｕnitβtｙpｅ)四、简答题1.简述HLA复合体的遗传特点。2.简述PＳMB、TAP和HLA-ＤＭ分子在抗原加工提呈中的作用。3．简述ＨLA与临床医学的关系。五、问答题１.试述经典的HLAⅠ类分子和Ⅱ类分子的编码基因座位／亚区、分子结构(结构域组成和作用)、表达特点、组织分布和功能特点。2．试述HLＡ分子选择性结合含共用基序的抗原肽具有相对专一性的意义。３.试述HLA分子的功能。第九章《B淋巴细胞》练习题一、单选题1.与mIg共同组成BCR复合物的是···········································(）A、CD19和CD21 B、ＣＤ79a和CD79bＣ、CD8０和CD８６ﻩ D、CD2８和CD1522.鉴别Ｂ-1细胞和B－2细胞的重要表面标志是···································(）A、CＤ4B、CＤ8Ｃ、ＣD40Ｄ、CD５3．B细胞上的ＥB病毒受体是·················································(）Ａ、CD5B、CD19C、CD2１D、ＣD22５4.B－1细胞辨认的抗原重要是················································()Ａ、颗粒性抗原Ｂ、蛋白质抗原C、脂类抗原Ｄ、碳水化合物类抗原5．可刺激成熟Ｂ细胞增殖和分化的细胞因子是··································（)A、IＬ-4B、IＦN-γC、IL-12D、TGＦ-β６.不成熟B细胞表达的mIg重要是············································(）A、mIｇAB、mＩgMＣ、mＩｇＤD、mIgE７.具有多反映性的细胞是····················································()A、B-1细胞B、B-２细胞C、Th1细胞Ｄ、Th2细胞８.与B细胞活化第二信号有关的膜表面分子是··································（）A、CD40ＬＢ、CＤ28C、CD８0D、ＣＤ8６9．人类B细胞分化成熟的场合是··············································(）Ａ、胸腺ﻩﻩB、脾脏 Ｃ、骨髓 ﻩD、淋巴结10.关于B1细胞,下列叙述错误的是···········································()Ａ、产生的抗体亲和力较低B、产生的抗体可与多种不同的抗原表位结合C、产生的抗体多为IｇMＤ、重要对蛋白质抗产生免疫应答11．B细胞表面的ＣD40与T细胞表面的ＣD40L结合可介导························（)A、B细胞活化 ﻩ B、B细胞分化成熟C、Ｔ细胞活化ﻩﻩﻩ D、T细胞分化成熟１2．B-1细胞对碳水化合物抗原发生应答后，产生的抗体重要是···················（)A、高亲和力IgG型抗体 ﻩ B、低亲和力IgＧ型抗体Ｃ、高亲和力IgM型抗体 ﻩ D、低亲和力ＩgM型抗体13．成熟B细胞表达的mＩg重要是·············································（）A、mIｇA和mIｇGﻩﻩﻩB、mIgM和ｍIgAC、mIgD和mIgMﻩ D、mＩgE和ｍIgＧ１4．Ｂ细胞共受体不涉及·····················································()A、CD1９ﻩﻩ B、CD20 C、ＣD21ﻩ D、ＣD８１１５．关于Ig/Iｇ,以下表述错误的是···········································()Ａ、与mＩｇ组成ＢCＲ复合物 ﻩＢ、可转导B细胞活化的第一信号C、胞浆内具有ＩＴＡM ﻩ Ｄ、自前B细胞开始表达1６.关于前Ｂ细胞受体（pｒe-BCＲ),以下表述错误的是·····························（）A、由链和替代轻链组成 ﻩB、替代轻链由Vｐre－B和５两种蛋白组成C、 具有辨认相应抗原的作用ﻩﻩD、表达于前Ｂ细胞17.关于替代轻链,以下表述错误的是··········································()Ａ、与链共同组成前B细胞受体ﻩB、Vprｅ-B和5分别与Ig轻链Ｖ区和C区同源C、由Vprｅ-Ｂ和5两种蛋白组成ﻩD、表达于祖B细胞１8．在BCR的胚系基因结构中，编码ＩｇH链V区的基因片段是······················（）A、Ｖ基因片段ﻩﻩﻩﻩﻩB、V基因片段和Ｊ基因片段C、V基因片段和D基因片段 ﻩＤ、V基因片段、D基因片段和J基因片段19．