ROCK2-IN-2-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEROCK2-IN-2Cat.No.:HY-103620CASNo.:1995065-79-6分⼦式:C₁₈H₁₂N₆OS分⼦量:360.39作⽤靶点:ROCK作⽤通路:CellCycle/DNADamage;Cytoskeleton;StemCell/Wnt;TGF-beta/Smad储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:100mg/mL(277.48mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.7748mL13.8739mL27.7477mL5mM0.5550mL2.7748mL5.5495mL10mM0.2775mL1.3874mL2.7748mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>90%cornoil1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemESolubility:≥2.5mg/mL(6.94mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性ROCK2-IN-2⼀种选择性ROCK2抑制剂，IC50<1μM。详细信息请参考专利⽂献US20180093978A1中的化合物A-30。IC50&TargetROCK21μM(IC50)体外研究Rho-associatedproteinkinase(ROCK)isamemberoftheserine-threonineproteinkinasefamily.ROCK,whichexistsintwoisoforms,ROCK1andROCK2,isaneffectormoleculeofRhoA,andtheRhoA/ROCKsignalingpathwayisinvolvedinanumberofcellularfunctions,whichinclude,forexample,actinorganization,celladhesion,cellmigration,andcytokinesis.Inaddition,theRhoA/ROCKsignalingpathwayisinvolvedinregulatingsmoothmusclecontraction.InhibitorsofROCKhavebeenreportedtobeusefulfortreatingmultiplemedicaldisorders,suchasfibrosis,inflammatorydisorders,autoimmunedisorders,andcardiovasculardisorders[1].REFERENCES[1].Aicher,ThomasDaniel,etal.INDAZOLYLTHIADIAZOLAMINESANDRELATEDCOMPOUNDSFORINHIBITIONOFRHO-ASSOCIATEDPROTEINKINASEANDTHETREATMENTOFDISEASE.US20180093978A1.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400