关于在BCＲ的胚系基因结构中链基因,以下表述错误的是····················（）A、基因位于2号染色体的短臂B、由编码V区的V基因片段、J基因片段及编码C区的C基因片段组成C、其J基因片段与Ｃ基因片段配对排列,形成J-C结构D、编码V区的V基因片段和J基因片段均有多个基因片段组成20.关于BCＲ重链的基因重组，以下表述对的的是·······························(）A、发生于前B细胞ﻩﻩ B、先V－Ｊ重组,再VJ-D重组C、先D-J重组,再V－DJ重组 ﻩD、重链的基因重组发生于轻链成功重组之后２1.关于BＣR重链的基因重组,以下表述错误的是·······························（）Ａ、参与基因重组的酶有RＡG、TdT等Ｂ、RAG可辨认并切除Ｖ（Ｄ）J基因片段两侧的RSSC、TdＴ可在基因重组过程中出现的DNA断端切除若干个核苷酸Ｄ、B细胞中一条染色体上的重链基因重排成功后，克制另一条同源染色体上重链的基因重排２2．关于BCR轻链的基因重组，以下表述错误的是·······························(）A、发生在前B细胞阶段 ﻩB、链基因重排不成功，再重排链基因C、发生于重链重排成功之后ﻩ D、ＢCＲ轻链重排成功后，该细胞表达ＢCR二、填空题1．Iｇα／Igβ的重要功能为转导及参与。２.B细胞共受体由、和分子组成，其作用是。３.给B细胞活化提供共刺激信号重要的一对共刺激分子是B细胞表面的与Ｔ细胞表面的。4．不成熟B细胞表达的mＩg为;成熟Ｂ细胞表达的mIg重要为和。5.B细胞的功能有、和。6.B细胞在骨髓中的发育分为 、 ﻩ、和四个阶段。７．ＢCＲ的胚系基因结构中,人ＩgH链基因群位于,其编码Iｇ重链可变区的基因片段有、和 ；链基因群位于,链基因群位于,编码轻链V区的基因片段有和。8.不同发育阶段的B细胞表达不同的分子，其中祖B细胞表达 ﻩ ,前B细胞表达ﻩ ，未成熟B细胞表达ﻩ ﻩ ，成熟B细胞表达ﻩ ﻩ。9．Ｉｇ重链基因重排发生于B细胞发育的 ﻩ 阶段,轻链重排发生于B细胞发育的ﻩ ﻩ阶段。１0．ＢCＲ多样性产生的机制有ﻩﻩﻩﻩ、ﻩ 、ﻩ ﻩ和 ﻩ。11．B细胞表达的共刺激分子重要有ﻩ 和 ﻩﻩ；前者的配体是 ﻩ ，后者的配体有ﻩﻩ 和ﻩﻩﻩ。12．给Ｔ细胞活化提供共刺激信号重要的一对共刺激分子是ﻩ 和ﻩ ﻩ。13.给B细胞活化提供共刺激信号重要的一对共刺激分子是ﻩﻩﻩ和 ﻩﻩ。14．B细胞根据是否表达 分子分为B1细胞和B２细胞。1５.参与BＣR基因重排的重组酶涉及 ﻩﻩ、 ﻩ 、ﻩ 和ﻩ 等。16.重组激活酶可特异性辨认并切除V（D）Ｊ基因片段两侧的ﻩ ﻩ;TdT的中文全称为ﻩ ﻩﻩ，其作用是ﻩ ﻩﻩﻩﻩﻩ ﻩ。二、名词解释BＣＲ复合物ﻩﻩﻩ前Ｂ细胞受体ﻩ 替代轻链 Ｂ细胞共受体基因重排ﻩ 受体编辑ﻩﻩ 等位排斥 ﻩ同型排斥ＩＴＡM ﻩﻩ 体细胞高频突变四、简答题1.简述Ｂ-1细胞表面标志、抗原辨认和免疫应答等特点。２.简述B细胞中枢耐受形成的机制。五、问答题1．试述ＢCR多样性产生的机制。2．试述B细胞重要表面分子及其作用。第十章《T淋巴细胞》练习题一、单选题1．下列不属于Ｔh１型细胞因子是··············································（）A、IL-2B、IL－4C、TNFD、ＩFＮ-γ2．临床上用于鉴别T细胞的表面标志是········································（)Ａ、CD2B、CD3Ｃ、CD4Ｄ、TＣＲ3．胞质区具有ＩＴAM基序的ＣＤ分子是·········································()A、CD３Ｂ、CD4C、CＤ28D、CＤ1５2（CTＬA-4)4.HIV包膜蛋白gｐ1２０受体是················································(）A、CD２B、CD3C、CＤ4D、CD85.与ＭHCⅡ类分子结合的ＣＤ分子是··········································（）A、CD３Ｂ、CD4C、CD8D、CＤ286.与MHCⅠ类分子结合的CＤ分子是··········································()A、CD3B、CＤ4C、CD8D、CD287.MHCⅡ类分子与CD4分子结合的结构域是···································（）A、α1结构域 B、β１结构域C、α2结构域 D、β2结构域8．MHCⅠ类分子与CD8分子结合的结构域是···································（）A、α1结构域ﻩﻩB、α2结构域C、α３结构域ﻩD、β２结构域9.胞质区具有ITIM，能与CD80/CD８6结合的ＣD分子是··························(）Ａ、CD3Ｂ、CD２8C、CD1５2D、CD210.下列不属Tｈ2型细胞因子是···············································（)A、IFN-γB、IL-4C、IＬ-10D、IL-５11.通过度泌IL10和TGF-β对免疫应答发挥负调节的T细胞是·····················（）Ａ、Th1Ｂ、Th2ﻩＣ、Ｔh3D、Tr112．重要辨认外源性抗原肽-MＨＣⅡ类分子复合物，受MＨCⅡ类分子限制的细胞是····（)A、CD4＋T细胞 B、CD８+T细胞 Ｃ、T细胞D、T细胞１3.重要辨认内源性抗原肽－MＨCⅠ类分子复合物，受MＨCⅠ类分子限制的细胞是···（)A、ＣD4+T细胞ﻩﻩB、CＤ８+T细胞ﻩC、T细胞D、T细胞14．关于γδT细胞，描述错误的是··············································(）A、不受MＨC限制ﻩB、受体缺少多样性C、多为CD4—ＣD8—细胞 D、重要分布在外周血15.T细胞在胸腺的发育过程中，表达前T细胞受体的细胞称为····················()A、祖T细胞B、前Ｔ细胞C、双阳性细胞D、单阳性细胞16.T细胞在胸腺的发育过程中，进行TCＲ链基因重排的阶段是···················（）A、祖T细胞B、前Ｔ细胞C、双阳性细胞Ｄ、单阳性细胞17．T细胞在胸腺的发育过程中,进行TCＲ链基因重排的阶段是···················（）Ａ、祖T细胞Ｂ、前Ｔ细胞C、双阳性细胞D、单阳性细胞1８．下列重要辅助B细胞活化，促进Ｂ细胞的增殖、分化和抗体生成的T细胞是·······（)A、Tｈ1B、Tｈ２Ｃ、Ｔh3D、Tr119．被称为TCR的“共受体”的分化抗原是······································(）A、CD２8、CTＬA－4B、CD４、CD８C、CD4０、CD40LD、ＣD2、LＦA２2０．下列T细胞的共刺激分子及其配体,配对错误的是····························()A、CD2８与ＣＤ８0／CD８6B、CＴLA-4与CＤ80/CD86C、CD40与CD40L Ｄ、LＦＡ-1与LFA-221．下列不属于重要介导黏附作用的Ｔ细胞表面分子是···························(）Ａ、CD２B、ICAＭ-1C、LFA-1D、ＣTＬA-４２2．下列不能通过FaｓL/Fas途径诱导靶细胞凋亡的细胞是·························(）A、效应ＣTLB、ＮKC、NＫTＤ、Ｔh223．下列细胞间互相作用无MHC限制性的是····································(）A、Th与B细胞ﻩB、Th与ＤC细胞C、NＫT与靶细胞 ﻩD、CTL与肿瘤细胞２4.活化后能促进T细胞活化信号的转导,与CD4/CＤ８胞浆区相联的PＴＫ是·········()A、p５６LcｋB、p5９FyｎC、ZAＰ-7０D、PＬC-γ２５.T细胞在胸腺的发育过程中，进行TCR链基因重排的阶段是···················(）Ａ、祖T细胞B、前T细胞Ｃ、双阳性细胞D、单阳性细胞2６.T细胞在胸腺的发育过程中,最早表达TCR的阶段是··························（)A、祖T细胞B、前T细胞Ｃ、双阳性细胞D、单阳性细胞27．T细胞在胸腺的发育中,经阳性选择后······································（)Ａ、祖T细胞发育成前Ｔ细胞ﻩﻩﻩB、前T细胞发育为双阳性细胞C、双阳性细胞发育成单阳性细胞 D、单阳性细胞发育为成熟Ｔ细胞２8.T细胞在胸腺的发育中，经阴性选择后······································(）A、祖T细胞发育为前T细胞 B、前T细胞发育为成双阳性细胞C、双阳性细胞发育为单阳性细胞 ﻩD、单阳性细胞发育为成熟T细胞29.阳性选择的意义是·······················································（)Ａ、DP分化为ＳPﻩﻩﻩﻩＢ、获得ＭHC限制性C、清除自身反映性T细胞ﻩＤ、A＋B30.关于阳性选择,下列表述错误的是·········································（）A、发生在胸腺的皮质B、被ＴCR辨认自身抗原肽-自身MＨＣⅠ/Ⅱ分子复合物位于树突状细胞表面C、与自身抗原肽－自身MHCⅠ/Ⅱ分子复合物适当亲和力结合的DＰ才干发育成SPD、阳性选择后的SP具有ＭＨC限制性31．关于阴性选择,下列表述错误的是··········································（)A、发生在胸腺的皮质髓质交界处及髓质区B、被TCR辨认自身抗原肽-自身MＨCⅠ/Ⅱ分子复合物位于树突状细胞表面Ｃ、与自身抗原肽-自身MHCⅠ/Ⅱ分子复合物适当亲和力结合的ＤＰ才干发育成ＳPＤ、经历阴性选择后的Ｔ细胞具有自身耐受性32．关于TＣＲ基因重排，下列表述错误的是·····································(）Ａ、TCR链Ｖ区基因由V、D、J基因片段重排而成B、TCＲ链V区由Ｖ、J基因片段重排而成Ｃ、链基因重排顺序为：D-J连接V-DJ连接Ｄ、链基因重排成功的细胞表面表达ＴＣR33.前Ｔ细胞受体,下列表述错误的是··········································(）A、由TCR链与pT组成ﻩ ﻩB、辨认抗原肽-MＨC分子复合物能力弱Ｃ、表达在前T细胞阶段ﻩﻩﻩD、能克制同源染色体上TCR链基因重排34．关于TＣR共受体,下列表述错误的是·······································()A、CD４与MHCⅡ类分子结合ﻩ B、CD8与MＨCⅠ类分子结合C、共受体分子的胞浆区具有ITAM Ｄ、参与T细胞活化第一信号的转导35.关于ＣD４＋Ｔ细胞,下列表述错误的是·······································(）A、在与AＰC的互相作用中,受MHＣⅡ类分子限制B、其TＣR辨认的抗原肽由8~1０氨基酸残基组成C、活化后,分化为Th1、Th2、Th３等效应细胞Ｄ、占T细胞60%～65%36．关于ＣＤ８+Ｔ细胞，下列表述错误的是·······································（)A、在与靶细胞的互相作用中，受MHCⅠ类分子限制ﻩﻩB、活化后,分化为CTLC、其TCＲ辨认的抗原肽由8~1０氨基酸残基组成 ﻩD、占Ｔ细胞60%～65%３7.诱导Th０分化为Th１的细胞因子是·········································()A、IL１2、ＩFＮ－ ﻩB、ＩＬ４、IL1０、ＴＧF ﻩＣ、IＬ4 D、IL6、ＴGF3８．诱导Ｔh0分化为Th2的细胞因子是·········································(）A、ＩL1２、IFN-ﻩ B、IL4、ＩＬ10、TGF C、ＩL４ ﻩＤ、IＬ6、TＧF39．诱导Ｔｈ0分化为Ｔh3的细胞因子是·········································()A、IL１2、IFＮ-ﻩﻩＢ、IL4、IL10、TGFﻩ C、IL4 ﻩD、IL6、TGＦ４0.诱导Th0分化为Th１7的细胞因子是········································()A、IL12、IＦN- B、IL4、IＬ10、TGF ﻩC、IＬ４ D、IL6、TGF41.Tｈ３重要产生的细胞因子是···············································(）A、ＩＬ2、ＴNF、IFN-ﻩﻩ ﻩﻩﻩＢ、ＩL4、IL5、IL10、IL１３C、IＬ17、IL2１、IL22、IＬ26、ＴNFﻩﻩ D、ＴGＦ42．Th17产生的细胞因子有··················································()A、ＩL2、TNF、IＦN－ ﻩ ﻩﻩ B、IL4、IL5、IL1０、ＩＬ13C、IL１7、ＩL21、IL22、IL26、TNＦﻩ D、TGF43．Ｔh１重要产生的细胞因子重要是···········································()Ａ、IL2、TNF、ＩFＮ- ﻩ ﻩ B、IL４、IL5、IＬ10、IＬ13C、ＩL17、IL21、IL2２、ＩL２6、TNF ﻩ D、TＧF4４.Th2重要产生的细胞因子有···············································（)A、IＬ2、TＮF、IFN－ ﻩﻩ ﻩB、IＬ４、IL5、IL１0、IＬ１３C、ＩL1７、IL21、ＩL22、IＬ26、ＴNＦﻩﻩﻩＤ、ＴGF45．Ｔｆｈ产生的、在B细胞分化为浆细胞产生抗体和Ig类别转换中发挥重要作用的细胞因子是······································································（)Ａ、IL２1 ﻩﻩ B、IＦN- ﻩC、IL17ﻩ D、TGF４６．Th1产生的对Th２具有克制作用的细胞因子是·······························(）Ａ、TNＦ ﻩB、IFN- C、IL４ﻩ ﻩD、ＴGF４7.Tｈ2产生的对Tｈ１具有克制作用的细胞因子是·······························()A、TＮF ﻩﻩB、IＦN－ﻩ C、IL4 D、TGF二、名词解释TCR-CＤ3复合物ﻩﻩ阳性选择ﻩﻩ阴性选择 前T细胞受体三、填